Gender | Age
Item
men aged 18 years old or older
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Intermediate Risk Prostate carcinoma TNM clinical staging | Prostate specific antigen measurement | Gleason score | High risk Prostate carcinoma TNM clinical staging
Item
clinical diagnosis of intermediate (one or more of stage t2, or psa >10ng/ml, or gleason score of at least 7) or high risk prostate cancer (one or more of stage t2c, or psa >20ng/ml, or gleason score of at least 8)
boolean
C3640764 (UMLS CUI [1,1])
C0600139 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C0201544 (UMLS CUI [2])
C3203027 (UMLS CUI [3])
C4319571 (UMLS CUI [4,1])
C0600139 (UMLS CUI [4,2])
C3258246 (UMLS CUI [4,3])
Patient Suitable Radical prostatectomy
Item
patient suitable for radical prostatectomy, following discussion at specialist mdt and subsequent review by surgical team
boolean
C0030705 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C0194810 (UMLS CUI [1,3])
Barrier Contraception Willing | Condoms, Male | Spermatocidal Agents
Item
willing to use barrier contraceptive method, e.g. condom & spermicide
boolean
C0004764 (UMLS CUI [1,1])
C0600109 (UMLS CUI [1,2])
C0009653 (UMLS CUI [2])
C0037862 (UMLS CUI [3])
Bone Marrow Mature Neutrophils Present | Organ function
Item
adequate bone marrow reserve or organ function (as specified in the study protocol)
boolean
C0005953 (UMLS CUI [1,1])
C1708947 (UMLS CUI [1,2])
C0678852 (UMLS CUI [2])
Chest radiography Normal | Oxygen saturation within reference range | CT thorax normal
Item
normal chest radiograph and oxygen saturations, or normal ct thorax
boolean
C0039985 (UMLS CUI [1,1])
C0205307 (UMLS CUI [1,2])
C0853673 (UMLS CUI [2])
C1141870 (UMLS CUI [3])
Medical contraindication AZD2014
Item
contraindication to azd2014 (as specified in the study protocol)
boolean
C1301624 (UMLS CUI [1,1])
C2981846 (UMLS CUI [1,2])
Coronary Artery Bypass Surgery | Angioplasty | Vascular stent | Myocardial Infarction | Angina Pectoris | Congestive heart failure New York Heart Association Classification | Ventricular arrhythmia Treatment required for | Supraventricular arrhythmia Uncontrolled | ATRIAL FIBRILLATION UNCONTROLLED | Brain hemorrhage | Thrombotic stroke | Transient Ischemic Attack | Central nervous system haemorrhage
Item
patients who have experienced any of the following procedures in the past 12 months: coronary artery bypass graft; angioplasty; vascular stent; myocardial infarction; angina pectoris; congestive heart failure (new york heart association grade of 2 or above); ventricular arrhythmias requiring continuous therapy; supraventricular arrhythmias including atrial fibrillation, which are uncontrolled; haemorrhagic or thrombotic stroke including transient ischaemic attacks or any other cns bleeding.
boolean
C0010055 (UMLS CUI [1])
C0162577 (UMLS CUI [2])
C0183521 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
C0002962 (UMLS CUI [5])
C0018802 (UMLS CUI [6,1])
C1275491 (UMLS CUI [6,2])
C0085612 (UMLS CUI [7,1])
C0332121 (UMLS CUI [7,2])
C0428974 (UMLS CUI [8,1])
C0205318 (UMLS CUI [8,2])
C0741284 (UMLS CUI [9])
C0553692 (UMLS CUI [10])
C0242129 (UMLS CUI [11])
C0007787 (UMLS CUI [12])
C3267019 (UMLS CUI [13])
Chemotherapy | Biological treatment | Therapeutic radiology procedure | Androgens | Thalidomide | Immunotherapy | Antineoplastic Agents | Investigational New Drugs
Item
previous chemotherapy, biological therapy, radiation therapy, androgens, thalidomide, immunotherapy, other anticancer agents and/or investigational agents within 28 days of starting study treatment.
boolean
C0392920 (UMLS CUI [1])
C1531518 (UMLS CUI [2])
C1522449 (UMLS CUI [3])
C0002844 (UMLS CUI [4])
C0039736 (UMLS CUI [5])
C0021083 (UMLS CUI [6])
C0003392 (UMLS CUI [7])
C0013230 (UMLS CUI [8])
Major surgery | Exception Vascular Access Device Placement | Minor Surgical Procedures
Item
major surgery within 4 weeks prior to study entry (excluding placement of vascular access), or minor surgery within 2 weeks of entry into the study
boolean
C0679637 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1519955 (UMLS CUI [2,2])
C0038904 (UMLS CUI [3])
CYP2C8 Inhibitors Strong | CYP2C8 Inhibitors Moderate | CYP2C8 Inducers Strong | CYP2C8 Inducers Moderate | Gemfibrozil | Trimethoprim | Thiazolidinediones | montelukast | deferasirox | Quercetin
Item
potent or moderate inhibitors and inducers of cyp2c8 if taken within the stated wash-out period: gemfibrozil, trimethoprim, glitazones, montelukast, deferasirox and quercetin (1-week minimum wash out period)
boolean
C3850061 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C3850061 (UMLS CUI [2,1])
C0205081 (UMLS CUI [2,2])
C3850048 (UMLS CUI [3,1])
C0442821 (UMLS CUI [3,2])
C3850048 (UMLS CUI [4,1])
C0205081 (UMLS CUI [4,2])
C0017245 (UMLS CUI [5])
C0041041 (UMLS CUI [6])
C1257987 (UMLS CUI [7])
C0298130 (UMLS CUI [8])
C1619629 (UMLS CUI [9])
C0034392 (UMLS CUI [10])
Hematopoietic Cell Growth Factors | G-CSF | GM-CSF
Item
any haematopoietic growth factors, e.g. g-csf, gm-csf, within 4 weeks prior to receiving study drug
boolean
C0079490 (UMLS CUI [1])
C0079459 (UMLS CUI [2])
C0079460 (UMLS CUI [3])
Systemic disease Severe | Systemic disease Uncontrolled
Item
as judged by the investigator, any evidence of severe or uncontrolled systemic disease (as specified in the study protocol)
boolean
C0442893 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0442893 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Echocardiogram abnormal | MUGA scan abnormal
Item
abnormal echo or muga at baseline
boolean
C0476369 (UMLS CUI [1])
C0853480 (UMLS CUI [2])
Prolonged QTc interval resting mean
Item
mean resting qtc of 470msec or above (as per local reading)
boolean
C1560305 (UMLS CUI [1,1])
C0035253 (UMLS CUI [1,2])
C0444504 (UMLS CUI [1,3])
Pharmaceutical Preparations Causing Prolonged QT interval | Factor At risk Prolonged QT interval | Pharmaceutical Preparations At risk Cardiac Arrhythmia | Torsades de Pointes
Item
concomitant medications known to prolong qt interval, or with factors that increase the risk of qtc prolongation, or risk of arrythmic events (examples specified in study protocol). history of torsades de pointes.
boolean
C0013227 (UMLS CUI [1,1])
C0678227 (UMLS CUI [1,2])
C0151878 (UMLS CUI [1,3])
C1521761 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C0151878 (UMLS CUI [2,3])
C0013227 (UMLS CUI [3,1])
C1444641 (UMLS CUI [3,2])
C0003811 (UMLS CUI [3,3])
C0040479 (UMLS CUI [4])
Diabetes Mellitus, Insulin-Dependent | DIABETES MELLITUS NON INSULIN DEPENDENT UNCONTROLLED
Item
patients with diabetes type i or uncontrolled type ii as judged by the investigator
boolean
C0011854 (UMLS CUI [1])
C0743118 (UMLS CUI [2])
Study Subject Participation Status Inappropriate | Protocol Compliance Unlikely
Item
judgement by the investigator that the patient is unsuitable to participate in the study and the patient is unlikely to comply with study procedures, restrictions and requirements.
boolean
C2348568 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C0750558 (UMLS CUI [2,2])
Informed Consent Unable
Item
unable to provide informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])