Age
Item
men and women ≥ 18 years of age
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0 to 1
boolean
C1520224 (UMLS CUI [1])
Colorectal Carcinoma
Item
histologically confirmed colorectal cancer
boolean
C0009402 (UMLS CUI [1])
Measurable Disease CT | Measurable Disease MRI
Item
measurable disease by ct or mri
boolean
C1513041 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C0024485 (UMLS CUI [2,2])
Microsatellite instability diagnostic test
Item
testing for msi status
boolean
C0796369 (UMLS CUI [1])
Organ function Laboratory Procedures
Item
adequate organ function as defined by study-specific laboratory tests
boolean
C0678852 (UMLS CUI [1,1])
C0022885 (UMLS CUI [1,2])
Childbearing Potential Contraceptive methods | Gender Partner Childbearing Potential | Gender Sexually active Contraceptive methods
Item
must use acceptable form of birth control throughout the study. after the final dose of study drug, an acceptable form of birth control must be used for 23 weeks for women of childbearing potential (wocbp) and 31 weeks for men who are sexually active with wocbp
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0682323 (UMLS CUI [2,2])
C3831118 (UMLS CUI [2,3])
C0079399 (UMLS CUI [3,1])
C0241028 (UMLS CUI [3,2])
C0700589 (UMLS CUI [3,3])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Protocol Compliance
Item
willing and able to comply with study procedures
boolean
C0525058 (UMLS CUI [1])
Metastatic malignant neoplasm to brain | Metastatic Malignant Neoplasm to the Leptomeninges
Item
active brain metastases or leptomeningeal metastases are not allowed.
boolean
C0220650 (UMLS CUI [1])
C1704231 (UMLS CUI [2])
Anti-PD1 Monoclonal Antibody | Anti-PD-L1 Monoclonal Antibody | PD-L2 Monoclonal Antibody | Anti-CTLA-4 Monoclonal Antibody
Item
prior treatment with an anti-programmed death receptor (pd)-1, anti-pd-l1, anti-pd-l2, anti-cytotoxic t-cell lymphoma-4 antigen (ctla-4) antibody, or any other antibody or drug specifically targeting t-cell co-stimulation or immune checkpoint pathways
boolean
C4289970 (UMLS CUI [1])
C4289971 (UMLS CUI [2])
C1705357 (UMLS CUI [3,1])
C0003250 (UMLS CUI [3,2])
C4289973 (UMLS CUI [4])
Malignant Neoplasms | Exception Malignant Neoplasms Cured Locally
Item
prior malignancy active within the previous 3 years except for locally curable cancers
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
C1880198 (UMLS CUI [2,3])
C1517927 (UMLS CUI [2,4])
Autoimmune Disease | Autoimmune Disease Suspected
Item
subjects with active, known or suspected autoimmune disease
boolean
C0004364 (UMLS CUI [1])
C0004364 (UMLS CUI [2,1])
C0750491 (UMLS CUI [2,2])
Condition Requirement Systemic therapy | Adrenal Cortex Hormones | Immunosuppressive Agents
Item
subjects with a condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications within 14 days of study drug administration
boolean
C0348080 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1515119 (UMLS CUI [1,3])
C0001617 (UMLS CUI [2])
C0021081 (UMLS CUI [3])