Age
Item
1. age > 50 years
boolean
C0001779 (UMLS CUI [1])
Major Depressive Disorder | Major Depressive Disorder Recurrent
Item
2. major depressive disorder (mdd), single or recurrent, as diagnosed by the scid-iv (or scid-5 if available)
boolean
C1269683 (UMLS CUI [1])
C1269683 (UMLS CUI [2,1])
C2945760 (UMLS CUI [2,2])
Montgomery-Asberg Depression Rating Scale Questionnaire
Item
3. madrs > 15
boolean
C4054475 (UMLS CUI [1])
Relationship Clinical Primary Care Physician
Item
4. has or agrees to establish a clinical relationship with primary care physician (pcp).
boolean
C0439849 (UMLS CUI [1,1])
C0205210 (UMLS CUI [1,2])
C0033131 (UMLS CUI [1,3])
Availability of Informant | Availability of Emergency contact
Item
5. availability of an informant (e.g., emergency contact) is encouraged but not required for study participation
boolean
C0470187 (UMLS CUI [1,1])
C1550484 (UMLS CUI [1,2])
C0470187 (UMLS CUI [2,1])
C1552023 (UMLS CUI [2,2])
Informed Consent Unable
Item
1. inability to provide informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Depressive Symptoms Negligible MADRS
Item
2. depressive symptoms not severe enough (i.e., madrs < 15) at the baseline assessments
boolean
C0086132 (UMLS CUI [1,1])
C0332269 (UMLS CUI [1,2])
C4054475 (UMLS CUI [1,3])
Dementia
Item
3. dementia, as defined by 3ms < 80 and clinical evidence of dementia
boolean
C0497327 (UMLS CUI [1])
Bipolar I disorder Lifetime | Bipolar II disorder Lifetime | Schizophrenia Lifetime | Schizoaffective Disorder Lifetime | Schizophreniform Disorders Lifetime | Delusional disorder Lifetime | Psychotic symptom
Item
4. lifetime diagnosis of bipolar i or ii disorder, schizophrenia, schizoaffective disorder, schizophreniform disorder, delusional disorder, or current psychotic symptoms, as diagnosed by the scid
boolean
C0853193 (UMLS CUI [1,1])
C4071830 (UMLS CUI [1,2])
C0236788 (UMLS CUI [2,1])
C4071830 (UMLS CUI [2,2])
C0036341 (UMLS CUI [3,1])
C4071830 (UMLS CUI [3,2])
C0036337 (UMLS CUI [4,1])
C4071830 (UMLS CUI [4,2])
C0036358 (UMLS CUI [5,1])
C4071830 (UMLS CUI [5,2])
C0011251 (UMLS CUI [6,1])
C4071830 (UMLS CUI [6,2])
C0871189 (UMLS CUI [7])
Substance Use Disorders AUDIT-C | Substance Dependence AUDIT-C
Item
5. abuse of or dependence on alcohol or other substances within the past 3 months as determined by scid, and score of > 8 on audit-c and confirmed by study physician interview
boolean
C0038586 (UMLS CUI [1,1])
C3871151 (UMLS CUI [1,2])
C0038580 (UMLS CUI [2,1])
C3871151 (UMLS CUI [2,2])
High suicide risk | Suicidal intent | Planning suicide | Hospitalization Unwilling | Psychiatric referral Urgent
Item
6. high risk for suicide (e.g., active si and/or current/recent intent or plan) and unable to be managed safely in the clinical trial (e.g., unwilling to be hospitalized). urgent psychiatric referral will be made in these cases
boolean
C1271074 (UMLS CUI [1])
C0582496 (UMLS CUI [2])
C0424001 (UMLS CUI [3])
C0019993 (UMLS CUI [4,1])
C0558080 (UMLS CUI [4,2])
C0420390 (UMLS CUI [5,1])
C0439609 (UMLS CUI [5,2])
Medical contraindication Venlafaxine | Medical contraindication Buprenorphine | Intolerance to Venlafaxine U/day | Intolerance to Buprenorphine U/day
Item
7. contraindication to venlafaxine or buprenorphine as determined by pcp and study physician including history of intolerance of either venlafaxine or buprenorphine in the study target dosage range (venlafaxine at up to 300 mg/day; buprenorphine at up to 1.2 mg/day)
boolean
C1301624 (UMLS CUI [1,1])
C0078569 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0006405 (UMLS CUI [2,2])
C1744706 (UMLS CUI [3,1])
C0078569 (UMLS CUI [3,2])
C0456683 (UMLS CUI [3,3])
C1744706 (UMLS CUI [4,1])
C0006405 (UMLS CUI [4,2])
C0456683 (UMLS CUI [4,3])
Lacking Able to communicate English Language
Item
8. inability to communicate in english (i.e., interview cannot be conducted without an interpreter; subject largely unable to understand questions and cannot respond in english)
boolean
C0332268 (UMLS CUI [1,1])
C2364293 (UMLS CUI [1,2])
C0376245 (UMLS CUI [1,3])
Hypesthesia | Correction Unsuccessful
Item
9. non-correctable clinically significant sensory impairment (i.e., cannot hear well enough to cooperate with interview)
boolean
C0020580 (UMLS CUI [1])
C1947976 (UMLS CUI [2,1])
C1272705 (UMLS CUI [2,2])
Illness Unstable | Delirium | Diabetic - poor control | Hypertensive disease | Hyperlipidemia | Risk factors Cerebrovascular | Risk factor for cardiovascular disease
Item
10. unstable medical illness, including delirium, uncontrolled diabetes mellitus, hypertension, hyperlipidemia, or cerebrovascular or cardiovascular risk factors that are not under medical management. this will be determined based on information from the patient's personal physician and study physician's clinical judgment. referral to the patient's personal physician or to a general practitioner will be made in these cases
boolean
C0221423 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C0011206 (UMLS CUI [2])
C0421258 (UMLS CUI [3])
C0020538 (UMLS CUI [4])
C0020473 (UMLS CUI [5])
C0035648 (UMLS CUI [6,1])
C1880018 (UMLS CUI [6,2])
C0847284 (UMLS CUI [7])
Psychotropic Drugs | Exception Benzodiazepines Dose Stable | Exception Lorazepam Dose | Exception Hypnotics and Sedatives Dose Stable | Exception Zolpidem | Exception Zaleplon | Exception Eszopiclone | Exception Gabapentin Neuropathy
Item
11. subjects taking psychotropic medications that cannot be safely tapered and discontinued prior to study initiation. the following exceptions are allowed if they have been taken at a stable dose for at least 4 weeks prior to study entry and there is not a plan to change the dose during the next 32 -36 weeks: benzodiazepines up to 2 mg/d lorazepam equivalent; other sedative-hypnotics (e.g., zolpidem, zaleplon, eszopiclone); gabapentin if prescribed for non-psychiatric indication (e.g., neuropathy)
boolean
C0033978 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0005064 (UMLS CUI [2,2])
C0178602 (UMLS CUI [2,3])
C0205360 (UMLS CUI [2,4])
C1705847 (UMLS CUI [3,1])
C0024002 (UMLS CUI [3,2])
C0178602 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0020592 (UMLS CUI [4,2])
C0178602 (UMLS CUI [4,3])
C0205360 (UMLS CUI [4,4])
C1705847 (UMLS CUI [5,1])
C0078839 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0251504 (UMLS CUI [6,2])
C1705847 (UMLS CUI [7,1])
C1436328 (UMLS CUI [7,2])
C1705847 (UMLS CUI [8,1])
C0060926 (UMLS CUI [8,2])
C0442874 (UMLS CUI [8,3])
Opiate Abuse | Opiate Addiction
Item
12. history of opiate abuse or dependence
boolean
C0376196 (UMLS CUI [1,1])
C1546935 (UMLS CUI [1,2])
C0524662 (UMLS CUI [2])
Severe pain Numeric Rating Scale for Pain
Item
13. severe pain, defined as > 7 on 0-10 numeric rating scale for pain
boolean
C0278140 (UMLS CUI [1,1])
C1518471 (UMLS CUI [1,2])
CYP3A4 Inhibitor Strong | CYP3A4 Inhibitor Moderate | Indinavir | Nelfinavir | Ritonavir | Clarithromycin | Itraconazole | Ketoconazole | nefazodone | Saquinavir | telithromycin | aprepitant | Erythromycin | Fluconazole | GRAPEFRUIT JUICE | Verapamil | Diltiazem
Item
14. concomitant use of strong or moderate cyp3a4 inhibitor (indinavir, nelfinavir, ritonavir, clarithromycin, itraconazole, ketonazole, nefazodone, saquinovir, telithromycin, aprepitant, erythromycin, fluconazole, grapefruit juice, verapamil, diltiazem)
boolean
C3830624 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C3830624 (UMLS CUI [2,1])
C0205081 (UMLS CUI [2,2])
C0376637 (UMLS CUI [3])
C0525005 (UMLS CUI [4])
C0292818 (UMLS CUI [5])
C0055856 (UMLS CUI [6])
C0064113 (UMLS CUI [7])
C0022625 (UMLS CUI [8])
C0068485 (UMLS CUI [9])
C0286738 (UMLS CUI [10])
C0907410 (UMLS CUI [11])
C1176306 (UMLS CUI [12])
C0014806 (UMLS CUI [13])
C0016277 (UMLS CUI [14])
C0452456 (UMLS CUI [15])
C0042523 (UMLS CUI [16])
C0012373 (UMLS CUI [17])
Opioids Discontinue Refused
Item
15. refusal to stop all opioids (to avoid precipitating opioid withdrawal)
boolean
C0242402 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C1705116 (UMLS CUI [1,3])
Alcohol consumption Discontinue Refused
Item
16. refusal to discontinue all alcohol (to reduce the risk of respiratory depression)
boolean
C0001948 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C1705116 (UMLS CUI [1,3])
Hepatic impairment | Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
17. hepatic impairment (ast/alt > 1.5 times upper normal)
boolean
C0948807 (UMLS CUI [1])
C0151904 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
Estimated Glomerular Filtration Rate
Item
18. estimated glomerular filtration rate (gfr) < 20 ml/min
boolean
C3811844 (UMLS CUI [1])
Emergency contact Identification Unable | Emergency contact Identification Refused
Item
19. inability/refusal to identify a person as an emergency contact
boolean
C1552023 (UMLS CUI [1,1])
C0205396 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C1552023 (UMLS CUI [2,1])
C0205396 (UMLS CUI [2,2])
C1705116 (UMLS CUI [2,3])