Smoker
Item
Patient is a cigarette smoker (smokes ≥ 10 cigarettes per day)
boolean
C0543414 (UMLS CUI [1])
Non-treatment seeking
Item
Non-treatment seeking (i.e., not trying to quit as indicated by <7 on the contemplation ladder)
boolean
C0679860 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
Age
Item
Patient aged 18-55
boolean
C0001779 (UMLS CUI [1])
IQ
Item
Patient has an intelligence quotient (iq) ≥80 on the wechsler test of adult reading [89]
boolean
C0456149 (UMLS CUI [1,1])
C4505449 (UMLS CUI [1,2])
Nicotine dependency
Item
Patient with fagerstrom test of nicotine dependence (ftnd) ≥4 [90]
boolean
C0028043 (UMLS CUI [1,1])
C0451156 (UMLS CUI [1,2])
Medical condition of patient
Item
Patient must meet structured clinical interview for the diagnostic and statistical manual for mental disorders (scid-iv) diagnosis criteria for schizophrenia or schizoaffective disorder; be in stable remission from positive symptoms of psychosis as judged by a positive and negative syndrome scale (panss) positive score total score <70, and receiving a stable dose of antipsychotics for >1month.
boolean
C0011900 (UMLS CUI [1,1])
C1537054 (UMLS CUI [1,2])
C0036341 (UMLS CUI [1,3])
C0011900 (UMLS CUI [2,1])
C1537054 (UMLS CUI [2,2])
C0036337 (UMLS CUI [2,3])
C0544452 (UMLS CUI [3,1])
C0205360 (UMLS CUI [3,2])
C4086747 (UMLS CUI [3,3])
C1319421 (UMLS CUI [4])
Medical condition of control participant
Item
Control participant will not be taking any psychotropic medications at the time of enrollment and will not meet diagnostic criteria for any Axis I disorder, except past history of major depression or an anxiety disorder if in remission for at least one year.
boolean
C3532643 (UMLS CUI [1])
C0236870 (UMLS CUI [2])
C0332300 (UMLS CUI [3,1])
C0270461 (UMLS CUI [3,2])
C0439234 (UMLS CUI [3,3])
C0332300 (UMLS CUI [4,1])
C0003469 (UMLS CUI [4,2])
C0544452 (UMLS CUI [4,3])
C0439234 (UMLS CUI [4,4])
Substance use
Item
Patient with substance use (except nicotine or caffeine) in the last month
boolean
C0237123 (UMLS CUI [1])
C0332300 (UMLS CUI [2,1])
C0543414 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
C0332300 (UMLS CUI [3,1])
C0006644 (UMLS CUI [3,2])
C0332185 (UMLS CUI [3,3])
Alcohol/drug abuse history
Item
Patient with a history of alcohol/drug abuse in the 3 months before study enrollment
boolean
C0038586 (UMLS CUI [1,1])
C0332152 (UMLS CUI [1,2])
C4041024 (UMLS CUI [1,3])
Use of opioids
Item
Patient uses opioids (meperidine, oxycodone, methadone, etc)
boolean
C0240602 (UMLS CUI [1])
C0025376 (UMLS CUI [2])
C0030049 (UMLS CUI [3])
C0025605 (UMLS CUI [4])
Use of smoking cessation aids
Item
Patient currently uses smoking cessation aids (e.g., nicotine replacement therapy, bupropion or varenicline)
boolean
C1524063 (UMLS CUI [1,1])
C0085134 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
C1278444 (UMLS CUI [2])
C0085208 (UMLS CUI [3])
C4304585 (UMLS CUI [4])
Pregnancy or nursing
Item
Patient is pregnant or breastfeeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Contraindications to varenicline
Item
Patient with a history of renal insufficiency or a hypersensitivity to varenicline (champix®)
boolean
C0262926 (UMLS CUI [1,1])
C1565489 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C1569608 (UMLS CUI [2,2])
Neurological illess
Item
Patient with a history of neurological illness like epilepsy or medical condition known to significantly influence neurocognitive function
boolean
C2186518 (UMLS CUI [1])
C0014544 (UMLS CUI [2])
C0012634 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C0518895 (UMLS CUI [3,3])
C0542341 (UMLS CUI [3,4])
Medical condition
Item
any other medical condition deemed relevant by the qualified investigator.
boolean
C3843040 (UMLS CUI [1])