Age | B-Cell Lymphoma indolent TNM clinical staging | MALT Lymphoma Grade | Follicular Lymphoma Grade | Mantle cell lymphoma | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Ineligible
Item
1. patients 18 years or older with stage i-iv indolent b cell lymphoma, including malt and follicular grade i/ii. patients with mantle cell lymphoma will also be included in this study, as mantle cell lymphoma is also radiosensitive, despite it not being an indolent b cell lymphoma. patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll) are ineligible
boolean
C0001779 (UMLS CUI [1])
C0079731 (UMLS CUI [2,1])
C0234227 (UMLS CUI [2,2])
C3258246 (UMLS CUI [2,3])
C0242647 (UMLS CUI [3,1])
C0441800 (UMLS CUI [3,2])
C0024301 (UMLS CUI [4,1])
C0441800 (UMLS CUI [4,2])
C0334634 (UMLS CUI [5])
C1302547 (UMLS CUI [6,1])
C1512714 (UMLS CUI [6,2])
Measurable Disease Orbital lymphoma | B-Cell Lymphoma Biopsy
Item
2. patients must have measurable disease within the orbit, either clinically or radiographically after biopsy confirmation of b cell lymphoma
boolean
C1513041 (UMLS CUI [1,1])
C0271333 (UMLS CUI [1,2])
C0079731 (UMLS CUI [2,1])
C0005558 (UMLS CUI [2,2])
Involvement with Ocular adnexa Bilateral | Unilateral disease Biopsy | Suspicion High Bilateral Disease
Item
3. bilateral ocular adnexal involvement is permitted, if biopsy confirms unilateral disease and there is high clinical suspicion for bilateral disease, biopsy of the contralateral ocular adnexa can be waived.
boolean
C1314939 (UMLS CUI [1,1])
C0229243 (UMLS CUI [1,2])
C0238767 (UMLS CUI [1,3])
C4035394 (UMLS CUI [2,1])
C0005558 (UMLS CUI [2,2])
C0242114 (UMLS CUI [3,1])
C0205250 (UMLS CUI [3,2])
C1511113 (UMLS CUI [3,3])
Childbearing Potential Serum pregnancy test (B-HCG) Negative
Item
4. female patients of childbearing potential must have a negative serum pregnancy test (beta-hcg) within 2 weeks of protocol entry.
boolean
C3831118 (UMLS CUI [1,1])
C0430060 (UMLS CUI [1,2])
C1513916 (UMLS CUI [1,3])
Systemic therapy Planned | Status post Irradiation of orbit
Item
5. planned systemic therapy after orbital radiation therapy is permitted however the timing of systemic therapy will be recorded and patients will be stratified according to receipt of adjuvant systemic therapy.
boolean
C1515119 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C0231290 (UMLS CUI [2,1])
C2148573 (UMLS CUI [2,2])
Gender Barrier Contraception | Gender Sexual Abstinence Heterosexual
Item
6. male patients must agree to use a barrier method of contraception or agree to abstain from heterosexual activity for the duration of the study
boolean
C0079399 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2,1])
C0036899 (UMLS CUI [2,2])
C0019421 (UMLS CUI [2,3])
Gender Barrier Contraception Double | Gender Sexual Abstinence Heterosexual | Postmenopausal state | Female Sterilization
Item
7. female patients must be willing to use two adequate barrier methods of contraception to prevent pregnancy or agree to abstain from heterosexual activity throughout the study or be post-menopausal (free from menses > two years or surgically sterilized).
boolean
C0079399 (UMLS CUI [1,1])
C0004764 (UMLS CUI [1,2])
C0205173 (UMLS CUI [1,3])
C0079399 (UMLS CUI [2,1])
C0036899 (UMLS CUI [2,2])
C0019421 (UMLS CUI [2,3])
C0232970 (UMLS CUI [3])
C0015787 (UMLS CUI [4])
Informed Consent
Item
8. patients must have the ability to give informed consent.
boolean
C0021430 (UMLS CUI [1])
Chemotherapy | Rituxan
Item
1. patients treated with chemotherapy within 4 weeks of protocol enrollment (including rituxan).
boolean
C0392920 (UMLS CUI [1])
C0732355 (UMLS CUI [2])
B-Cell Lymphomas | Diffuse Large B-Cell Lymphoma | Follicular Lymphoma Grade
Item
2. patients with aggressive b cell lymphoma histology, including diffuse large b cell lymphoma (dlbcl) and grade 3 follicular lymphoma.
boolean
C0079731 (UMLS CUI [1])
C0079744 (UMLS CUI [2])
C0024301 (UMLS CUI [3,1])
C0441800 (UMLS CUI [3,2])
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Item
3. patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (cll/sll)
boolean
C1302547 (UMLS CUI [1])
Irradiation of orbit Previous
Item
4. patients with a history of prior radiation to the orbit if re-treatment would exceed known orbital tolerance
boolean
C2148573 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
Retinal Disease Pre-existing
Item
5. patients with pre-existing retinopathy
boolean
C0035309 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
Pregnancy
Item
6. patients who are pregnant
boolean
C0032961 (UMLS CUI [1])
Lupus Erythematosus | Scleroderma
Item
7. patients with active lupus or scleroderma are ineligible
boolean
C0409974 (UMLS CUI [1])
C0011644 (UMLS CUI [2])