Age
Item
patients between 18 and 75 years of age.
boolean
C0001779 (UMLS CUI [1])
Non-squamous non-small cell lung cancer TNM clinical staging | Curative treatment Unsuccessful | Operative Surgical Procedures Unsuccessful | Therapeutic radiology procedure Unsuccessful
Item
present with histologically proven or cytological diagnosis of non-squamous nsclc stage iiib or iv as defined by the american joint committee on cancer staging criteria for lung cancer, that is not amenable to curative therapy,such as surgery or radiotherapy and so on.
boolean
C4324656 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C1273390 (UMLS CUI [2,1])
C1272705 (UMLS CUI [2,2])
C0543467 (UMLS CUI [3,1])
C1272705 (UMLS CUI [3,2])
C1522449 (UMLS CUI [4,1])
C1272705 (UMLS CUI [4,2])
Systemic Chemotherapy Absent Carcinoma of lung | Targeted Therapy Absent Carcinoma of lung
Item
no prior systemic chemotherapy or targeted therapy for lung cancer before screening.
boolean
C1883256 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0684249 (UMLS CUI [1,3])
C2985566 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0684249 (UMLS CUI [2,3])
EGFR Activating Mutation | EGFR exon 19 deletion | Point mutation in exon 21 (L858R)
Item
confirmed activating mutation of egfr—ie, an exon 19 deletion or an exon 21 l858r point mutation.
boolean
C2984891 (UMLS CUI [1])
C3889117 (UMLS CUI [2])
C3888903 (UMLS CUI [3])
ECOG performance status
Item
eastern cooperative oncology group(ecog) performance status of 0 or 1.
boolean
C1520224 (UMLS CUI [1])
Organ function
Item
adequate organ function.
boolean
C0678852 (UMLS CUI [1])
Prior radiation therapy Bone Marrow Percentage | Prior radiation therapy Absent Whole-Pelvis | Prior radiation therapy Completed | Toxicity Due to Prior radiation therapy | Patient recovered
Item
prior radiation therapy allowed to <25% of the bone marrow . prior radiation to the whole pelvis is not allowed. prior radiotherapy must be completed at least 4 weeks before study enrollment. patients must have recovered from the acute toxic effects of the treatment prior to study enrollment.
boolean
C0279134 (UMLS CUI [1,1])
C0005953 (UMLS CUI [1,2])
C0439165 (UMLS CUI [1,3])
C0279134 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C3827467 (UMLS CUI [2,3])
C0279134 (UMLS CUI [3,1])
C0205197 (UMLS CUI [3,2])
C0600688 (UMLS CUI [4,1])
C0678226 (UMLS CUI [4,2])
C0279134 (UMLS CUI [4,3])
C1115804 (UMLS CUI [5])
Informed Consent
Item
signed informed consent document on file.
boolean
C0021430 (UMLS CUI [1])
Life Expectancy
Item
estimated life expectancy of ≥12 weeks.
boolean
C0023671 (UMLS CUI [1])
Compliance behavior Follow-up | Geographic Location allowing Follow-up
Item
patient compliance and geographic proximity that allow adequate follow up.
boolean
C1321605 (UMLS CUI [1,1])
C3274571 (UMLS CUI [1,2])
C0017446 (UMLS CUI [2,1])
C0683607 (UMLS CUI [2,2])
C3274571 (UMLS CUI [2,3])
Severe allergy Erlotinib
Item
known severe hypersensitivity to erlotinib.
boolean
C2945656 (UMLS CUI [1,1])
C1135135 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain Uncontrolled
Item
patients with uncontrolled brain metastasis.
boolean
C0220650 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Drainage Unsuccessful Pleural effusion | Drainage Unsuccessful Cardiac effusion | Procedures Other Unsuccessful
Item
pleural effusion or pericardiac effusion that cannot be controlled by drainage or other procedures.
boolean
C0013103 (UMLS CUI [1,1])
C1272705 (UMLS CUI [1,2])
C0032227 (UMLS CUI [1,3])
C0013103 (UMLS CUI [2,1])
C1272705 (UMLS CUI [2,2])
C1399211 (UMLS CUI [2,3])
C0184661 (UMLS CUI [3,1])
C0205394 (UMLS CUI [3,2])
C1272705 (UMLS CUI [3,3])
Protocol Compliance Unable
Item
inability to comply with protocol or study procedures.
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
Comorbidity Systemic Serious | Completion of clinical trial At risk
Item
a serious concomitant systemic disorder that, in the opinion of the investigator, would compromise the patient's ability to complete the study.
boolean
C0009488 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C2732579 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
Condition Cardiac Serious | Myocardial Infarction | Angina Pectoris | Heart Disease
Item
a serious cardiac condition, such as myocardial infarction within 6 months, angina, or heart disease.
boolean
C0348080 (UMLS CUI [1,1])
C0018787 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0027051 (UMLS CUI [2])
C0002962 (UMLS CUI [3])
C0018799 (UMLS CUI [4])
Second Primary Cancer
Item
second primary malignancy that is clinically detectable at the time of consideration for study enrollment.
boolean
C0751623 (UMLS CUI [1])
Pneumonia, Interstitial
Item
interstitial pneumonia.
boolean
C0206061 (UMLS CUI [1])