Neoplasm Metastasis Extrahepatic Absent Imaging | Liver carcinoma Multiple lesions | Lesion Diameter | Portal vein Tumor thrombus | Hepatic vein Tumor thrombus | Arteriovenous fistula | Tumor Cell Invasion Organs Adjacent | Exception Gallbladder | Liver carcinoma Diffuse
Item
no extrahepatic spread on imaging, and filfill one of them as follows: 1.multiple hcc lesions,＞ 5.0 cm in diameter;2.portal venous hepatic vein/tumor thrombus or arteriovenous/portal fistula;3.direct invasion adjacent organs except gallbladder or penetrate the peritoneum;4.diffuse hcc.
boolean
C0027627 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C0011923 (UMLS CUI [1,4])
C2239176 (UMLS CUI [2,1])
C0577305 (UMLS CUI [2,2])
C0221198 (UMLS CUI [3,1])
C1301886 (UMLS CUI [3,2])
C1305775 (UMLS CUI [4,1])
C3163918 (UMLS CUI [4,2])
C0019155 (UMLS CUI [5,1])
C3163918 (UMLS CUI [5,2])
C0003855 (UMLS CUI [6])
C1269955 (UMLS CUI [7,1])
C0178784 (UMLS CUI [7,2])
C0205117 (UMLS CUI [7,3])
C1705847 (UMLS CUI [8,1])
C0016976 (UMLS CUI [8,2])
C2239176 (UMLS CUI [9,1])
C0205219 (UMLS CUI [9,2])
ECOG performance status
Item
eastern cooperative oncology group performance status 0-2
boolean
C1520224 (UMLS CUI [1])
Child-Pugh Classification
Item
child-pugh stage a or b
boolean
C2347612 (UMLS CUI [1])
Target Lesion intrahepatic Evaluable Quantity
Item
at least one evaluable intrahepatic target lesions
boolean
C2986546 (UMLS CUI [1,1])
C1512948 (UMLS CUI [1,2])
C1516986 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
Sorafenib | Sorafenib Discontinued | Disease Progression | Intolerance to Sorafenib | Sorafenib Refused
Item
previous accept sorafenib but stoped for more than 4 weeks because of disease progression or intolerance to sorafenib or refused to recieved sorafenib
boolean
C1516119 (UMLS CUI [1])
C1516119 (UMLS CUI [2,1])
C1444662 (UMLS CUI [2,2])
C0242656 (UMLS CUI [3])
C1744706 (UMLS CUI [4,1])
C1516119 (UMLS CUI [4,2])
C1516119 (UMLS CUI [5,1])
C1705116 (UMLS CUI [5,2])
Local Therapy Tumor | Excision | Radiofrequency ablation | Transarterial Chemoembolization
Item
stoped for more than 4 weeks after local treatments(surgical resection, radiofrequency ablation, transcatheter arterial chemoembolization) of tumor if presence
boolean
C1517925 (UMLS CUI [1,1])
C0027651 (UMLS CUI [1,2])
C0728940 (UMLS CUI [2])
C0850292 (UMLS CUI [3])
C3539919 (UMLS CUI [4])
Informed Consent
Item
sign the informed consent.
boolean
C0021430 (UMLS CUI [1])
oxaliplatin | Fluorouracil | Leucovorin
Item
ever received oxaliplatin or fluorouracil/leucovorin;
boolean
C0069717 (UMLS CUI [1])
C0016360 (UMLS CUI [2])
C0023413 (UMLS CUI [3])
Platelet Count measurement | Prothrombin time assay
Item
a platelet counts of > 60,000/mm3, prothrombin time activity ＜40%;
boolean
C0032181 (UMLS CUI [1])
C0033707 (UMLS CUI [2])
Albumin measurement | Serum total bilirubin measurement | Alanine aminotransferase increased | Aspartate aminotransferase increased
Item
albumin ＜2.8 g/dl, total bilirubin ≥51.3 umol/l; alanine aminotransferase (alt) and aspartate transaminase（ast）≥5 times of upper limit
boolean
C0201838 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0151905 (UMLS CUI [3])
C0151904 (UMLS CUI [4])
Ascites Uncontrolled | Refractory Ascites | Bleeding varices | Encephalopathy
Item
uncontrolled or refractory ascites, ongoing variceal bleeding or encephalopathy;
boolean
C0003962 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0205269 (UMLS CUI [2,1])
C0003962 (UMLS CUI [2,2])
C0333106 (UMLS CUI [3])
C0085584 (UMLS CUI [4])
Heart Diseases Severe | Brain Diseases Severe | Kidney Diseases Severe
Item
severe heart, brain or kidney diseases
boolean
C0018799 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0006111 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0022658 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
Cancer Other | Primary tumor site Different Liver carcinoma | Histology Different Liver carcinoma
Item
previous or concurrent cancer that is distinct in primary site or histology from hcc
boolean
C1707251 (UMLS CUI [1])
C0475447 (UMLS CUI [2,1])
C1705242 (UMLS CUI [2,2])
C2239176 (UMLS CUI [2,3])
C4048239 (UMLS CUI [3,1])
C1705242 (UMLS CUI [3,2])
C2239176 (UMLS CUI [3,3])
Pregnancy | Breast Feeding
Item
pregnant women or lactating women;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Fluorouracil allergy | Hypersensitivity Oxaliplatin | Hypersensitivity Leucovorin Calcium | Iodine contrast allergy
Item
allergy to fluorouracil, oxaliplatin, leucovorin calcium or iodine contrast agent.
boolean
C0570698 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0069717 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0731033 (UMLS CUI [3,2])
C4022917 (UMLS CUI [4])