Informed Consent
Item
must be able to provide written informed consent
boolean
C0021430 (UMLS CUI [1])
Age
Item
between 18-55 years of age at the time of informed consent.
boolean
C0001779 (UMLS CUI [1])
Multiple Sclerosis Type Any
Item
diagnosis of any form of ms as defined by the 2010 revised mcdonald criteria
boolean
C0026769 (UMLS CUI [1,1])
C0332307 (UMLS CUI [1,2])
C1552551 (UMLS CUI [1,3])
fingolimod | glatiramer acetate
Item
currently taking fingolimod or glatiramer acetate for a minimum of two years at the time of the initial baseline visit
boolean
C1699926 (UMLS CUI [1])
C0289884 (UMLS CUI [2])
Protocol Compliance
Item
must be willing and able to comply with the protocol requirements for the duration of the study
boolean
C0525058 (UMLS CUI [1])
Comorbidity Interferes with MRI Result | Comorbidity Contraindicated Fingolimod | Diabetes Mellitus | Myocardial Infarction | Angina, Unstable | Transient Ischemic Attack | Decompensated cardiac failure | Mobitz type II atrioventricular block | Complete atrioventricular block | Sick Sinus Syndrome | Cerebrovascular accident | Traumatic Brain Injury | Encephalitis | Dementia Independent of Multiple Sclerosis
Item
-patients suffering from comorbidities that could confound the mri outcomes or are (relative) contraindicated to receive treatment with fingolimod such as diabetes, myocardial infarction, unstable angina, transient ischemic attack, decompensated heart failure, history of mobitz type ii 2nd or 3rd degree atrioventricular block or sick sinus syndrome, history of stroke, traumatic brain injury, encephalitis, and dementia (not related to ms).
boolean
C0009488 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
C1274040 (UMLS CUI [1,4])
C0009488 (UMLS CUI [2,1])
C1444657 (UMLS CUI [2,2])
C1699926 (UMLS CUI [2,3])
C0011849 (UMLS CUI [3])
C0027051 (UMLS CUI [4])
C0002965 (UMLS CUI [5])
C0007787 (UMLS CUI [6])
C0581377 (UMLS CUI [7])
C0155700 (UMLS CUI [8])
C0151517 (UMLS CUI [9])
C0037052 (UMLS CUI [10])
C0038454 (UMLS CUI [11])
C0876926 (UMLS CUI [12])
C0014038 (UMLS CUI [13])
C0497327 (UMLS CUI [14,1])
C0332291 (UMLS CUI [14,2])
C0026769 (UMLS CUI [14,3])
Systemic steroids Oral | Systemic steroids Intravenous
Item
systemic steroid used (oral or iv) within 30 days of the baseline visit.
boolean
C2825233 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C2825233 (UMLS CUI [2,1])
C1522726 (UMLS CUI [2,2])
Chemotherapy
Item
patients who were ever treated with chemotherapy.
boolean
C0392920 (UMLS CUI [1])
Cranial Irradiation | Intracranial surgery
Item
patients ever having undergone cranial radiation, or intracranial surgery.
boolean
C0079172 (UMLS CUI [1])
C0745377 (UMLS CUI [2])
MRI scan Receive Unable | Pregnancy | Breast Feeding | Pregnancy, Planned
Item
patients who are unable to tolerate an mri scan. -patient who is pregnant or breastfeeding or planning on pregnancy during the study period-
boolean
C0024485 (UMLS CUI [1,1])
C1514756 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
C0032992 (UMLS CUI [4])
Handicap | Illiteracy | Blindness
Item
patient who is decisionally challenged, illiterate or blind
boolean
C0231172 (UMLS CUI [1])
C0020899 (UMLS CUI [2])
C0456909 (UMLS CUI [3])
Lacking Able to speak English Language
Item
patient is non-english speaking (as the pro instruments are only validated in english)
boolean
C0332268 (UMLS CUI [1,1])
C0564215 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])