Age
Item
age≥18 years, ≤75 years, male or female
boolean
C0001779 (UMLS CUI [1])
Renal Cell Carcinoma Advanced
Item
advanced renal cell carcinoma is diagnosed histologically or pathologically
boolean
C0007134 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
Therapy naive
Item
treatment naive at diagnosed
boolean
C0919936 (UMLS CUI [1])
Measurable lesion Quantity
Item
at least one measurable tumor lesion (response evaluation criteria in solid tumors)
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
ECOG performance status
Item
eastern cooperative oncology group(ecog) performance scale is 0 or 1
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
the expected life span is ≥12 weeks
boolean
C0023671 (UMLS CUI [1])
Medical contraindication Absent Targeted Therapy | Liver function | Renal function | Hematologic function | Neutrophil count | Platelet Count measurement | Hemoglobin measurement | Creatinine measurement, serum | Liver Dysfunction Without Neoplasm Metastasis | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Liver Dysfunction metastatic
Item
no contraindications for targeted therapy, with enough liver function and renal function and normal ecg recording peripheral hemogram: neutrophil≥1.5×109/l, plt≥100×109/l, hgb≥90g/l renal function: serum creatinine≤1.5 folds the upper limit of normal (uln) for patients with non-metastatic liver dysfunction:alanine aminotransferase and aspartate aminotransferase≤2.5 uln, for patients with metastatic liver dysfunction: alanine aminotransferase and aspartate aminotransferase≤5 uln
boolean
C1301624 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C2985566 (UMLS CUI [1,3])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
C0221130 (UMLS CUI [4])
C0200633 (UMLS CUI [5])
C0032181 (UMLS CUI [6])
C0518015 (UMLS CUI [7])
C0201976 (UMLS CUI [8])
C0086565 (UMLS CUI [9,1])
C0332288 (UMLS CUI [9,2])
C0027627 (UMLS CUI [9,3])
C0201836 (UMLS CUI [10])
C0201899 (UMLS CUI [11])
C0086565 (UMLS CUI [12,1])
C1522484 (UMLS CUI [12,2])
Informed Consent
Item
the patients participate voluntarily and have signed the informed consent form
boolean
C0021430 (UMLS CUI [1])
Systemic therapy | Targeted Therapy | Immunotherapy | Chemotherapy
Item
patients who have received any systemic therapy including targeted therapy,immunotherapy,chemotherapy etc at diagnosed.
boolean
C1515119 (UMLS CUI [1])
C2985566 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C0392920 (UMLS CUI [4])
Pregnancy | Breast Feeding | Childbearing Potential Contraceptive methods Absent
Item
pregnant and lactating women, or female patients of child-bearing age without taking contraceptive measures
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0332197 (UMLS CUI [3,3])
Communicable Disease Severe Poorly controlled | Infection pyogenic | Chronic infectious disease | Non-healed wound Persistent
Item
patients with severe acute infection without being controlled effectively or having pyogenic and chronic infections with persistently unhealed wounds
boolean
C0009450 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C3853134 (UMLS CUI [1,3])
C0858906 (UMLS CUI [2])
C0151317 (UMLS CUI [3])
C0750433 (UMLS CUI [4,1])
C0205322 (UMLS CUI [4,2])
Heart Diseases Serious | Cardiac function New York Heart Association Classification
Item
past history of serious heart diseases, including: cardiac function classification
boolean
C0018799 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0232164 (UMLS CUI [2,1])
C1275491 (UMLS CUI [2,2])
Angina, Unstable | Myocardial Infarction | Cardiac Arrhythmia Requirement Anti-Arrhythmia Agents | Exception Adrenergic beta-1 Receptor Antagonists | Exception Digoxin | Uncontrolled hypertension
Item
≥nyha class ii, unstable angina pectoris, myocardial infarction, arrhythmia requiring anti-arrhythmic drug therapy (excluding β-blockers or digoxin), and uncontrolled hypertension
boolean
C0002965 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0003811 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C0003195 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0304516 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0012265 (UMLS CUI [5,2])
C1868885 (UMLS CUI [6])
HIV Infection | Hepatitis B, Chronic | Hepatitis C, Chronic
Item
patients with a history of hiv infection or active phase of chronic hepatitis b/c
boolean
C0019693 (UMLS CUI [1])
C0524909 (UMLS CUI [2])
C0524910 (UMLS CUI [3])
Imaging Negative
Item
negative imaging examination result 4 weeks prior to enrollment)
boolean
C0011923 (UMLS CUI [1,1])
C1513916 (UMLS CUI [1,2])
Epilepsy Requirement Pharmacotherapy | Steroids | Antiepileptic Agents
Item
epilepsy patients requiring drug therapy (e.g. steroids or antiepileptic drugs)
boolean
C0014544 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0013216 (UMLS CUI [1,3])
C0038317 (UMLS CUI [2])
C0003299 (UMLS CUI [3])
Organ Transplantation Allogeneic
Item
a history of allogeneic organ transplantation
boolean
C0029216 (UMLS CUI [1,1])
C1515895 (UMLS CUI [1,2])