Parkinson Disease | Age
Item
idiopathic parkinson's disease (pd) diagnosed between the ages of 30 and 80 years;
boolean
C0030567 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
MDS-UPDRS - Hoehn and Yahr Stage
Item
hoehn and yahr stage 1-3 in an "on" state;
boolean
C3639483 (UMLS CUI [1])
Pharmacotherapy Containing Levodopa | Requirement Pharmaceutical Preparation times/day
Item
require levodopa-containing medication regimen at least 4 times during the waking day;
boolean
C0013216 (UMLS CUI [1,1])
C0332256 (UMLS CUI [1,2])
C0023570 (UMLS CUI [1,3])
C1514873 (UMLS CUI [2,1])
C0013227 (UMLS CUI [2,2])
C0439511 (UMLS CUI [2,3])
Motor fluctuations hours/day Minimum | Levodopa | Disease Response
Item
experience motor fluctuations with a minimum of 2 hours of average daily "off" time per waking day (excluding early morning "off" time) and demonstrate levodopa responsiveness;
boolean
C1868976 (UMLS CUI [1,1])
C0556974 (UMLS CUI [1,2])
C1524031 (UMLS CUI [1,3])
C0023570 (UMLS CUI [2])
C1704632 (UMLS CUI [3])
Antiparkinson Agents Stable
Item
are on stable pd medication regimen;
boolean
C0003405 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
Levodopa Dose U/day
Item
total daily ld dose <1600 mg/day;
boolean
C0023570 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
Ability Perform Spirometry
Item
able to perform a spirometry maneuver in the on and off states
boolean
C0085732 (UMLS CUI [1,1])
C0884358 (UMLS CUI [1,2])
C0037981 (UMLS CUI [1,3])
Normal cognition Mini-mental state examination
Item
normal cognition confirmed by mmse score ≥25 ;
boolean
C2712133 (UMLS CUI [1,1])
C0451306 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
pregnant or lactating females;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Operative Surgical Procedures Parkinson Disease | Stereotactic surgery Planned
Item
previous surgery for pd or plan to have stereotactic surgery during the study period;
boolean
C0543467 (UMLS CUI [1,1])
C0030567 (UMLS CUI [1,2])
C1735594 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
Psychotic symptom Treatment required for | Feeling suicidal | Suicide attempt
Item
history of psychotic symptoms requiring treatment, or suicide ideation or attempt within last year;
boolean
C0871189 (UMLS CUI [1,1])
C0332121 (UMLS CUI [1,2])
C0424000 (UMLS CUI [2])
C0038663 (UMLS CUI [3])
Medical contraindication Levodopa
Item
known contraindication to the use of levodopa;
boolean
C1301624 (UMLS CUI [1,1])
C0023570 (UMLS CUI [1,2])
Condition Study Subject Participation Status Inappropriate | Comorbidity Severe Study Subject Participation Status Inappropriate | Abnormality Study Subject Participation Status Inappropriate | Finding Study Subject Participation Status Inappropriate | Condition compromises Patient safety | Comorbidity Severe compromises Patient safety | Abnormality compromises Patient safety | Finding compromises Patient safety
Item
any significant condition, severe concurrent disease, abnormality or finding that would make patients unsuitable or may compromise patient safety;
boolean
C0348080 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C1548788 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
C1548788 (UMLS CUI [2,4])
C1704258 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C1548788 (UMLS CUI [3,3])
C0243095 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C1548788 (UMLS CUI [4,3])
C0348080 (UMLS CUI [5,1])
C2945640 (UMLS CUI [5,2])
C1113679 (UMLS CUI [5,3])
C0009488 (UMLS CUI [6,1])
C0205082 (UMLS CUI [6,2])
C2945640 (UMLS CUI [6,3])
C1113679 (UMLS CUI [6,4])
C1704258 (UMLS CUI [7,1])
C2945640 (UMLS CUI [7,2])
C1113679 (UMLS CUI [7,3])
C0243095 (UMLS CUI [8,1])
C2945640 (UMLS CUI [8,2])
C1113679 (UMLS CUI [8,3])
Medical contraindication Routine Spirometry
Item
any any contraindication to performing routine spirometry.
boolean
C1301624 (UMLS CUI [1,1])
C0205547 (UMLS CUI [1,2])
C0037981 (UMLS CUI [1,3])