Age
Item
Patient age between 18 and 55 years
boolean
C0001779 (UMLS CUI [1])
Diagnosis of RRMS according to McDonald criteria and brain MRI lesion
Item
must have a confirmed diagnosis of relapsing-remitting multiple sclerosis (RRMS) according to McDonald criteria #1-4 (Polman et al., 2005 [appendix I]), and have a prior brain magnetic resonance imaging (MRI) demonstrating lesion(s) consistent with multiple sclerosis (MS) from any point in time.
boolean
C0679228 (UMLS CUI [1,1])
C0751967 (UMLS CUI [1,2])
C0412675 (UMLS CUI [2,1])
C0221198 (UMLS CUI [2,2])
C0332290 (UMLS CUI [2,3])
C0026769 (UMLS CUI [2,4])
EDSS
Item
must have an expanded disability status scale (EDSS) between 0.0 and 5.0, inclusive.
boolean
C0451246 (UMLS CUI [1])
Same dose of IFNβ or GA prior to and during study
Item
Must be taking the same dose of a prescribed IFNβ (either Avonex, Betaseron, Rebif) or GA for at least 12 months consecutively at the time of enrollment and remain on this treatment for the duration of the study
boolean
C0289884 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0332185 (UMLS CUI [1,4])
C0289884 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
C0489652 (UMLS CUI [2,4])
C0015980 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0205360 (UMLS CUI [3,3])
C0332185 (UMLS CUI [3,4])
C0015980 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
C0205360 (UMLS CUI [4,3])
C0489652 (UMLS CUI [4,4])
Primary progressive, secondary progressive, or progressive relapsing MS
Item
primary progressive, secondary progressive, or progressive relapsing MS (as defined by Polman et al. 2005)
boolean
C0751964 (UMLS CUI [1])
C0751965 (UMLS CUI [2])
C0393666 (UMLS CUI [3])
other chronic disease of the immune system, malignancies, acute urologic, or pulmonary disease
Item
other chronic disease of the immune system, malignancies, acute urologic, or pulmonary disease.
boolean
C0205394 (UMLS CUI [1,1])
C0008679 (UMLS CUI [1,2])
C0021053 (UMLS CUI [1,3])
C0006826 (UMLS CUI [2])
C0001314 (UMLS CUI [3,1])
C0042075 (UMLS CUI [3,2])
C0001314 (UMLS CUI [4,1])
C0024115 (UMLS CUI [4,2])
Pregnant or nursing
Item
pregnant or nursing women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Other drug, biologic, or device study participation within 6 months prior
Item
participation within 6 months prior to study enrollment in any other drug, biologic, or device study.
boolean
C0332185 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0013227 (UMLS CUI [1,3])
C0332185 (UMLS CUI [2,1])
C2348568 (UMLS CUI [2,2])
C0005527 (UMLS CUI [2,3])
C0332185 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C0699733 (UMLS CUI [3,3])