Age
Item
male or female participants, 18-70 years of age;
boolean
C0001779 (UMLS CUI [1])
Healthy Volunteers | Mental disorders Free of | DEPRESSIVE DISORDER MAJOR WITHOUT PSYCHOTIC FEATURE
Item
participants must be free of any psychiatric condition (for the healthy volunteer group) or meet dsm-iv criteria for major depressive disorder, without psychotic features, based on the structured clinical interview for dsm-iv tr axis i disorders (scid);
boolean
C1708335 (UMLS CUI [1])
C0004936 (UMLS CUI [2,1])
C0332296 (UMLS CUI [2,2])
C0743081 (UMLS CUI [3])
Antidepressant therapy Response Inadequate | Antidepressant therapy Quantity Major depressive episode | Depressive Disorder, Treatment-Resistant
Item
participants have demonstrated inadequate response to a minimum of 1 adequate antidepressant treatment trial in current episode (e.g. trd);
boolean
C1096649 (UMLS CUI [1,1])
C1704632 (UMLS CUI [1,2])
C0205412 (UMLS CUI [1,3])
C1096649 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0024517 (UMLS CUI [2,3])
C2063866 (UMLS CUI [3])
Washout Psychotropic Drugs
Item
participants must be willing to undergo washout of psychotropic medications that he or she is taking;
boolean
C1710661 (UMLS CUI [1,1])
C0033978 (UMLS CUI [1,2])
Comprehension Level English Language | Protocol Compliance | Informed Consent
Item
participants must have a level of understanding of the english language sufficient to agree to all tests and examinations required by the study and must be able to participate fully in the informed consent process.
boolean
C0233733 (UMLS CUI [1,1])
C0441889 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])
C0525058 (UMLS CUI [2])
C0021430 (UMLS CUI [3])
Schizophrenia Lifetime | Psychotic Disorders Lifetime | Bipolar Disorder Lifetime | Pervasive Development Disorder Lifetime | Mental Retardation Lifetime
Item
lifetime diagnosis of schizophrenia or any psychotic disorder, bipolar disorder, pervasive developmental disorders or mental retardation;
boolean
C0036341 (UMLS CUI [1,1])
C4071830 (UMLS CUI [1,2])
C0033975 (UMLS CUI [2,1])
C4071830 (UMLS CUI [2,2])
C0005586 (UMLS CUI [3,1])
C4071830 (UMLS CUI [3,2])
C0524528 (UMLS CUI [4,1])
C4071830 (UMLS CUI [4,2])
C0025362 (UMLS CUI [5,1])
C4071830 (UMLS CUI [5,2])
Obsessive-Compulsive Disorder | Anxiety Disorders Other Absent
Item
current diagnosis of obsessive-compulsive disorder (ocd), but not other anxiety disorders;
boolean
C0028768 (UMLS CUI [1])
C0003469 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Substance Use Disorders | Urinalysis Toxicologic Negative
Item
diagnosis of a substance use disorder within the past six months; all participants must have a negative urine toxicology test on the day of the fmri, prior to the scan;
boolean
C0038586 (UMLS CUI [1])
C0042014 (UMLS CUI [2,1])
C0205472 (UMLS CUI [2,2])
C1513916 (UMLS CUI [2,3])
Pregnancy | Breast Feeding | Pregnancy possible
Item
female participants who are pregnant, nursing, for may become pregnant;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0425965 (UMLS CUI [3])
Illness Unstable | Liver diseases | Kidney Diseases | Gastroenterology Disease | Respiration Disorders | Cardiovascular Diseases | Myocardial Ischemia | Endocrine System Diseases | Nervous system disorder | Craniocerebral Trauma Severe | Immune System Diseases | Hematological Disease
Item
any unstable medical illnesses including hepatic, renal, gastroenterologic, respiratory, cardiovascular (including ischemic heart disease); endocrinologic, neurologic (including history of severe head injury), immunologic, or hematologic disease;
boolean
C0221423 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0023895 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C0017163 (UMLS CUI [4,1])
C0012634 (UMLS CUI [4,2])
C0035204 (UMLS CUI [5])
C0007222 (UMLS CUI [6])
C0151744 (UMLS CUI [7])
C0014130 (UMLS CUI [8])
C0027765 (UMLS CUI [9])
C0018674 (UMLS CUI [10,1])
C0205082 (UMLS CUI [10,2])
C0021053 (UMLS CUI [11])
C0018939 (UMLS CUI [12])
Laboratory test result abnormal | Physical examination abnormal | Electrocardiogram abnormal
Item
clinically significant abnormalities of laboratories, physical examination, or ecg;
boolean
C0438215 (UMLS CUI [1])
C0747585 (UMLS CUI [2])
C0522055 (UMLS CUI [3])
At risk for suicide Serious
Item
participants judged to be at serious suicidal risk by the pi or another study-affiliated psychiatrist;
boolean
C0563664 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Medical contraindication MRI | Artificial cardiac pacemaker | Metallic foreign body Human body
Item
any contraindications to mri, including pacemakers or metallic objects in the body.
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0030163 (UMLS CUI [2])
C1720389 (UMLS CUI [3,1])
C1318419 (UMLS CUI [3,2])