Informed Consent
Item
1. willing and able to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Age
Item
2. between the ages of 50-80 years old.
boolean
C0001779 (UMLS CUI [1])
Parkinson Disease
Item
3. male or female with idiopathic pd who fulfill uk pd society brain bank criteria for diagnosis of parkinson's disease.
boolean
C0030567 (UMLS CUI [1])
Parkinson Disease Early stage Unified Parkinson's Disease Rating Scale | Disease length | Dopaminergic Agents Absent
Item
4. early stage subjects will need to have unified parkinson's disease rating scale (updrs) motor scores of < 10, be within 3 years of diagnosis, and not requiring dopaminergic therapy
boolean
C0030567 (UMLS CUI [1,1])
C2363430 (UMLS CUI [1,2])
C3639721 (UMLS CUI [1,3])
C0872146 (UMLS CUI [2])
C0013036 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Parkinson Disease Late stage Unified Parkinson's Disease Rating Scale | Disease length
Item
5. later stage subjects will need to have unified parkinson's disease rating scale motor scores of > 20 and be > 5 years from diagnosis
boolean
C0030567 (UMLS CUI [1,1])
C0544467 (UMLS CUI [1,2])
C3639721 (UMLS CUI [1,3])
C0872146 (UMLS CUI [2])
Gender
Item
6. if female, one of the following three scenarios must apply:
boolean
C0079399 (UMLS CUI [1])
Postmenopausal state
Item
at least two years post-menopausal
boolean
C0232970 (UMLS CUI [1])
Female Sterilization
Item
surgically sterile
boolean
C0015787 (UMLS CUI [1])
Urine pregnancy test negative | Contraceptive methods | Contraceptives, Oral | Intrauterine Devices | Contraceptive implant | Contraception, Barrier | Sexual Abstinence | Breast Feeding To be stopped
Item
negative urine pregnancy test, and following a reliable method of birth control (oral contraceptive, intrauterine device, contraceptive implant, barrier, or abstinence) for at least two months prior to entry, and agreeing both to follow a reliable method of birth control, and (if relevant) to desist from breast feeding during, and for two weeks following tracer administration.
boolean
C0430057 (UMLS CUI [1])
C0700589 (UMLS CUI [2])
C0009905 (UMLS CUI [3])
C0021900 (UMLS CUI [4])
C1657106 (UMLS CUI [5])
C0004764 (UMLS CUI [6])
C0036899 (UMLS CUI [7])
C0006147 (UMLS CUI [8,1])
C1272691 (UMLS CUI [8,2])
Sudden onset Parkinsonian Disorders
Item
1. abrupt onset of parkinsonism
boolean
C1276802 (UMLS CUI [1,1])
C0242422 (UMLS CUI [1,2])
Syndrome Similar Parkinson Disease | Progressive supranuclear palsy | Multiple System Atrophy
Item
2. 'other parkinson-like syndromes (e.g. progressive supranuclear palsy, multiple system atrophy)
boolean
C0039082 (UMLS CUI [1,1])
C2348205 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
C0038868 (UMLS CUI [2])
C0393571 (UMLS CUI [3])
Condition Excludes SPECT
Item
3. any condition that would preclude successful completion of spect scanning
boolean
C0348080 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0040399 (UMLS CUI [1,3])
Anticoagulant therapy
Item
4. use of anti-coagulant therapy
boolean
C0150457 (UMLS CUI [1])
Disorder of eye | Interpretation OCT Data Complicated
Item
5. any clinically significant eye disease that would complicate interpretation of oct data
boolean
C0015397 (UMLS CUI [1])
C0459471 (UMLS CUI [2,1])
C0920367 (UMLS CUI [2,2])
C1511726 (UMLS CUI [2,3])
C0231242 (UMLS CUI [2,4])
Pharmaceutical Preparations Interfere with Tracer SPECT | Cocaine | Amphetamines | Methylphenidate | Ephedrine | Phentermine | Bupropion | Fentanyl | Selective Serotonin Reuptake Inhibitors
Item
6. use of any drugs that would alter or interfere with tracer binding for spect imaging studies (ex., cocaine, amphetamines, methylphenidate, ephedrine, phentermine, bupropion, fentanyl, selective serotonin reuptake inhibitors).
boolean
C0013227 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C1522485 (UMLS CUI [1,3])
C0040399 (UMLS CUI [1,4])
C0009170 (UMLS CUI [2])
C0002667 (UMLS CUI [3])
C0025810 (UMLS CUI [4])
C0014479 (UMLS CUI [5])
C0031447 (UMLS CUI [6])
C0085208 (UMLS CUI [7])
C0015846 (UMLS CUI [8])
C0360105 (UMLS CUI [9])
Hypersensitivity Imaging Agent | Hypersensitivity Lugol's solution | Hypersensitivity Potassium perchlorate
Item
7. known sensitivity to the imaging agent or to lugol's solution or to potassium perchlorate.
boolean
C0020517 (UMLS CUI [1,1])
C1512628 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0065234 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0071774 (UMLS CUI [3,2])
Kidney Disease Severe
Item
8. history or presence of severe renal disease.
boolean
C0022658 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])