Age
Item
age between 18 and 55, inclusive
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
able to give informed consent
boolean
C0021430 (UMLS CUI [1])
Multiple Sclerosis
Item
diagnosis of multiple sclerosis according to revised mcdonald criteria (polman, reingold et al. 2011)
boolean
C0026769 (UMLS CUI [1])
MRI brain Tesla Quantity | Multiple Sclerosis Lesion Quantity | Other Coding
Item
a 7 tesla brain mri demonstrating at least one ms lesion with evidence of a paramagnetic rim
boolean
C0412675 (UMLS CUI [1,1])
C1551055 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0026769 (UMLS CUI [2,1])
C0221198 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C3846158 (UMLS CUI [3])
Exclusion Criteria General
Item
general exclusion criteria:
boolean
C0680251 (UMLS CUI [1,1])
C0205246 (UMLS CUI [1,2])
Liver Dysfunction | Abnormal renal function | Aspartate aminotransferase abnormal | Alanine aminotransferase abnormal | Bilirubin abnormal | Alkaline phosphatase abnormal | Serum creatinine abnormal | Estimated Glomerular Filtration Rate Abnormal
Item
screening labs demonstrating any value for hepatic or renal function levels out of the range of normal, to include ast, alt, bilirubin, alkaline phosphatase, creatinine, egfr
boolean
C0086565 (UMLS CUI [1])
C0151746 (UMLS CUI [2])
C0855623 (UMLS CUI [3])
C0855619 (UMLS CUI [4])
C1142335 (UMLS CUI [5])
C0740888 (UMLS CUI [6])
C0438243 (UMLS CUI [7])
C3811844 (UMLS CUI [8,1])
C0205161 (UMLS CUI [8,2])
Polycythemia Vera | Hemoglobin increased
Item
evidence of polycythemia vera with hemoglobin levels more than 1 standard deviation above the nih laboratory s normal level
boolean
C0032463 (UMLS CUI [1])
C0549448 (UMLS CUI [2])
Iron Overload | Hemochromatosis | Ferritin level | Transferrin saturation measurement
Item
iron overload syndromes, including hemochromatosis, or subjects with evidence of iron overload with a baseline ferritin level greater than 370 ng/ml and percent saturation of transferrin level greater than 40%.
boolean
C0282193 (UMLS CUI [1])
C0018995 (UMLS CUI [2])
C0427405 (UMLS CUI [3])
C1277709 (UMLS CUI [4])
Substance Use Disorders
Item
previous or current alcohol and/or substance abuse per medical history or medical records
boolean
C0038586 (UMLS CUI [1])
Medical contraindication MRI | Implants | Artificial cardiac pacemaker | Infusion Pump | Metallic implant | Metallic Object | Body Piercing Inconsistent MRI
Item
medical contraindications for mri (e.g., any non-organic implant or other device such as a cardiac pacemaker or infusion pump or other metallic implants, objects, or body piercings that are not mri-compatible or cannot be removed)
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0021102 (UMLS CUI [2])
C0030163 (UMLS CUI [3])
C0021436 (UMLS CUI [4])
C3693688 (UMLS CUI [5])
C2826620 (UMLS CUI [6])
C0848128 (UMLS CUI [7,1])
C0442809 (UMLS CUI [7,2])
C0024485 (UMLS CUI [7,3])
Contraindication Psychological MRI | Claustrophobia
Item
psychological contraindications for mri (e.g., claustrophobia), to be assessed at the time the medical history is collected
boolean
C0522473 (UMLS CUI [1,1])
C0205486 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
C0008909 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
pregnancy or current breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Hearing impairment
Item
reported history of clinically significant impaired hearing, because people with impaired hearing are at increased risk of sound-induced damage from the mri scanner
boolean
C1384666 (UMLS CUI [1])
Dextran allergy | Hypersensitivity Pharmaceutical Preparations Containing Iron salt | Severe allergic reaction Pharmaceutical Preparations | Anaphylaxis Pharmaceutical Preparations
Item
known allergy to dextran or drugs containing iron salts or any previous history of severe allergic reactions, anaphylaxis, to any drug
boolean
C0571755 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0013227 (UMLS CUI [2,2])
C0332256 (UMLS CUI [2,3])
C0302206 (UMLS CUI [2,4])
C2220378 (UMLS CUI [3,1])
C0013227 (UMLS CUI [3,2])
C0002792 (UMLS CUI [4,1])
C0013227 (UMLS CUI [4,2])
Disease At risk Patient Harm | Nervous system disorder At risk Patient Harm | Disease Interferes with Research results | Nervous system disorder Interferes with Research results | Disease Preventing Completion of clinical trial | Nervous system disorder Preventing Completion of clinical trial | Malignant Neoplasms | Condition Cardiopulmonary | Congestive heart failure | Uncontrolled hypertension
Item
clinically significant medical or neurological disorders that, in the judgment of the investigators might expose the patient to undue risk of harm confound study outcomes or prevent the participant from completing the study; examples of such conditions include but are not limited to diagnosis of certain types of cancer, cardiopulmonary conditions such as congestive heart failure, or uncontrolled hypertension
boolean
C0012634 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C3658342 (UMLS CUI [1,3])
C0027765 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C3658342 (UMLS CUI [2,3])
C0012634 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0683954 (UMLS CUI [3,3])
C0027765 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0683954 (UMLS CUI [4,3])
C0012634 (UMLS CUI [5,1])
C1292733 (UMLS CUI [5,2])
C2732579 (UMLS CUI [5,3])
C0027765 (UMLS CUI [6,1])
C1292733 (UMLS CUI [6,2])
C2732579 (UMLS CUI [6,3])
C0006826 (UMLS CUI [7])
C0348080 (UMLS CUI [8,1])
C0553534 (UMLS CUI [8,2])
C0018802 (UMLS CUI [9])
C1868885 (UMLS CUI [10])
Exclusion Criteria Additional
Item
additional patient exclusion criterion:
boolean
C0680251 (UMLS CUI [1,1])
C1524062 (UMLS CUI [1,2])
Gadolinium-Enhancing Lesion Quantity Screening CT scan
Item
4 or more gadolinium-enhancing lesions on the screening scan
boolean
C1333400 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0220908 (UMLS CUI [1,3])
C0040405 (UMLS CUI [1,4])