Breast Carcinoma
Item
histologically confirmed diagnosis of breast cancer.
boolean
C0678222 (UMLS CUI [1])
Neoplasm Metastasis
Item
presence of metastatic disease.
boolean
C0027627 (UMLS CUI [1])
HER2 gene amplification | HER2 Protein Overexpression
Item
documentation of her2 gene amplification or overexpression.
boolean
C1512127 (UMLS CUI [1])
C1515560 (UMLS CUI [2])
Tumor tissue sample Available | Review of HER2 Status
Item
available tumor tissue for central review of her2 status.
boolean
C0475358 (UMLS CUI [1,1])
C0470187 (UMLS CUI [1,2])
C0699752 (UMLS CUI [2,1])
C1512413 (UMLS CUI [2,2])
Measurable lesion Quantity
Item
at least 1 measurable lesion as defined by recist 1.1.
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
ECOG performance status
Item
eastern cooperative oncology group status of 0 to 2.
boolean
C1520224 (UMLS CUI [1])
Left ventricular ejection fraction Within reference range Echocardiography 2-Dimensional | Left ventricular ejection fraction Within reference range MUGA scan
Item
left ventricular ejection fraction within institutional range of normal, measured by either two dimensional echocardiogram or multigated acquisition scan.
boolean
C0428772 (UMLS CUI [1,1])
C0460094 (UMLS CUI [1,2])
C0013516 (UMLS CUI [1,3])
C1705052 (UMLS CUI [1,4])
C0428772 (UMLS CUI [2,1])
C0460094 (UMLS CUI [2,2])
C0521317 (UMLS CUI [2,3])
Recurrent disease | Adjuvant therapy | Neoadjuvant Therapy | Exception Hormone Therapy
Item
relapse within 1 year of last dose of previous adjuvant (including neoadjuvant) treatment (except endocrine therapy).
boolean
C0277556 (UMLS CUI [1])
C0677850 (UMLS CUI [2])
C0600558 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0279025 (UMLS CUI [4,2])
Systemic therapy Neoplasm Metastasis | Exception Hormone Therapy
Item
prior systemic therapy for metastatic disease (except endocrine therapy).
boolean
C1515119 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0279025 (UMLS CUI [2,2])
Doxorubicin Cumulative Dose | Epirubicin Dose | Anthracyclines Dose Equivalent | Derivative Dose Equivalent | Mitoxantrone Dose
Item
prior cumulative dose of doxorubicin of >400 mg/m2, epirubicin dose >800 mg/m^2, or the equivalent dose for other anthracyclines or derivatives (eg, 72 mg/m^2 of mitoxantrone). if the patient has received more than one anthracycline, then the cumulative dose must not exceed the equivalent of 400 mg/m^2 of doxorubicin.
boolean
C0013089 (UMLS CUI [1,1])
C2986497 (UMLS CUI [1,2])
C0014582 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0282564 (UMLS CUI [3,1])
C0178602 (UMLS CUI [3,2])
C0205163 (UMLS CUI [3,3])
C1527240 (UMLS CUI [4,1])
C0178602 (UMLS CUI [4,2])
C0205163 (UMLS CUI [4,3])
C0026259 (UMLS CUI [5,1])
C0178602 (UMLS CUI [5,2])
Inflammatory Breast Carcinoma
Item
inflammatory breast cancer.
boolean
C0278601 (UMLS CUI [1])
CNS metastases Uncontrolled | CNS metastases Symptomatic
Item
active uncontrolled or symptomatic central nervous system metastases.
boolean
C0686377 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])