Age and consent
Item
Written consent from female or male japanese patients aged 20 years and over.
boolean
C0001779 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
C1556094 (UMLS CUI [3])
Diagnosis
Item
Patient with previous diagnosis of unresectable, locally advanced or metastatic, hereditary or sporadic medullary thyroid carcinoma(mtc).
boolean
C1833921 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
C0677984 (UMLS CUI [1,3])
C1710166 (UMLS CUI [2,1])
C1519810 (UMLS CUI [2,2])
C0677984 (UMLS CUI [2,3])
C1833921 (UMLS CUI [3,1])
C1519810 (UMLS CUI [3,2])
C0027627 (UMLS CUI [3,3])
C1710166 (UMLS CUI [4,1])
C1519810 (UMLS CUI [4,2])
C0027627 (UMLS CUI [4,3])
Overall health status
Item
Patient who has a good overall health status(world health organization (who) performance status 0-2).
boolean
C0018759 (UMLS CUI [1,1])
C1298650 (UMLS CUI [1,2])
Renal function
Item
Patient who has appropriate renal conditions confirmed by test results for taking part in the study.
boolean
C0232804 (UMLS CUI [1,1])
C1548787 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
Disease
Item
Patient with measurable disease (at least one lesion, not irradiated within 12 weeks of study registration, with longest diameter more or equal 10mm (lymph nodes minimum more or equal 15 mm) with ct or mri).
boolean
C1513041 (UMLS CUI [1])
C3846110 (UMLS CUI [2])
C0221198 (UMLS CUI [3,1])
C1301886 (UMLS CUI [3,2])
Pregnancy
Item
Patient with evidence of non-childbearing status or postmenopausal status.
text
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0232970 (UMLS CUI [2])
Brain metastases
Item
Patient with brain metastases or spinal cord compression.
boolean
C0220650 (UMLS CUI [1])
C0037926 (UMLS CUI [2])
Comorbidities
Item
Patient with significant abnormal ecg (qtcb correction unmeasurable or more than 480 ms) findings and /or significant cardiac conditions or events, uncontrolled hypertension and evidence of severe lung disease.
boolean
C0438154 (UMLS CUI [1,1])
C0205161 (UMLS CUI [1,2])
C3828433 (UMLS CUI [2])
C1882512 (UMLS CUI [3,1])
C1518373 (UMLS CUI [3,2])
C0018799 (UMLS CUI [4])
C0741923 (UMLS CUI [5])
C1868885 (UMLS CUI [6])
C0024115 (UMLS CUI [7,1])
C0205082 (UMLS CUI [7,2])
Electrolytes and organ function
Item
Patient with abnormal electrolytes such as potassium, magnesium and calcium, or abnormal organ functions such as decreased creatinine clearance.
boolean
C0032821 (UMLS CUI [1,1])
C0205161 (UMLS CUI [1,2])
C0373675 (UMLS CUI [2,1])
C0205161 (UMLS CUI [2,2])
C0201925 (UMLS CUI [3,1])
C0205161 (UMLS CUI [3,2])
C0151577 (UMLS CUI [4])
C1254358 (UMLS CUI [5,1])
C0205161 (UMLS CUI [5,2])
C0151613 (UMLS CUI [6])
Abnormal laboratory findings
Item
Patient with significant abnormal laboratory findings (to include abnormal liver function tests (bilirubin more than 1.5xulrr, and alt, ast, or alp more than 2.5xulrr or 5.0xulrr if related to liver metastases).
boolean
C0438215 (UMLS CUI [1])
C3888966 (UMLS CUI [2])
C0311468 (UMLS CUI [3])
C0151905 (UMLS CUI [4])
C0151849 (UMLS CUI [5])
Prior treatment
Item
Prior treatment received within 28 days before registration.
boolean
C1514463 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])