Adenocarcinoma of large intestine | Colorectal Carcinoma TNM clinical staging | Secondary malignant neoplasm of liver unresectable | Lesion of liver metastatic measurable Quantity
Item
histological documentation of colorectal adenocarcinoma crc stage iv with predominant unresectable liver metastases and at least one measurable metastatic liver lesion
boolean
C1319315 (UMLS CUI [1])
C0009402 (UMLS CUI [2,1])
C3258246 (UMLS CUI [2,2])
C0494165 (UMLS CUI [3,1])
C1519810 (UMLS CUI [3,2])
C0577053 (UMLS CUI [4,1])
C1522484 (UMLS CUI [4,2])
C1513040 (UMLS CUI [4,3])
C1265611 (UMLS CUI [4,4])
WHO performance status scale
Item
performance status who criteria of < 2.
boolean
C1298650 (UMLS CUI [1])
Laboratory Results | Absolute neutrophil count | Platelet Count measurement | Lymphocyte Count measurement | Creatinine measurement, serum | Creatinine clearance measurement | Serum total bilirubin measurement
Item
laboratory values: absolute neutrophil count (anc) count > 1500 /mm³, platelet count > 100 000 /mm³, lymphocytes > 800 /mm³, serum creatinine < 2.0 mg/dl or creatinine clearance >40 ml/min, serum bilirubin < 2.0 mg/dl
boolean
C1254595 (UMLS CUI [1])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0200635 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
C0373595 (UMLS CUI [6])
C1278039 (UMLS CUI [7])
Progressive Disease | Status post Systemic Chemotherapy Palliative
Item
progressive disease following standard of care palliative systemic chemotherapy
boolean
C1335499 (UMLS CUI [1])
C0231290 (UMLS CUI [2,1])
C1883256 (UMLS CUI [2,2])
C1285530 (UMLS CUI [2,3])
Informed Consent
Item
able to give written informed consent.
boolean
C0021430 (UMLS CUI [1])
Prior radiation therapy Lesion of liver
Item
no prior radiotherapy to all target liver lesions
boolean
C0279134 (UMLS CUI [1,1])
C0577053 (UMLS CUI [1,2])
Operation on stomach | Operative Surgical Procedures Hepatobiliary System | Exception Cholecystectomy Simple | Liver disease Concurrent | Disease Serious | Other medical condition Serious
Item
no previous history of gastric or hepatobiliary surgery (except for simple cholecystectomy, no concurrent liver disease or other serious medical disease or condition
boolean
C0192398 (UMLS CUI [1])
C0543467 (UMLS CUI [2,1])
C1711359 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0008320 (UMLS CUI [3,2])
C0205352 (UMLS CUI [3,3])
C0023895 (UMLS CUI [4,1])
C0205420 (UMLS CUI [4,2])
C0012634 (UMLS CUI [5,1])
C0205404 (UMLS CUI [5,2])
C3843040 (UMLS CUI [6,1])
C0205404 (UMLS CUI [6,2])
Investigational New Drugs
Item
no concomitant use of other investigational drugs.
boolean
C0013230 (UMLS CUI [1])
Neuropathy Pre-existing Toxicity Grade
Item
no pre-existing neuropathy with a severity of > grade 1 in the who toxicity scale.
boolean
C0442874 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C0600688 (UMLS CUI [1,3])
C0441800 (UMLS CUI [1,4])
Malignant Neoplasms | Exception Carcinoma in situ of uterine cervix Treated | Exception Basal cell carcinoma Treated | Exception Squamous cell carcinoma of skin Treated | Exception Curative treatment Cancer Other
Item
no previous or concurrent malignancies except for adequately treated in situ carcinoma of the cervix uteri, basal or squamous cell carcinoma of the skin or any other malignancy given potentially curative treatment more than 5 years before study entry
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0851140 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0007117 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0553723 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C1273390 (UMLS CUI [5,2])
C1707251 (UMLS CUI [5,3])
Pregnancy | Breast Feeding | At risk of unplanned pregnancy Contraceptive methods
Item
no pregnant or breast-feeding female patients, use of an effective contraceptive if the risk of conception exists during study treatment.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3839721 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
Colorectal Carcinoma Metastasis | Excision Curative intent
Item
no candidate for the resection of all crc metastases with curative intent.
boolean
C0009402 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
C0728940 (UMLS CUI [2,1])
C1276305 (UMLS CUI [2,2])