Measurable Disease Quantity | Lesion Dimensional Measurement Accuracy Longest Diameter | Lesion size Minimum CT scan | Exception Lymph nodes Short axis | Operative Surgical Procedures Absent | Therapeutic radiology procedure Absent | Radiofrequency ablation Absent | Exception Disease Progression | Solid Neoplasm Refractory Standard therapy | Exception Liver carcinoma | Standard therapy Unavailable | Recurrent Head and Neck Squamous Cell Carcinoma Inappropriate Curative Surgery | Recurrent Head and Neck Squamous Cell Carcinoma Inappropriate Curative Therapeutic radiology procedure | HEAD NECK CANCER SQUAMOUS CELL METASTATIC Inappropriate Curative Surgery | HEAD NECK CANCER SQUAMOUS CELL METASTATIC Inappropriate Curative Therapeutic radiology procedure | Squamous cell carcinoma of the head and neck Oral cavity | Squamous cell carcinoma of the head and neck Oropharynx | Squamous cell carcinoma of the head and neck Larynx | Squamous cell carcinoma of the head and neck Hypopharynx | Tumor Lesion Amenable Biopsy | Chemotherapy Platinum-Based failed | Chemotherapy Platinum-Based Refused | Ineligibility Chemotherapy Platinum-Based | Recurrent Head and Neck Squamous Cell Carcinoma | HEAD NECK CANCER SQUAMOUS CELL METASTATIC
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has measurable disease, defined as at least 1 lesion that can be accurately measured in at least 1 dimension (longest diameter to be recorded) with a minimum size of 10 mm by computerised tomography (ct) scan, except lymph nodes which must have minimum short axis size of 15 mm (ct scan slice thickness no greater than 5 mm in both cases). indicator lesions must not have been previously treated with surgery, radiation therapy, or radiofrequency ablation unless there is documented progression after therapy. - part a: has a histological confirmation of a solid malignancy (other than hcc) that is refractory to standard therapy or for which no standard of care regimen currently exists. - part b:has histologically and/or cytologically confirmed scchn that is rm and not amendable to curative therapy by surgery or radiation. squamous cell carcinoma of the head and neck originating from the following sites is eligible: oral cavity, oropharynx, larynx, or hypopharynx -part b: has at least 1 scchn tumour lesion (tl) amenable to biopsy and must be medically fit and willing to undergo a biopsy during screening and, unless clinically contraindicated, at the end of cycle 1. (in the event of pd, biopsies at the end of treatment are optional but encouraged.) tumour lesions used for biopsy should not be lesions used as recist tls, unless there are no other lesions suitable for biopsy. if a recist tl is used for biopsy, the lesion must be ≥2 cm in longest diameter. -part b: must have failed, refused, or has been found to be ineligible for least 1 prior platinum-based chemotherapy for rm-scchn
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0221198 (UMLS CUI [2,1])
C3494215 (UMLS CUI [2,2])
C0552406 (UMLS CUI [2,3])
C0449453 (UMLS CUI [3,1])
C1524031 (UMLS CUI [3,2])
C0040405 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0024204 (UMLS CUI [4,2])
C0522488 (UMLS CUI [4,3])
C0543467 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C1522449 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0850292 (UMLS CUI [7,1])
C0332197 (UMLS CUI [7,2])
C1705847 (UMLS CUI [8,1])
C0242656 (UMLS CUI [8,2])
C0280100 (UMLS CUI [9,1])
C0205269 (UMLS CUI [9,2])
C2936643 (UMLS CUI [9,3])
C1705847 (UMLS CUI [10,1])
C2239176 (UMLS CUI [10,2])
C2936643 (UMLS CUI [11,1])
C0686905 (UMLS CUI [11,2])
C4524839 (UMLS CUI [12,1])
C1548788 (UMLS CUI [12,2])
C1273390 (UMLS CUI [12,3])
C0543467 (UMLS CUI [12,4])
C4524839 (UMLS CUI [13,1])
C1548788 (UMLS CUI [13,2])
C1273390 (UMLS CUI [13,3])
C1522449 (UMLS CUI [13,4])
C0744620 (UMLS CUI [14,1])
C1548788 (UMLS CUI [14,2])
C1273390 (UMLS CUI [14,3])
C0543467 (UMLS CUI [14,4])
C0744620 (UMLS CUI [15,1])
C1548788 (UMLS CUI [15,2])
C1273390 (UMLS CUI [15,3])
C1522449 (UMLS CUI [15,4])
C1168401 (UMLS CUI [16,1])
C0226896 (UMLS CUI [16,2])
C1168401 (UMLS CUI [17,1])
C0521367 (UMLS CUI [17,2])
C1168401 (UMLS CUI [18,1])
C0023078 (UMLS CUI [18,2])
C1168401 (UMLS CUI [19,1])
C0020629 (UMLS CUI [19,2])
C0027651 (UMLS CUI [20,1])
C0221198 (UMLS CUI [20,2])
C3900053 (UMLS CUI [20,3])
C0005558 (UMLS CUI [20,4])
C0392920 (UMLS CUI [21,1])
C1514162 (UMLS CUI [21,2])
C0231175 (UMLS CUI [21,3])
C0392920 (UMLS CUI [22,1])
C1514162 (UMLS CUI [22,2])
C1705116 (UMLS CUI [22,3])
C1512714 (UMLS CUI [23,1])
C0392920 (UMLS CUI [23,2])
C1514162 (UMLS CUI [23,3])
C4524839 (UMLS CUI [24])
C0744620 (UMLS CUI [25])