Age
Item
age > 18 years.
boolean
C0001779 (UMLS CUI [1])
Ability Clinical Trial Visit
Item
ability to attend a 3 hour study visit in seattle, wa.
boolean
C0085732 (UMLS CUI [1,1])
C0008976 (UMLS CUI [1,2])
C0008952 (UMLS CUI [1,3])
Able to read English Language | Able to speak English Language
Item
ability to read and speak english.
boolean
C0586740 (UMLS CUI [1,1])
C0376245 (UMLS CUI [1,2])
C0564215 (UMLS CUI [2,1])
C0376245 (UMLS CUI [2,2])
Diagnostic criteria Quantity Parkinson Disease
Item
have three or more of the required positive criteria for pd from step 3 of the uk brain bank diagnostic criteria for parkinson's disease.
boolean
C0679228 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
Modified Hoehn and Yahr Staging | Bilateral Disease | Disability severe Absent
Item
a modified hoehn & yahr stage 2-3. (bilateral disease, not severely disabled.)
boolean
C3639878 (UMLS CUI [1])
C1511113 (UMLS CUI [2])
C0424990 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Medical contraindication Magnetic Resonance Imaging | Artificial cardiac pacemaker | Pacemaker Wire | Aneurysm clip | Implants Electronic | Increased body weight | Metal Soft tissue | Metal foreign body in eye region | Ocular Prosthesis | Claustrophobia | Substance Use Disorders | Use of Recreational Drugs | Pregnancy | Medical contraindication Additional
Item
any contra-indication to magnetic resonance imaging, including pacemaker, pacemaker wires, aneurysm clip, or any electronic implant, weight over 136 kg (300 lb), metal embedded in soft tissue or in the eye, prosthetic eye, claustrophobia, substance abuse, use of recreational drugs, pregnancy, or other medical contraindications.
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0030163 (UMLS CUI [2])
C0030163 (UMLS CUI [3,1])
C4522306 (UMLS CUI [3,2])
C0179977 (UMLS CUI [4])
C0021102 (UMLS CUI [5,1])
C0013850 (UMLS CUI [5,2])
C0043094 (UMLS CUI [6])
C0025552 (UMLS CUI [7,1])
C0225317 (UMLS CUI [7,2])
C0562528 (UMLS CUI [8])
C0015417 (UMLS CUI [9])
C0008909 (UMLS CUI [10])
C0038586 (UMLS CUI [11])
C1524063 (UMLS CUI [12,1])
C0242508 (UMLS CUI [12,2])
C0032961 (UMLS CUI [13])
C1301624 (UMLS CUI [14,1])
C1524062 (UMLS CUI [14,2])
Epilepsy | Cerebrovascular accident | Operation on brain | Brain Disease structural
Item
a history of epilepsy, stroke, brain surgery, or structural brain disease.
boolean
C0014544 (UMLS CUI [1])
C0038454 (UMLS CUI [2])
C0195775 (UMLS CUI [3])
C0006111 (UMLS CUI [4,1])
C0678594 (UMLS CUI [4,2])
Comorbidity Serious | Cancer treatment
Item
the presence of other serious illnesses (discretion of study clinician, e.g. concurrent cancer treatment.)
boolean
C0009488 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0920425 (UMLS CUI [2])
Pregnancy
Item
pregnant.
boolean
C0032961 (UMLS CUI [1])
Sulfur allergy | Allergic Reaction Acetylcysteine | Allergic Reaction MSM | Allergic Reaction SAMe
Item
a history of sulfur sensitivity, e.g. reaction n-acetylcysteine, msm, same.
boolean
C0571095 (UMLS CUI [1])
C1527304 (UMLS CUI [2,1])
C0001047 (UMLS CUI [2,2])
C1527304 (UMLS CUI [3,1])
C0058231 (UMLS CUI [3,2])
C1527304 (UMLS CUI [4,1])
C0036002 (UMLS CUI [4,2])
Asthma
Item
a recent history of asthma.
boolean
C0004096 (UMLS CUI [1])
Glutathione Supplementation Oral | Glutathione Supplementation Intravenous | Glutathione Supplementation intranasal | Glutathione Supplementation nebulized | Glutathione Precursor | Acetylcysteine
Item
supplementation with glutathione (oral, intravenous, intranasal, or nebulized) or the glutathione precursor, n-acetylcysteine, for six months prior to baseline study visit.
boolean
C0017817 (UMLS CUI [1,1])
C0242297 (UMLS CUI [1,2])
C1527415 (UMLS CUI [1,3])
C0017817 (UMLS CUI [2,1])
C0242297 (UMLS CUI [2,2])
C1522726 (UMLS CUI [2,3])
C0017817 (UMLS CUI [3,1])
C0242297 (UMLS CUI [3,2])
C1522019 (UMLS CUI [3,3])
C0017817 (UMLS CUI [4,1])
C0242297 (UMLS CUI [4,2])
C1549541 (UMLS CUI [4,3])
C0017817 (UMLS CUI [5,1])
C1709634 (UMLS CUI [5,2])
C0001047 (UMLS CUI [6])
Hypersensitivity Pharmaceutical Preparations Containing Sulfur | Hypersensitivity Supplements Containing Sulfur | Acetylcysteine allergy | Hypersensitivity Methylsulfonylmethane
Item
history of sensitivity to sulfur containing medications/ supplements, i.e. nac, msm.
boolean
C0020517 (UMLS CUI [1,1])
C0013227 (UMLS CUI [1,2])
C0332256 (UMLS CUI [1,3])
C0038774 (UMLS CUI [1,4])
C0020517 (UMLS CUI [2,1])
C0242295 (UMLS CUI [2,2])
C0332256 (UMLS CUI [2,3])
C0038774 (UMLS CUI [2,4])
C0571014 (UMLS CUI [3])
C0020517 (UMLS CUI [4,1])
C0058231 (UMLS CUI [4,2])
Substance Use Disorders | Substance Dependence
Item
current drug or alcohol use or dependence.
boolean
C0038586 (UMLS CUI [1])
C0038580 (UMLS CUI [2])
Informed Consent Unable | Informed Consent Unwilling | Dementia | Confusion
Item
inability/unwillingness to provide informed consent. (e.g. diagnosis of dementia, confusion about study goals or participation.)
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
C0497327 (UMLS CUI [3])
C0009676 (UMLS CUI [4])
Communicable Disease | Upper Respiratory Infection | Skin Infection
Item
acute infection (e.g. upper respiratory, dermal) in the previous 30 days.
boolean
C0009450 (UMLS CUI [1])
C0041912 (UMLS CUI [2])
C0037278 (UMLS CUI [3])
Mental disorders
Item
diagnosis of any mental illness, ever. (mental illness has been associated with glutathione depletion.)
boolean
C0004936 (UMLS CUI [1])
Chronic disease | Hepatitis C | Autoimmune Diseases
Item
diagnosis of any chronic disease, ever. (e.g. hep c, autoimmune disease, etc.)
boolean
C0008679 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C0004364 (UMLS CUI [3])
Head tremor | Head Dyskinesia | Control Unsuccessful
Item
head tremor or head dyskinesia that cannot be comfortably controlled for 90 minutes.
boolean
C0239882 (UMLS CUI [1])
C0018670 (UMLS CUI [2,1])
C0013384 (UMLS CUI [2,2])
C0243148 (UMLS CUI [3,1])
C1272705 (UMLS CUI [3,2])