Age | Gender | Prostate carcinoma | Disease Organ Localized | Low Risk Very Disease recurrence | Lesion TNM clinical staging | Gleason score | Prostate specific antigen measurement Preoperative | Disease recurrence Percentage Timespan
Item
age 19 years or older. men with prostate cancer, who have organ-localized disease with very low risk of disease recurrence, as indicated by stage pt2, n0, m0 lesions, combined gleason score of 6 or less with no gleason 4 elements, and preoperative psa<10 ng/ml. the rationale for selecting men with these criteria is that this group of men has <0.5% disease recurrence rate over ten years
boolean
C0001779 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
C0600139 (UMLS CUI [3])
C0012634 (UMLS CUI [4,1])
C0178784 (UMLS CUI [4,2])
C0392752 (UMLS CUI [4,3])
C3538919 (UMLS CUI [5,1])
C0442824 (UMLS CUI [5,2])
C0679254 (UMLS CUI [5,3])
C0221198 (UMLS CUI [6,1])
C3258246 (UMLS CUI [6,2])
C3203027 (UMLS CUI [7])
C0201544 (UMLS CUI [8,1])
C0445204 (UMLS CUI [8,2])
C0679254 (UMLS CUI [9,1])
C0439165 (UMLS CUI [9,2])
C0872291 (UMLS CUI [9,3])
PSA Level Stable Undetectable | Prostate specific antigen measurement | Status post Radical prostatectomy
Item
stable and undetectable psa level (psa <0.1 ng/ml using an assay that has a functional sensitivity of 0.1 ng/ml) for at least two years after radical prostatectomy
boolean
C4086720 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C3827727 (UMLS CUI [1,3])
C0201544 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C0194810 (UMLS CUI [3,2])
Testosterone measurement Liquid Chromatography Mass Spectrometry | Free Testosterone Measurement Equilibrium dialysis | Sexual Dysfunction IIEF Questionnaire | Level of Sexual Desire Score | Fatigue FACIT Fatigue Scale | Physical impairment | Difficulty walking Distance Short Physical Performance Battery score | Difficulty with Climbing Several Flights of Stairs Short Physical Performance Battery score
Item
serum testosterone, measured by lc-ms/ms, <300 mg/dl and/or free testosterone by equilibrium dialysis <60 pg/ml. self-reported sexual dysfunction (iief score <25 or sexual desire score <7), fatigue (facit-f score >30), or physical dysfunction (self-reported difficulty in walking a 1/4 mile or climbing two flights of stairs, short physical performance battery score 4 to 9).
boolean
C0523912 (UMLS CUI [1,1])
C0872318 (UMLS CUI [1,2])
C0202228 (UMLS CUI [2,1])
C1553177 (UMLS CUI [2,2])
C0549622 (UMLS CUI [3,1])
C3641331 (UMLS CUI [3,2])
C4084903 (UMLS CUI [4,1])
C0449820 (UMLS CUI [4,2])
C0015672 (UMLS CUI [5,1])
C3272505 (UMLS CUI [5,2])
C0231171 (UMLS CUI [6])
C0311394 (UMLS CUI [7,1])
C0429886 (UMLS CUI [7,2])
C4075289 (UMLS CUI [7,3])
C0332218 (UMLS CUI [8,1])
C3831080 (UMLS CUI [8,2])
C4075289 (UMLS CUI [8,3])
Informed Consent
Item
ability to understand and the willingness to sign a written informed consent document.
boolean
C0021430 (UMLS CUI [1])
Therapeutic radiology procedure Alone | PSA Level Fluctuating
Item
men who have undergone radiation therapy alone will be excluded because defining biochemical recurrence can be difficult in these men due to fluctuating psa levels.
boolean
C1522449 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
C4086720 (UMLS CUI [2,1])
C0231241 (UMLS CUI [2,2])
Antiandrogen therapy
Item
men receiving androgen deprivation therapy
boolean
C0279492 (UMLS CUI [1])
Hemoglobin measurement
Item
hemoglobin <10 g/dl or >16.5 g/dl
boolean
C0518015 (UMLS CUI [1])
Sleep Apnea Severe Untreated
Item
severe untreated sleep apnea
boolean
C0037315 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0332155 (UMLS CUI [1,3])
Heart failure Uncontrolled
Item
uncontrolled heart failure
boolean
C0018801 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Myocardial Infarction | Acute Coronary Syndrome | Revascularization | Cerebrovascular accident
Item
myocardial infarction, acute coronary syndrome, revascularization surgery, or stroke within 3 months
boolean
C0027051 (UMLS CUI [1])
C0948089 (UMLS CUI [2])
C0581603 (UMLS CUI [3])
C0038454 (UMLS CUI [4])
Creatinine measurement, serum | Alanine aminotransferase increased | Aspartate aminotransferase increased
Item
serum creatinine >2.5 mg/dl; alt or ast greater than 3x the institutional upper limit of normal (uln)
boolean
C0201976 (UMLS CUI [1])
C0151905 (UMLS CUI [2])
C0151904 (UMLS CUI [3])
Hemoglobin A1c measurement | Diabetes Mellitus Requirement Insulin regime
Item
hemoglobin a1c >7.5% or diabetes requiring insulin therapy
boolean
C0474680 (UMLS CUI [1])
C0011849 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0557978 (UMLS CUI [2,3])
Body mass index
Item
body mass index (bmi) >40 kg/m2
boolean
C1305855 (UMLS CUI [1])
Mental disorder Major | Schizophrenia | Bipolar Disorder | Depressive disorder Untreated
Item
major psychiatric disorder, such as schizophrenia, bipolar disorder, or untreated depression
boolean
C0004936 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0036341 (UMLS CUI [2])
C0005586 (UMLS CUI [3])
C0011581 (UMLS CUI [4,1])
C0332155 (UMLS CUI [4,2])
Testosterone | DHEA | Estrogens | GnRH Analog | Androgen Antagonists | Spironolactone | Ketoconazole | Recombinant Human Growth Hormone | Megestrol Acetate | Prednisone U/day | Glucocorticoids Dose Equivalent
Item
use of any of the following medications within the past 6 months: testosterone, dhea, estrogens, gnrh analogs, antiandrogens, spironolactone, ketoconazole, rhgh, megestrol acetate, prednisone 20 mg daily or equivalent doses of other glucocorticoids for more than two weeks
boolean
C0039601 (UMLS CUI [1])
C0011185 (UMLS CUI [2])
C0014939 (UMLS CUI [3])
C1518041 (UMLS CUI [4])
C0002842 (UMLS CUI [5])
C0037982 (UMLS CUI [6])
C0022625 (UMLS CUI [7])
C0384570 (UMLS CUI [8])
C0065879 (UMLS CUI [9])
C0032952 (UMLS CUI [10,1])
C0456683 (UMLS CUI [10,2])
C0017710 (UMLS CUI [11,1])
C0178602 (UMLS CUI [11,2])
C0205163 (UMLS CUI [11,3])