Chronic Hepatitis C
Item
Does the participant have a chronic hepatitis c infection with a detectable hcv rna in the serum on two occasions, 6 months apart?
boolean
C0524910 (UMLS CUI [1,1])
C0855840 (UMLS CUI [1,2])
C0392762 (UMLS CUI [1,3])
C3830527 (UMLS CUI [1,4])
HSV Status
Item
Is the participant focus hsv-2 igg negative and focus hsv-1 igg positive, using manufacturer's cut-offs?
boolean
C0019351 (UMLS CUI [1,1])
C0205160 (UMLS CUI [1,2])
C0206679 (UMLS CUI [2,1])
C1446409 (UMLS CUI [2,2])
Prior Treatment
Item
Does the participant have had antiherpes or immunomodulatory therapy during the past 30 days?
boolean
C1514463 (UMLS CUI [1,1])
C0019369 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
C1963758 (UMLS CUI [2,1])
C0332185 (UMLS CUI [2,2])
HIV and chronic Hepatitis C
Item
Does the participant have hiv or chronic hepatitis b infection?
boolean
C0019693 (UMLS CUI [1])
C0524909 (UMLS CUI [2])
Decompensated liver disease
Item
Does the participant have decompensated liver disease (ascites, hepatic encephalopathy, coagulopathy, jaundice/icterus)?
boolean
C4075847 (UMLS CUI [1])
C0003962 (UMLS CUI [2])
C0019151 (UMLS CUI [3])
C0005779 (UMLS CUI [4])
C0022346 (UMLS CUI [5])
Creatinine Clearance
Item
Does the participant have a creatinine clearance <50 ml/min.?
boolean
C0373595 (UMLS CUI [1])
Pregnancy or Peripartum
Item
Is the female participant is pregnant or nursing?
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Gastrointestinal disorder
Item
Does the participant have a gastrointestinal disorder which might result in malabsorption of valacyclovir?
boolean
C0017178 (UMLS CUI [1,1])
C3714745 (UMLS CUI [1,2])
C0249458 (UMLS CUI [1,3])
Erythema multiforme major, Thrombotic thrombocytopenia purpura or hemolytic uremic syndrome
Item
Does the participant have a history of erythema multiforme major, thrombotic thrombocytopenia purpura or hemolytic uremic syndrome?
boolean
C0262926 (UMLS CUI [1,1])
C0857305 (UMLS CUI [1,2])
C0262926 (UMLS CUI [2,1])
C0019061 (UMLS CUI [2,2])
C0262926 (UMLS CUI [3,1])
C3241919 (UMLS CUI [3,2])
Valacyclovir allergy
Item
Does the participant have an allergy to valacyclovir or related drug?
boolean
C0249458 (UMLS CUI [1,1])
C0020517 (UMLS CUI [1,2])