Non-Small Cell Lung Carcinoma unresectable TNM clinical staging | EGFR Exon 19 Mutation | EGFR Exon 21 Mutation
Item
1. unresectable stage iiia / iiib non-small cell lung cancer with egfr 19/21 mutation.
boolean
C0007131 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
C4289656 (UMLS CUI [2])
C4289654 (UMLS CUI [3])
Cancer treatment Systemic Absent
Item
2. no previous systemic anticancer therapy.
boolean
C0920425 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Life Expectancy
Item
3. life expectancy more than three months.
boolean
C0023671 (UMLS CUI [1])
ECOG performance status
Item
4. ecog performance status of 0 to 1.
boolean
C1520224 (UMLS CUI [1])
Measurable lesion | Prior radiation therapy Absent Measurable lesion Quantity | Exception Disease Progression
Item
5. measurable lesion according to recist with at least one measurable lesion not previously irradiated, unless disease progression has been documented at that site.
boolean
C1513041 (UMLS CUI [1])
C0279134 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1513041 (UMLS CUI [2,3])
C1265611 (UMLS CUI [2,4])
C1705847 (UMLS CUI [3,1])
C0242656 (UMLS CUI [3,2])
Informed Consent
Item
6. patients will be required to provide informed consent before enrollment.
boolean
C0021430 (UMLS CUI [1])
Neoplasm Metastasis Intrapulmonary | Atelectasis Entire hemithorax | Dissemination Pleural | Neoplasm Metastasis Hilar lymph node Contralateral
Item
1. intrapulmonary metastasis, atelectasis of an entire hemithorax,pleural dissemination, or contralateral hilar lymph node metastasis.
boolean
C0027627 (UMLS CUI [1,1])
C0442121 (UMLS CUI [1,2])
C0004144 (UMLS CUI [2,1])
C1269692 (UMLS CUI [2,2])
C0205221 (UMLS CUI [3,1])
C1522720 (UMLS CUI [3,2])
C0027627 (UMLS CUI [4,1])
C1305372 (UMLS CUI [4,2])
C0441988 (UMLS CUI [4,3])
Prior Chemotherapy Non-Small Cell Lung Carcinoma | Radiotherapy to thorax | Targeted Therapy EGFR signaling pathway
Item
2. prior chemotherapy for nsclc, chest irradiation therapy, or therapy directed at the epidermal growth factor receptor pathway.
boolean
C1514457 (UMLS CUI [1,1])
C0007131 (UMLS CUI [1,2])
C4038705 (UMLS CUI [2])
C2985566 (UMLS CUI [3,1])
C1155379 (UMLS CUI [3,2])
Heart Disease Severe | Diabetic - poor control | Communicable Diseases
Item
3. severe heart disease, uncontrolled diabetes mellitus, or active infection.
boolean
C0018799 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0421258 (UMLS CUI [2])
C0009450 (UMLS CUI [3])
Second Primary Cancer | Pregnancy | Breast Feeding
Item
4. active concomitant malignancy, and pregnancy or breast-feeding.
boolean
C0751623 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])