Multiple Myeloma Symptomatic | Measurable Disease secretory
Item
confirmed diagnosis of symptomatic multiple myeloma and measurable secretory disease
boolean
C0026764 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C1327616 (UMLS CUI [2,2])
ECOG performance status
Item
eastern cooperative oncology group performance status score of 0, 1, or 2
boolean
C1520224 (UMLS CUI [1])
Laboratory Results pre treatment | Study Protocol Parameters Fulfill
Item
pretreatment clinical laboratory values must meet protocol-defined parameters during the screening phase
boolean
C1254595 (UMLS CUI [1,1])
C2709094 (UMLS CUI [1,2])
C2348563 (UMLS CUI [2,1])
C0449381 (UMLS CUI [2,2])
C1550543 (UMLS CUI [2,3])
daratumumab | Therapeutic procedure Against CD38 Antigen
Item
previously received daratumumab or other anti-cd38 therapies
boolean
C2346801 (UMLS CUI [1])
C0087111 (UMLS CUI [2,1])
C0521124 (UMLS CUI [2,2])
C0075742 (UMLS CUI [2,3])
Primary amyloidosis | Monoclonal Gammopathy | Smoldering myeloma | Waldenstrom Macroglobulinemia | Condition Immunoglobulin M Present | Absence Plasma cell infiltration Clonal | Absence Lytic bone lesion
Item
diagnosis of primary amyloidosis, monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, waldenström's disease, or other conditions in which igm m-protein is present in the absence of a clonal plasma cell infiltration with lytic bone lesions
boolean
C0268381 (UMLS CUI [1])
C1136085 (UMLS CUI [2])
C1531608 (UMLS CUI [3])
C0024419 (UMLS CUI [4])
C0348080 (UMLS CUI [5,1])
C0020861 (UMLS CUI [5,2])
C0150312 (UMLS CUI [5,3])
C0332197 (UMLS CUI [6,1])
C0391861 (UMLS CUI [6,2])
C1522642 (UMLS CUI [6,3])
C0332197 (UMLS CUI [7,1])
C0221204 (UMLS CUI [7,2])
Peripheral Neuropathy CTCAE grades | Neuropathic pain CTCAE grades
Item
peripheral neuropathy or neuropathic pain grade 2 or higher
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C3714625 (UMLS CUI [2,1])
C1516728 (UMLS CUI [2,2])
Invasive cancer | Exception Multiple Myeloma
Item
prior or concurrent invasive malignancy (other than multiple myeloma) within 5 years of study start
boolean
C0677898 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0026764 (UMLS CUI [2,2])
Sign or Symptom Meninges Involvement with Multiple Myeloma
Item
exhibiting clinical signs of meningeal involvement of multiple myeloma
boolean
C3540840 (UMLS CUI [1,1])
C0025285 (UMLS CUI [1,2])
C1314939 (UMLS CUI [1,3])
C0026764 (UMLS CUI [1,4])
Chronic Obstructive Airway Disease | Persistent asthma | Asthma
Item
known chronic obstructive pulmonary disease, persistent asthma, or a history of asthma within 2 years
boolean
C0024117 (UMLS CUI [1])
C3266628 (UMLS CUI [2])
C0004096 (UMLS CUI [3])
HIV Seropositivity | Hepatitis B Seropositive | Hepatitis C Seropositive
Item
seropositive for human immunodeficiency virus, hepatitis b, or hepatitis c
boolean
C0019699 (UMLS CUI [1])
C0019163 (UMLS CUI [2,1])
C0521143 (UMLS CUI [2,2])
C0019196 (UMLS CUI [3,1])
C0521143 (UMLS CUI [3,2])
Medical condition Interferes with Clinical Trial | Mental condition Interferes with Clinical Trial | Medical condition Interferes with Research results | Mental condition Interferes with Research results | Medical condition Study Subject Participation Status At risk | Mental condition Study Subject Participation Status At risk
Item
any concurrent medical or psychiatric condition or disease that is likely to interfere with the study procedures or results, or that in the opinion of the investigator, would constitute a hazard for participating in this study
boolean
C3843040 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0008976 (UMLS CUI [1,3])
C3840291 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0008976 (UMLS CUI [2,3])
C3843040 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C0683954 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C0683954 (UMLS CUI [4,3])
C3843040 (UMLS CUI [5,1])
C2348568 (UMLS CUI [5,2])
C1444641 (UMLS CUI [5,3])
C3840291 (UMLS CUI [6,1])
C2348568 (UMLS CUI [6,2])
C1444641 (UMLS CUI [6,3])
Heart Disease
Item
clinically significant cardiac disease
boolean
C0018799 (UMLS CUI [1])
Leukemia, Plasma Cell | POEMS Syndrome
Item
plasma cell leukemia or poems (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes) syndrome
boolean
C0023484 (UMLS CUI [1])
C0085404 (UMLS CUI [2])