Multiple Sclerosis, Relapsing-Remitting | Multiple Sclerosis, Secondary Progressive | Enhancing Lesion New | Standard of Care Corticotropin
Item
patients with rrms or spms with new contrast-enhancing lesions who will start as part of their standard of care acth.
boolean
C0751967 (UMLS CUI [1])
C0751965 (UMLS CUI [2])
C3830314 (UMLS CUI [3,1])
C0205314 (UMLS CUI [3,2])
C2936643 (UMLS CUI [4,1])
C0001655 (UMLS CUI [4,2])
Adrenal Cortex Hormones Oral | Adrenal Cortex Hormones Intravenous | Enhancing Lesion
Item
patients having received oral or iv corticosteroids within one month prior to initial scan demonstrating contrast enhancing lesion
boolean
C0001617 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C0001617 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
C3830314 (UMLS CUI [3])
Hypersensitivity Corticotropin
Item
patients with known or new allergy to acth
boolean
C0020517 (UMLS CUI [1,1])
C0001655 (UMLS CUI [1,2])
natalizumab | rituximab | Cyclophosphamide
Item
patients being treated with natalizumab, rituximab, and cyclophosphamide
boolean
C1172734 (UMLS CUI [1])
C0393022 (UMLS CUI [2])
C0010583 (UMLS CUI [3])
MRI Repeated Unwilling
Item
patients unwilling to have serial mri exams
boolean
C0024485 (UMLS CUI [1,1])
C0205341 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
MRI Receive Unable | Heart Valve Prosthesis | Metal plate | Pins | Metallic Object Body | MRI scan Completion Unable
Item
patients unable to undergo mri imaging because of having an artificial heart valve, metal plate, pin, or other metallic objects in their body or is unable to complete all the mri scans required for this study
boolean
C0024485 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0018825 (UMLS CUI [2])
C0013866 (UMLS CUI [3])
C1168556 (UMLS CUI [4])
C2826620 (UMLS CUI [5,1])
C1318419 (UMLS CUI [5,2])
C0024485 (UMLS CUI [6,1])
C0205197 (UMLS CUI [6,2])
C1299582 (UMLS CUI [6,3])
Kidney Disease | Chronic Kidney Disease | Gadolinium At risk Nephrogenic Systemic Fibrosis
Item
patients with acute or chronic renal disease in whom administration of gadolinium may pose risk of nephrogenic systemic fibrosis
boolean
C0022658 (UMLS CUI [1])
C1561643 (UMLS CUI [2])
C0016911 (UMLS CUI [3,1])
C1444641 (UMLS CUI [3,2])
C3888044 (UMLS CUI [3,3])
Pregnancy
Item
patients that are pregnant
boolean
C0032961 (UMLS CUI [1])
Premenopausal state Contraceptive methods Unwilling
Item
premenopausal woman not willing to use at least one form of contraception
boolean
C0232969 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
Diabetes Mellitus
Item
patients with a known history of diabetes mellitus
boolean
C0011849 (UMLS CUI [1])
Osteoporosis | Bone Density Range Osteoporosis
Item
patients with a known history of osteoporosis or bone density values in the osteoporosis range at screening
boolean
C0029456 (UMLS CUI [1])
C0005938 (UMLS CUI [2,1])
C1514721 (UMLS CUI [2,2])
C0029456 (UMLS CUI [2,3])
Nervous system disorder Progressive | Exception Relapsing-Remitting Multiple Sclerosis | Exception Secondary Progressive Multiple Sclerosis
Item
progressive neurological disorder other than rrms or spms
boolean
C0027765 (UMLS CUI [1,1])
C0205329 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0751967 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0751965 (UMLS CUI [3,2])
Cardiovascular Disease | Myocardial Infarction | Myocardial Ischemia Unstable | Congestive heart failure | Angina Pectoris
Item
clinically significant cardiovascular disease, including myocardial infarct within last 6 months, unstable ischemic heart disease, congestive heart failure, or angina
boolean
C0007222 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0151744 (UMLS CUI [3,1])
C0443343 (UMLS CUI [3,2])
C0018802 (UMLS CUI [4])
C0002962 (UMLS CUI [5])
Steroid therapy chronic Multiple Sclerosis | Steroid therapy chronic Systemic disease
Item
subjects on chronic steroid therapy for treatment of ms or other systematic disease
boolean
C0149783 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0026769 (UMLS CUI [1,3])
C0149783 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
C0442893 (UMLS CUI [2,3])
Medical condition Study Subject Participation Status At risk | Medical condition Interferes with Research results | Exception Multiple Sclerosis | Nervous system disorder | Mental disorder | Metabolic Disease | Liver disease | Kidney Disease | Hematological Disease | Lung disease | Cardiovascular Disease | Uncontrolled hypertension | Gastrointestinal Disease | Urologic Disease | Central Nervous System Infection
Item
subject currently has a significant medical condition (other than ms) including the following: neurological, psychiatric, metabolic, hepatic, renal, hematological, pulmonary, cardiovascular (including uncontrolled hypertension), gastrointestinal, urological disorder, or central nervous system (cns) infection that would pose a risk to the subject if they were to participate in the study or that might confound the results of the study
boolean
C3843040 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C1444641 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0683954 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0026769 (UMLS CUI [3,2])
C0027765 (UMLS CUI [4])
C0004936 (UMLS CUI [5])
C0025517 (UMLS CUI [6])
C0023895 (UMLS CUI [7])
C0022658 (UMLS CUI [8])
C0018939 (UMLS CUI [9])
C0024115 (UMLS CUI [10])
C0007222 (UMLS CUI [11])
C1868885 (UMLS CUI [12])
C0017178 (UMLS CUI [13])
C0042075 (UMLS CUI [14])
C0007684 (UMLS CUI [15])
Medical condition Minor Eligible | Medical condition Well controlled Eligible
Item
o note: active medical conditions that are minor or well-controlled are not exclusionary if, in the judgment of the primary investigator, they do not affect risk or the subject or the study results.
boolean
C3843040 (UMLS CUI [1,1])
C0205165 (UMLS CUI [1,2])
C1548635 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C3853142 (UMLS CUI [2,2])
C1548635 (UMLS CUI [2,3])
Protocol Compliance Unable | Protocol Compliance Unlikely | Relocation of home Planned
Item
subject is unable to cooperate with any study procedures, unlikely to adhere to the study procedures and keep appointments, in the opinion of the investigator, or was planning to relocate during the study
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C0750558 (UMLS CUI [2,2])
C2699029 (UMLS CUI [3,1])
C1301732 (UMLS CUI [3,2])