Age
Item
aged above 18 years.
boolean
C0001779 (UMLS CUI [1])
Adenocarcinoma of colon metastatic | Adenocarcinoma of rectum metastatic
Item
pathologically confirmed metastatic adenocarcinoma of the colon or rectum. all other histological types are excluded.
boolean
C4324497 (UMLS CUI [1])
C0149978 (UMLS CUI [2,1])
C1522484 (UMLS CUI [2,2])
Second line treatment failed | fluoropyrimidine | irinotecan | oxaliplatin | Disease Progression Following Standard therapy | Standard therapy Discontinued Due to Toxicity | Recurrent disease | Neoplasm Metastasis | Adjuvant Chemotherapy First line treatment | Capecitabine Absent
Item
failure of second-line and more than second-line treatment, and fluoropyrimidine- and irinotecan- and oxaliplatin-containing regimens.(subjects who progress during or within 3 months following the last administration of approved standard therapies and terminate standard treatment due to unacceptable toxicity warranting.).if recurrence and metastasis occurred within 6 months after discontinuation of adjuvant chemotherapy, the adjuvant chemotherapy is considered to be first-line treatment.subject received last-line treatment not including capecitabine.
boolean
C1710038 (UMLS CUI [1,1])
C0231175 (UMLS CUI [1,2])
C0596581 (UMLS CUI [2])
C0123931 (UMLS CUI [3])
C0069717 (UMLS CUI [4])
C0242656 (UMLS CUI [5,1])
C0332282 (UMLS CUI [5,2])
C2936643 (UMLS CUI [5,3])
C2936643 (UMLS CUI [6,1])
C1444662 (UMLS CUI [6,2])
C0678226 (UMLS CUI [6,3])
C0600688 (UMLS CUI [6,4])
C0277556 (UMLS CUI [7])
C0027627 (UMLS CUI [8])
C0085533 (UMLS CUI [9,1])
C1708063 (UMLS CUI [9,2])
C0671970 (UMLS CUI [10,1])
C0332197 (UMLS CUI [10,2])
Measurable Disease Quantity | Lesion size Spiral CT | Lesion size MRI | Lymph nodes Malignant Diameter Spiral CT
Item
at least one measurable lesion according to the recist criteria that has not been previously local treated. minimum indicator lesion size as follows: greater than or equal to 10 mm measured by spiral ct or nmr.malignant lymph nodes short diameter as follows: greater than or equal to 15 mm measured by spiral ct.
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0449453 (UMLS CUI [2,1])
C0860888 (UMLS CUI [2,2])
C0449453 (UMLS CUI [3,1])
C0024485 (UMLS CUI [3,2])
C0024204 (UMLS CUI [4,1])
C0205282 (UMLS CUI [4,2])
C1301886 (UMLS CUI [4,3])
C0860888 (UMLS CUI [4,4])
ECOG performance status
Item
ecog performance status 0, 1 or 2.
boolean
C1520224 (UMLS CUI [1])
Therapeutic radiology procedure Local Symptom control | Operative Surgical Procedures Local Symptom control | Therapeutic radiology procedure Local | Operative Surgical Procedures Local | Control Complications Severe | Toxicity Due to Prior Therapy | Patient recovered
Item
minimum of 4 weeks since any local radiotherapy or surgery for the control of symptoms or severe complications(local radiotherapy for the control of bone metastases is not the limit),and adequately recovered from toxicities of any prior therapy).
boolean
C1522449 (UMLS CUI [1,1])
C0205276 (UMLS CUI [1,2])
C1274136 (UMLS CUI [1,3])
C0543467 (UMLS CUI [2,1])
C0205276 (UMLS CUI [2,2])
C1274136 (UMLS CUI [2,3])
C1522449 (UMLS CUI [3,1])
C0205276 (UMLS CUI [3,2])
C0543467 (UMLS CUI [4,1])
C0205276 (UMLS CUI [4,2])
C2587213 (UMLS CUI [5,1])
C0009566 (UMLS CUI [5,2])
C0205082 (UMLS CUI [5,3])
C0600688 (UMLS CUI [6,1])
C0678226 (UMLS CUI [6,2])
C1514463 (UMLS CUI [6,3])
C1115804 (UMLS CUI [7])
Life Expectancy
Item
life expectancy of at least 3 months.
boolean
C0023671 (UMLS CUI [1])
Novaferon
Item
prior treatment with novaferon.
boolean
C3273451 (UMLS CUI [1])
Pregnancy | Breast Feeding | Possible pregnancy | Pregnancy test positive
Item
pregnancy or breast-feeding women or women who may be pregnant were positive drug test before administration.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0425965 (UMLS CUI [3])
C0240802 (UMLS CUI [4])
Females & males of reproductive potential Contraceptive methods Unwilling
Item
patient of child-bearing potential(male or less than 1 year postmenopausal women) were reluctant to take contraceptive measures.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
Hypersensitivity Interferon-alpha | Interferon-alpha Antibody
Item
patient who were allergic to interferon-α or who had interferon-α antibody.
boolean
C0020517 (UMLS CUI [1,1])
C0002199 (UMLS CUI [1,2])
C0002199 (UMLS CUI [2,1])
C0003241 (UMLS CUI [2,2])
CNS metastases Uncontrolled
Item
patients with uncontrolled central nervous system (cns) metastases.
boolean
C0686377 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])