Liver carcinoma | Nodule of liver High risk | Alpha one fetoprotein measurement | Liver carcinoma Patterns Quantity CT scan contrast | Liver carcinoma Patterns Quantity MRI with contrast | Liver carcinoma Patterns Quantity Angiography | Nodule size Liver Cirrhosis
Item
1. patients must have a diagnosis of hcc by at least one criterion listed below (korean liver cancer study group (klcsg) guideline 2009) 1.1 pathologically (histologically or cytologically) proven diagnosis of hcc 1.2 liver nodule in high risk group 1.2.1 if alpha fetoprotein (afp) ≥200 ng/ml , ≥ 1 typical hcc enhancing pattern on dynamic contrast enhanced ct or mri 1.2.2 if afp<200 ng/ml, ≥2 typical hcc enhancing pattern on dynamic contrast enhanced ct, mri, and angiography 1.3 ≥ 2 cm nodule in liver cirrhosis (lc), ≥ 1 typical hcc enhancing pattern on dynamic contrast enhanced ct or mri
boolean
C2239176 (UMLS CUI [1])
C0745761 (UMLS CUI [2,1])
C4319571 (UMLS CUI [2,2])
C0201539 (UMLS CUI [3])
C2239176 (UMLS CUI [4,1])
C0449774 (UMLS CUI [4,2])
C1265611 (UMLS CUI [4,3])
C0742919 (UMLS CUI [4,4])
C2239176 (UMLS CUI [5,1])
C0449774 (UMLS CUI [5,2])
C1265611 (UMLS CUI [5,3])
C0202671 (UMLS CUI [5,4])
C2239176 (UMLS CUI [6,1])
C0449774 (UMLS CUI [6,2])
C1265611 (UMLS CUI [6,3])
C0002978 (UMLS CUI [6,4])
C0449457 (UMLS CUI [7,1])
C0023890 (UMLS CUI [7,2])
Portal vein Tumor thrombus | Enhancement Arterial CT Multiphasic | Enhancement Arterial MRI Multiphasic | Washout CT Multiphasic | Washout MRI Multiphasic
Item
2. patients must have a diagnosis of pvtt 2.1 early arterial enhancement and delayed washout on multiphasic ct or mri
boolean
C1305775 (UMLS CUI [1,1])
C3163918 (UMLS CUI [1,2])
C2349975 (UMLS CUI [2,1])
C0221464 (UMLS CUI [2,2])
C0040405 (UMLS CUI [2,3])
C0026752 (UMLS CUI [2,4])
C2349975 (UMLS CUI [3,1])
C0221464 (UMLS CUI [3,2])
C0024485 (UMLS CUI [3,3])
C0026752 (UMLS CUI [3,4])
C1710661 (UMLS CUI [4,1])
C0040405 (UMLS CUI [4,2])
C0026752 (UMLS CUI [4,3])
C1710661 (UMLS CUI [5,1])
C0024485 (UMLS CUI [5,2])
C0026752 (UMLS CUI [5,3])
ECOG performance status
Item
3. eastern cooperative oncology group performance status 0 1 2
boolean
C1520224 (UMLS CUI [1])
Age
Item
4. age ≥ 20 and 70 or less
boolean
C0001779 (UMLS CUI [1])
Patient Inappropriate Excision | Patient Inappropriate Transplantation | Patient Inappropriate Radiofrequency ablation
Item
5. unsuitable for resection or transplant or radiofrequency ablation (rfa)
boolean
C0030705 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0728940 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C0040732 (UMLS CUI [2,3])
C0030705 (UMLS CUI [3,1])
C1548788 (UMLS CUI [3,2])
C0850292 (UMLS CUI [3,3])
Patient Inappropriate TACE | Patient Inappropriate Drug-eluting Embolic Bead | Refractory TACE | Refractory Drug-eluting Embolic Bead
Item
6. unsuitable for or refractory to tace or drug eluting beads (deb)
boolean
C0030705 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C3539919 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C3273294 (UMLS CUI [2,3])
C0205269 (UMLS CUI [3,1])
C3539919 (UMLS CUI [3,2])
C0205269 (UMLS CUI [4,1])
C3273294 (UMLS CUI [4,2])
Informed Consent
Item
7. agreement of study-specific informed consent
boolean
C0021430 (UMLS CUI [1])
Assessment Radiation Oncologist | Assessment Medical oncologist | Assessment Hepatologist
Item
8. assessment by radiation oncologist and medical oncologist or hepatologist within 28 days prior to study entry?
boolean
C1516048 (UMLS CUI [1,1])
C1514693 (UMLS CUI [1,2])
C1516048 (UMLS CUI [2,1])
C1555767 (UMLS CUI [2,2])
C1516048 (UMLS CUI [3,1])
C4280018 (UMLS CUI [3,2])
Child-Pugh Classification
Item
9. child-pugh score a-b within 7 days prior to study entry
boolean
C2347612 (UMLS CUI [1])
Liver normal | Liver minus Gross tumor volume
Item
10. normal liver (liver minus gross tumor volume) ≥ 700 cc
boolean
C0577059 (UMLS CUI [1])
C0023884 (UMLS CUI [2,1])
C0332288 (UMLS CUI [2,2])
C0475645 (UMLS CUI [2,3])
Hematologic Tests Required
Item
11. blood work requirements
boolean
C0018941 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
Absolute neutrophil count | Platelet Count measurement | Hemoglobin measurement
Item
absolute neutrophil count (anc) ≥ 1,500 /mm3, platelet ≥ 70,000/mm3, hgb ≥ 8 g/dl
boolean
C0948762 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
Liver function | Serum total bilirubin measurement | International Normalized Ratio | Albumin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
liver function test (lft): total bilirubin<3.0 mg/dl, international normalized ratio(inr) < 1.7, albumin ≥ 2.8g/dl, aspartate aminotransferase (ast)/alanine aminotransferase (alt)< 6 x normal
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0525032 (UMLS CUI [3])
C0201838 (UMLS CUI [4])
C0201899 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
Creatinine measurement, serum | Creatinine clearance measurement
Item
serum creatinine < 1.5 x normal, or creatinine clearance ≥ 60 ml/min
boolean
C0201976 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Gender Contraceptive methods
Item
12. male, consent contraception at least 6 months
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Childbearing Potential Contraceptive methods
Item
13. childbearing potential woman, consent contraception at least 6 months
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Life Expectancy
Item
14. life expectancy more than 12 weeks
boolean
C0023671 (UMLS CUI [1])
Breathing Stable Duration
Item
15. stable breathing more than 5 minutes
boolean
C0035203 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0449238 (UMLS CUI [1,3])
Main portal vein Complete obstruction | Pregnancy | Breast Feeding | Prior radiation therapy Upper abdomen | Comorbidity Uncontrolled | Second Primary Cancers | Ascites Uncontrolled | Hepatic Encephalopathy Uncontrolled | Connective Tissue Diseases | Hypersensitivity Therapeutic radiology procedure
Item
1. complete obstruction of main portal vein 2. pregnant and/or breastfeeding woman 3. previous upper abdominal rt history 4. uncontrolled active co-morbidity 5. another primary cancer history within 2 years 6. uncontrolled ascites or hepatic encephalopathy 7. connective tissue disease which known as radiation hypersensitivity
boolean
C1183135 (UMLS CUI [1,1])
C0001168 (UMLS CUI [1,2])
C0032961 (UMLS CUI [2])
C0006147 (UMLS CUI [3])
C0279134 (UMLS CUI [4,1])
C2937240 (UMLS CUI [4,2])
C0009488 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
C0751623 (UMLS CUI [6])
C0003962 (UMLS CUI [7,1])
C0205318 (UMLS CUI [7,2])
C0019151 (UMLS CUI [8,1])
C0205318 (UMLS CUI [8,2])
C0009782 (UMLS CUI [9])
C0020517 (UMLS CUI [10,1])
C1522449 (UMLS CUI [10,2])
Peptic Ulcer Moderate Uncontrolled | Varices Esophagogastric Moderate Uncontrolled | Peptic Ulcer Severe Uncontrolled | Varices Esophagogastric Severe Uncontrolled
Item
8. uncontrolled moderate to severe gastroduodenal ulcer or esophagogastric varices
boolean
C0030920 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0042345 (UMLS CUI [2,1])
C0475468 (UMLS CUI [2,2])
C0205081 (UMLS CUI [2,3])
C0205318 (UMLS CUI [2,4])
C0030920 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0205318 (UMLS CUI [3,3])
C0042345 (UMLS CUI [4,1])
C0475468 (UMLS CUI [4,2])
C0205082 (UMLS CUI [4,3])
C0205318 (UMLS CUI [4,4])