Age | Parkinson Disease Hoehn and Yahr grades | Parkinson Disease Dopa Responsive
Item
men and women aged 30 to 80 years with dopa-responsive pd hoehn and yahr (hy) grade of 2 to 4 while "off"
boolean
C0001779 (UMLS CUI [1])
C0030567 (UMLS CUI [2,1])
C0451215 (UMLS CUI [2,2])
C0030567 (UMLS CUI [3,1])
C0013023 (UMLS CUI [3,2])
C0205342 (UMLS CUI [3,3])
Therapeutic procedure | Levodopa
Item
must be on a regimen including levodopa
boolean
C0087111 (UMLS CUI [1])
C0023570 (UMLS CUI [2])
Levodopa Cumulative Dose per day | Dopamine Agonists Cumulative Dose per day
Item
total dose of levodopa and dopamine agonists (using dopamine equivalents) has to be equal to or more than 300 milligrams per day
boolean
C0023570 (UMLS CUI [1,1])
C2986497 (UMLS CUI [1,2])
C0439505 (UMLS CUI [1,3])
C0178601 (UMLS CUI [2,1])
C2986497 (UMLS CUI [2,2])
C0439505 (UMLS CUI [2,3])
Gait abnormality | Freezing of gait MDS-UPDRS
Item
gait difficulties with freezing of gait as defined by mds-updrs i score ≥ 2 in fog
boolean
C0575081 (UMLS CUI [1])
C0860515 (UMLS CUI [2,1])
C3639714 (UMLS CUI [2,2])
Pharmaceutical Preparations Optimal Parkinson Disease
Item
optimal conventional pd medication for > 1 month prior to screening
boolean
C0013227 (UMLS CUI [1,1])
C2698651 (UMLS CUI [1,2])
C0030567 (UMLS CUI [1,3])
Rehabilitation therapy Scheduled Freezing of gait
Item
scheduled for rehabilitative intervention for the treatment of freezing of gait
boolean
C0034991 (UMLS CUI [1,1])
C0205539 (UMLS CUI [1,2])
C0860515 (UMLS CUI [1,3])
Comorbidity | Mental disorders
Item
significant concurrent medical or psychiatric disease
boolean
C0009488 (UMLS CUI [1])
C0004936 (UMLS CUI [2])
Seizures | Epilepsy
Item
history of seizures and epilepsy
boolean
C0036572 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
Dementia | Neurodegenerative Disorders | In addition to Parkinson Disease
Item
dementia or other neurodegenerative disease (besides pd)
boolean
C0497327 (UMLS CUI [1])
C0524851 (UMLS CUI [2])
C0332287 (UMLS CUI [3,1])
C0030567 (UMLS CUI [3,2])
Pallidotomy | Electrodes, Implanted | Deep brain stimulation generator
Item
pallidotomy, implanted electrodes and generator for deep brain stimulation
boolean
C0195893 (UMLS CUI [1])
C0013814 (UMLS CUI [2])
C4075668 (UMLS CUI [3])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])
Foreign Bodies Implanted | Pump Implanted | Hearing Aids Implanted | Metal plate Skull | Plates, Cranioplasty | Ophthalmological implant Metallic
Item
surgically or traumatically implanted foreign bodies such as an implanted medical pump, implanted hearing aids, metal plate in the skull, or metal implant in the skull or eyes (other than dental appliances or fillings) that may pose a physical hazard during tdcs.
boolean
C0016542 (UMLS CUI [1,1])
C0021102 (UMLS CUI [1,2])
C0182537 (UMLS CUI [2,1])
C0021102 (UMLS CUI [2,2])
C0018768 (UMLS CUI [3,1])
C0021102 (UMLS CUI [3,2])
C0013866 (UMLS CUI [4,1])
C2951888 (UMLS CUI [4,2])
C0182313 (UMLS CUI [5])
C0581278 (UMLS CUI [6,1])
C2986473 (UMLS CUI [6,2])
Study Subject Participation Status At risk | Tendency to fall | Fatigue Excessive | Frailty General | Apprehensiveness Excessive
Item
study would cause undue risk or stress for reasons such as tendency to fall, excessive fatigue, general frailty, or excessive apprehensiveness.
boolean
C2348568 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C2830327 (UMLS CUI [2])
C0015672 (UMLS CUI [3,1])
C0442802 (UMLS CUI [3,2])
C0424594 (UMLS CUI [4,1])
C0205246 (UMLS CUI [4,2])
C0233485 (UMLS CUI [5,1])
C0442802 (UMLS CUI [5,2])
Postural instability | Falls Daily | Lacking Able to walk Distance
Item
significant postural instability with daily falls, inability to walk the parcours or inability to walk 10 meters.
boolean
C1843921 (UMLS CUI [1])
C0085639 (UMLS CUI [2,1])
C0332173 (UMLS CUI [2,2])
C0332268 (UMLS CUI [3,1])
C2712089 (UMLS CUI [3,2])
C0429886 (UMLS CUI [3,3])
Impaired cognition MoCA questionnaire total score | Mental impairment | Informed Consent Unable
Item
presence of significant cognitive dysfunction as determined by montreal cognitive assessment (moca) <20 or mentally impaired patients having no capacity to provide their own consent (the physician establishing the diagnosis and applying updrs will evaluate patient's mental capacity using conventional clinical interview).
boolean
C0338656 (UMLS CUI [1,1])
C3836787 (UMLS CUI [1,2])
C0683322 (UMLS CUI [2])
C0021430 (UMLS CUI [3,1])
C1299582 (UMLS CUI [3,2])
Comorbidity Contributing Gait Dysfunction | Musculoskeletal Disease | Rheumatic disorder | Heart Disease
Item
presence of other co-morbid conditions that can contribute to gait dysfunction (orthopedic, rheumatologic, cardiac, other)
boolean
C0009488 (UMLS CUI [1,1])
C1880177 (UMLS CUI [1,2])
C0751830 (UMLS CUI [1,3])
C0026857 (UMLS CUI [2])
C3495832 (UMLS CUI [3])
C0018799 (UMLS CUI [4])
Hallucinations
Item
presence of clinically significant hallucinations
boolean
C0018524 (UMLS CUI [1])
Rehabilitation therapy Freezing of gait
Item
participation in any rehabilitation therapy for fog within the last six months prior to screening
boolean
C0034991 (UMLS CUI [1,1])
C0860515 (UMLS CUI [1,2])