Non-Small Cell Lung Carcinoma | Core biopsy Required
Item
histologically proven non-small-cell lung cancer (core biopsy required).
boolean
C0007131 (UMLS CUI [1])
C1318309 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
Squamous non-small cell lung cancer | Non-squamous non-small cell lung cancer
Item
squamous or non-squamous histology (note - at least 4 squamous patients will be included in the total enrollment of 16 patients)
boolean
C4509816 (UMLS CUI [1])
C4324656 (UMLS CUI [2])
Specimen obtained by core needle biopsy Reviewed By Pathologist
Item
diagnostic core biopsy specimens must be reviewed by a faculty pathologist at skccc or mskcc
boolean
C1960700 (UMLS CUI [1,1])
C1709941 (UMLS CUI [1,2])
C0334866 (UMLS CUI [1,3])
Formalin-fixed paraffin-embedded tissue specimen | Tumor tissue sample Micron Tissue section Quantity | Biomarker Evaluation
Item
either a formalin fixed paraffin block or a minimum of ten 5-micron tissue sections (slides) of tumor biopsy sample must be available for biomarker evaluation (study pathologist must review for adequacy of sampling). this can be obtained from archived tissues, or from a new biopsy if needed.
boolean
C2711483 (UMLS CUI [1])
C0475358 (UMLS CUI [2,1])
C0439201 (UMLS CUI [2,2])
C2316368 (UMLS CUI [2,3])
C1265611 (UMLS CUI [2,4])
C0005516 (UMLS CUI [3,1])
C1261322 (UMLS CUI [3,2])
Non-Small Cell Lung Carcinoma High risk | Excision Option | Disease TNM clinical staging
Item
stage - high risk nsclc with resection option for potential cure, as assessed by a faculty surgeon at skccc or mskcc. this includes clinical stage ib (primary tumor must measure
boolean
C0007131 (UMLS CUI [1,1])
C4319571 (UMLS CUI [1,2])
C0728940 (UMLS CUI [2,1])
C1518601 (UMLS CUI [2,2])
C0012634 (UMLS CUI [3,1])
C3258246 (UMLS CUI [3,2])
Primary tumor Diameter CT scan | Disease TNM clinical staging
Item
≥4cm in diameter on ct imaging), ii and iiia (n1 disease only) (see appendix a):
boolean
C0677930 (UMLS CUI [1,1])
C1301886 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
C0012634 (UMLS CUI [2,1])
C3258246 (UMLS CUI [2,2])
Disease TNM clinical staging
Item
t1a, t1b, t2a, n1, m0
boolean
C0012634 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Disease TNM clinical staging | Diameter size
Item
t2a (≥4cm diameter), n0, m0
boolean
C0012634 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C1301886 (UMLS CUI [2,1])
C0456389 (UMLS CUI [2,2])
Disease TNM clinical staging
Item
t2b, n0 or 1, m0
boolean
C0012634 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Disease TNM clinical staging
Item
t3, n0, m0
boolean
C0012634 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Disease TNM clinical staging | Appropriateness Excision Primary
Item
t3, n1 (deemed suitable for primary resection by treating surgeon)
boolean
C0012634 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C0814634 (UMLS CUI [2,1])
C0728940 (UMLS CUI [2,2])
C0205225 (UMLS CUI [2,3])
ECOG performance status
Item
ecog performance status 0-1
boolean
C1520224 (UMLS CUI [1])
Laboratory Results Stable
Item
stable lab values
boolean
C1254595 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Cardiac function | Prolonged PR interval Absent ECG | Atrioventricular Block Absent ECG
Item
adequate cardiac function as defined by: no evidence of pr prolongation or av block on baseline electrocardiogram (ecg).
boolean
C0232164 (UMLS CUI [1])
C0600125 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1623258 (UMLS CUI [2,3])
C0004245 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C1623258 (UMLS CUI [3,3])
Autoimmune Disease Requirement Systemic steroids | Autoimmune Disease Requirement Immunosuppressive Agents | Inflammatory Bowel Disease | Exception Vitiligo | Exception Childhood asthma resolved | Exception Atopy resolved
Item
any active or history of autoimmune disease (including any history of inflammatory bowel disease), or history of syndrome that required systemic steroids or immunosuppressive medications, except for subjects with vitiligo or resolved childhood asthma/atopy.
boolean
C0004364 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C2825233 (UMLS CUI [1,3])
C0004364 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0021081 (UMLS CUI [2,3])
C0021390 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0042900 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0264408 (UMLS CUI [5,2])
C1514893 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0392707 (UMLS CUI [6,2])
C1514893 (UMLS CUI [6,3])
CORTICOSTEROIDS FOR SYSTEMIC USE | Inhaled steroids allowed
Item
ongoing requirement for systemic corticosteroids. however, inhalational steroids are allowed.
boolean
C3653708 (UMLS CUI [1])
C2065041 (UMLS CUI [2,1])
C0683607 (UMLS CUI [2,2])
Pneumonectomy | Excision Curative Primary tumor
Item
subjects who require or may require pneumonectomy, as assessed by their surgeon, to obtain potentially curative resection of primary tumor.
boolean
C0032284 (UMLS CUI [1])
C0728940 (UMLS CUI [2,1])
C1276305 (UMLS CUI [2,2])
C0677930 (UMLS CUI [2,3])
Metastatic malignant neoplasm to brain | Imaging of brain Required | MRI brain | CT scan of brain Contrast Media
Item
subjects with brain metastasis are excluded from this study and all patients should have brain imaging (either mri brain or ct brain with contrast) prior to enrollment.
boolean
C0220650 (UMLS CUI [1])
C0203860 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0412675 (UMLS CUI [3])
C0412585 (UMLS CUI [4,1])
C0009924 (UMLS CUI [4,2])