Adult B Acute Lymphoblastic Leukemia Recurrent | Adult B Acute Lymphoblastic Leukemia Refractory | Chronic Lymphocytic Leukemia | Lymphoma, Non-Hodgkin
Item
1. relapsed or refractory b cell derived acute lymphoblastic leukemia(all), chronic lymphoblastic leukemia(cll) and non-hodgkin lymphoma.
boolean
C0279593 (UMLS CUI [1,1])
C2945760 (UMLS CUI [1,2])
C0279593 (UMLS CUI [2,1])
C0205269 (UMLS CUI [2,2])
C0023434 (UMLS CUI [3])
C0024305 (UMLS CUI [4])
Karnofsky Performance Status
Item
2. kps>60.
boolean
C0206065 (UMLS CUI [1])
Life Expectancy
Item
3. life expectancy>3 months.
boolean
C0023671 (UMLS CUI [1])
Age
Item
4. gender unlimited, age from 18 years to 70 years.
boolean
C0001779 (UMLS CUI [1])
Disease Progression
Item
5. disease progresses but reserves reaction to recent treatments.
boolean
C0242656 (UMLS CUI [1])
Standard therapy Quantity failed
Item
6. patients who have failed at least one line of a standard treatment.
boolean
C2936643 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0231175 (UMLS CUI [1,3])
Absence Mental disorders Serious
Item
7. no serious mental disorder.
boolean
C0332197 (UMLS CUI [1,1])
C0004936 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
Cardiac function | Heart Disease Absent | Left ventricular ejection fraction | Pulmonary function | Oxygen saturation measurement on room air | Renal function | Creatinine measurement, serum
Item
8. patients must have adequate cardiac function(no cardiac disease, lvef≥40% ), adequate pulmonary function as indicated by room air oxygen saturation of >94%, and adequate renal function(cr≤133umol/l).
boolean
C0232164 (UMLS CUI [1])
C0018799 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0428772 (UMLS CUI [3])
C0231921 (UMLS CUI [4])
C0523807 (UMLS CUI [5,1])
C2709070 (UMLS CUI [5,2])
C0232804 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
Absence Disease Serious | Autoimmune Disease Absent | Immunodeficiency Absent
Item
9. no other serious diseases(autoimmune disease, immunodeficiency etc.).
boolean
C0332197 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0205404 (UMLS CUI [1,3])
C0004364 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0021051 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Cancer Other Absent
Item
10. no other tumors.
boolean
C1707251 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Participates as a volunteer Research
Item
11. patients volunteer to participate in the research.
boolean
C1821911 (UMLS CUI [1,1])
C0035168 (UMLS CUI [1,2])
Karnofsky Performance Status
Item
1. kps<50.
boolean
C0206065 (UMLS CUI [1])
Hypersensitivity Cytokine
Item
2. patients are allergic to cytokines.
boolean
C0020517 (UMLS CUI [1,1])
C0079189 (UMLS CUI [1,2])
Central nervous system leukaemia
Item
3. central nervous system leukemia within 28 days.
boolean
C1332884 (UMLS CUI [1])
Communicable Disease Uncontrolled
Item
4. uncontrolled active infection.
boolean
C0009450 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Graft-vs-Host Disease | Chronic graft-versus-host disease
Item
5. acute or chronic gvhd.
boolean
C0018133 (UMLS CUI [1])
C0867389 (UMLS CUI [2])
T cell Inhibitors
Item
6. treated with t cell inhibitor.
boolean
C0039194 (UMLS CUI [1,1])
C0243077 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
7. pregnancy and nursing females.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
HIV Infection
Item
8. hiv affected.
boolean
C0019693 (UMLS CUI [1])
Social situation Inappropriate Research
Item
9. other situations we think improper for the research.
boolean
C0748872 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0035168 (UMLS CUI [1,3])