Non-Small Cell Lung Carcinoma TNM clinical staging
Item
cytologically or histologically confirmed diagnosis of stage iv nsclc as defined by the american joint committee on cancer staging criteria for lung cancer (ajcc 7th edition 2009).
boolean
C0007131 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Eligibility First line treatment Erlotinib | Neoplasm EGFR Activating Mutation | Loss of Chromosome 19 | EGFR Activating Mutation L858R
Item
eligible for first-line treatment with erlotinib based on documented evidence of tumor harboring an activating egfr mutation (example 19 del and l858r).
boolean
C1548635 (UMLS CUI [1,1])
C1708063 (UMLS CUI [1,2])
C1135135 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2,1])
C2984891 (UMLS CUI [2,2])
C1517970 (UMLS CUI [3])
C3274204 (UMLS CUI [4])
Non-Small Cell Lung Carcinoma Tissue specimen TNM clinical staging
Item
mandatory provision of adequate archived stage iv nsclc tissue sample.
boolean
C0007131 (UMLS CUI [1,1])
C1292533 (UMLS CUI [1,2])
C3258246 (UMLS CUI [1,3])
Measurable lesion Quantity
Item
at least one measurable lesion.
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Life Expectancy
Item
life expectancy of at least 3 months.
boolean
C0023671 (UMLS CUI [1])
EGFR T790M
Item
known t790m egfr mutation.
boolean
C3274192 (UMLS CUI [1])
Meningeal Carcinomatosis Uncontrolled | Compression of spinal cord Unstable | Metastatic malignant neoplasm to brain
Item
known leptomeningeal carcinomatosis, uncontrolled/unstable spinal cord compression, or brain metastases.
boolean
C0220654 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0037926 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
C0220650 (UMLS CUI [3])
Illness Serious | Medical condition Serious
Item
serious illness or medical condition.
boolean
C0221423 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C3843040 (UMLS CUI [2,1])
C0205404 (UMLS CUI [2,2])
CYP3A4 Inducers | CYP3A4 Inhibitors Strong | CYP3A4 Inhibitors Moderate
Item
ongoing treatment with cyp3a4 inducers or strong/moderate inhibitors.
boolean
C3850041 (UMLS CUI [1])
C3850053 (UMLS CUI [2,1])
C0442821 (UMLS CUI [2,2])
C3850053 (UMLS CUI [3,1])
C0205081 (UMLS CUI [3,2])
Anti-Inflammatory Agents, Non-Steroidal
Item
ongoing therapy with nonsteroidal anti-inflammatory drugs for more than 2 months.
boolean
C0003211 (UMLS CUI [1])
Hemoptysis Severe
Item
history of gross hemoptysis.
boolean
C0019079 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Blood Coagulation Disorders
Item
significant bleeding disorders.
boolean
C0005779 (UMLS CUI [1])
Tumor Invasion Blood Vessel Major
Item
radiologically documented evidence of major blood vessel invasion or encasement by cancer.
boolean
C1269955 (UMLS CUI [1,1])
C0005847 (UMLS CUI [1,2])
C0205164 (UMLS CUI [1,3])
Tumour cavitation
Item
radiographic evidence of intratumor cavitation.
boolean
C4524108 (UMLS CUI [1])
Gastrointestinal perforation
Item
history of gastrointestinal perforation within last 6 months.
boolean
C0151664 (UMLS CUI [1])
Intestinal Obstruction | Intestinal Disease inflammatory | Intestinal resection Extensive
Item
history of bowel obstruction, inflammatory enteropathy or extensive intestinal resection.
boolean
C0021843 (UMLS CUI [1])
C0021831 (UMLS CUI [2,1])
C0333348 (UMLS CUI [2,2])
C1096244 (UMLS CUI [3,1])
C0205231 (UMLS CUI [3,2])
Arterial thrombosis
Item
history of any arterial thrombotic event within 6 months prior to enrollment.
boolean
C0151942 (UMLS CUI [1])
Abnormality Surface of eye
Item
the participant has any known significant ophthalmologic abnormalities of the surface of the eye.
boolean
C1704258 (UMLS CUI [1,1])
C4321570 (UMLS CUI [1,2])