Non-Small Cell Lung Carcinoma
Item
1. histologically or cytologically confirmed nsclc
boolean
C0007131 (UMLS CUI [1])
EGFR gene mutation Negative | EGFR gene mutation Status Unknown | ALK gene mutation Negative | ALK gene mutation Status Unknown | ROS1 Gene Mutation Negative | ROS1 Gene Mutation Status Unknown
Item
2. negative or unknown egfr, alk, ros1 mutation status (testing not mandatory)
boolean
C3266992 (UMLS CUI [1,1])
C1513916 (UMLS CUI [1,2])
C3266992 (UMLS CUI [2,1])
C0449438 (UMLS CUI [2,2])
C0439673 (UMLS CUI [2,3])
C2825843 (UMLS CUI [3,1])
C1513916 (UMLS CUI [3,2])
C2825843 (UMLS CUI [4,1])
C0449438 (UMLS CUI [4,2])
C0439673 (UMLS CUI [4,3])
C4331213 (UMLS CUI [5,1])
C1513916 (UMLS CUI [5,2])
C4331213 (UMLS CUI [6,1])
C0449438 (UMLS CUI [6,2])
C0439673 (UMLS CUI [6,3])
Patient Staged FDG-PET/CT of the Whole Body | Patient Staged MRI brain
Item
3. patient has been staged with fdg pet-ct whole body scan and brain mri. scans to be performed within 42 days of registration.
boolean
C0030705 (UMLS CUI [1,1])
C3846398 (UMLS CUI [1,2])
C4527276 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C3846398 (UMLS CUI [2,2])
C0412675 (UMLS CUI [2,3])
Chemotherapy cycle Quantity | Chemotherapy Platinum-Based Double | Cisplatin | Carboplatin
Item
4. patient is fit to receive at least four cycles of platinum-based doublet chemotherapy, cisplatin or carboplatin, according to local guidelines and assessment
boolean
C1302181 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0392920 (UMLS CUI [2,1])
C1514162 (UMLS CUI [2,2])
C0205173 (UMLS CUI [2,3])
C0008838 (UMLS CUI [3])
C0079083 (UMLS CUI [4])
Primary tumor Amenable Therapeutic radiology procedure Radical | Radiotherapy fractionation conventional | Radiotherapy, Stereotactic | Lymph node involvement | Radiation Field conventional | Secondary malignant neoplasm of lymph node
Item
5. primary tumour amenable to radical rt (either conventional fractionation or srt) i) nodes included in the radical rt volume will not count towards the number of sites of metastases ii) conventional rt fields do not need to be contiguous. iii) nodes not treated in the radical rt volume are counted as metastases. the same rt dose constraint eligibility criteria will apply to these nodes as to other metastases.
boolean
C0677930 (UMLS CUI [1,1])
C3900053 (UMLS CUI [1,2])
C1522449 (UMLS CUI [1,3])
C0439807 (UMLS CUI [1,4])
C3161031 (UMLS CUI [2,1])
C0439858 (UMLS CUI [2,2])
C3846112 (UMLS CUI [3])
C0806692 (UMLS CUI [4])
C1882536 (UMLS CUI [5,1])
C0439858 (UMLS CUI [5,2])
C0686619 (UMLS CUI [6])
Cervical lymph nodes TNM clinical staging
Item
iv) considering neck nodes, only station 1 nodes (foundation system) are considered n3. higher neck nodes are considered as metastases.
boolean
C0588054 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Pulmonary function
Item
6. acceptable lung function in accordance with local guidelines
boolean
C0231921 (UMLS CUI [1])
Neoplasm Metastasis Site Quantity | Lymph Node Involvement | Disease Extracranial Site Quantity
Item
7. between one and three sites of metastatic disease i) each individual involved lymph node outside of the radical rt volume will count as 1 site, even within the same nodal region ii) this must include at least one site of extra-cranial disease.
boolean
C0027627 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0806692 (UMLS CUI [2])
C0012634 (UMLS CUI [3,1])
C0580586 (UMLS CUI [3,2])
C1515974 (UMLS CUI [3,3])
C1265611 (UMLS CUI [3,4])
Neoplasm Metastasis | Sites suitable Stereotactic Radiotherapy
Item
8. all sites of metastatic disease suitable for srt
boolean
C0027627 (UMLS CUI [1])
C1515974 (UMLS CUI [2,1])
C3900053 (UMLS CUI [2,2])
C3846112 (UMLS CUI [2,3])
Comorbidity Absent | Pulmonary Fibrosis Absent | Connective Tissue Diseases Absent
Item
9. no relevant co-morbidities, including pulmonary fibrosis, connective tissue disorders.
boolean
C0009488 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0034069 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0009782 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
ECOG performance status
Item
10. ecog performance status 0 to 1 at time of registration
boolean
C1520224 (UMLS CUI [1])
Secondary malignant neoplasm of bone | Stabilization Before Stereotactic Radiotherapy
Item
11. for bone metastases, pre-srt stabilisation should be considered as clinically appropriate.
boolean
C0153690 (UMLS CUI [1])
C1293130 (UMLS CUI [2,1])
C0332152 (UMLS CUI [2,2])
C3846112 (UMLS CUI [2,3])
Neoplasm Metastasis Quantity
Item
12. patients with up to 3 metastases at the time of registration but less than 3 are visible after systemic therapy are still eligible for randomisation.
boolean
C0027627 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Palliative course of radiotherapy Tumor site
Item
1. patient requires palliative radiotherapy to any tumour site before the start of chemotherapy
boolean
C0475092 (UMLS CUI [1,1])
C0475445 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain MRI brain | Disease Extracranial Absent
Item
2. patients who present with brain metastasis only and no other sites of extra cranial disease, as evidenced by a mri of the brain no more than 42 days prior to registration
boolean
C0220650 (UMLS CUI [1,1])
C0412675 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0580586 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Neoplasm Metastasis Site | Site Free of Constraint Normal
Item
3. metastasis in sites where normal constraints cannot be met.
boolean
C0027627 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C1515974 (UMLS CUI [2,1])
C0332296 (UMLS CUI [2,2])
C0443288 (UMLS CUI [2,3])
C0205307 (UMLS CUI [2,4])
Neoplasm Metastasis Body Region Prior radiation therapy
Item
4. metastasis in a previously irradiated area
boolean
C0027627 (UMLS CUI [1,1])
C0005898 (UMLS CUI [1,2])
C0279134 (UMLS CUI [1,3])
Disease Site Quantity | Status pre- Systemic therapy
Item
5. patients who had more than three sites of disease prior to systemic therapy even if some are no longer visible or have been ablated surgically or by other means.
boolean
C0012634 (UMLS CUI [1,1])
C1515974 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0332152 (UMLS CUI [2,1])
C1515119 (UMLS CUI [2,2])
Primary tumor Involving Blood Vessels Major | Neoplasm Metastasis Involving Blood Vessels Major
Item
6. primary tumour or metastases causing involvement of major blood vessels
boolean
C0677930 (UMLS CUI [1,1])
C1314939 (UMLS CUI [1,2])
C0005847 (UMLS CUI [1,3])
C0205164 (UMLS CUI [1,4])
C0027627 (UMLS CUI [2,1])
C1314939 (UMLS CUI [2,2])
C0005847 (UMLS CUI [2,3])
C0205164 (UMLS CUI [2,4])
Pleural Effusion, Malignant | Malignant pericardial effusion
Item
7. malignant pleural or pericardial effusion
boolean
C0080032 (UMLS CUI [1])
C0220655 (UMLS CUI [2])
Metastases to adrenals Bilateral
Item
8. patients with bilateral adrenal metastases
boolean
C0854178 (UMLS CUI [1,1])
C0238767 (UMLS CUI [1,2])
Ablation therapy Neoplasm Metastasis Quantity | Radiofrequency ablation | Operative Surgical Procedures
Item
9. one or more metastases treated with alternative ablative treatment, e.g. rfa or surgery
boolean
C0547070 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0850292 (UMLS CUI [2])
C0543467 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
10. women who are pregnant or lactating
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])