Study Subject Eligible
Item
participants will be eligible if they
boolean
C0681850 (UMLS CUI [1,1])
C1548635 (UMLS CUI [1,2])
Hepatitis C | PCR positive Genotype Specified
Item
have confirmed hepatitis c with positive pcr for genotype 1 or 3
boolean
C0019196 (UMLS CUI [1])
C3888499 (UMLS CUI [2,1])
C1148363 (UMLS CUI [2,2])
C0205369 (UMLS CUI [2,3])
Eradication Planned Hepatitis C
Item
are planned to commence on standard eradication therapy for hcv
boolean
C3178994 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C0019196 (UMLS CUI [1,3])
Age
Item
aged 18 or over
boolean
C0001779 (UMLS CUI [1])
Exclusion Criteria
Item
exclusion criteria are:
boolean
C0680251 (UMLS CUI [1])
Hepatitis C virus genotype | Exception Genotype Specified
Item
hepatitis c genotype other than 1 or 3
boolean
C1148363 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1148363 (UMLS CUI [2,2])
C0205369 (UMLS CUI [2,3])
Medical contraindication Interferon With Ribavirin
Item
contraindications to interferon / ribavirin therapy
boolean
C1301624 (UMLS CUI [1,1])
C3652465 (UMLS CUI [1,2])
C0332287 (UMLS CUI [1,3])
C0035525 (UMLS CUI [1,4])
Renal function GFR estimation by MDRD
Item
egfr <30 ml/min (by mdrd4 method)
boolean
C2170215 (UMLS CUI [1])
Decompensated liver disease
Item
currently decompensated liver disease
boolean
C4075847 (UMLS CUI [1])
Ascites | Encephalopathy | Bleeding varices
Item
o ascites, encephalopathy or variceal bleeding
boolean
C0003962 (UMLS CUI [1])
C0085584 (UMLS CUI [2])
C0333106 (UMLS CUI [3])
Kidney Calculi
Item
history of renal calculi
boolean
C0022650 (UMLS CUI [1])
Serum calcium measurement
Item
serum calcium <2.15 mmol/l or >2.60 mmol/l
boolean
C0728876 (UMLS CUI [1])
Sarcoidosis | Neoplasm Metastasis
Item
history of sarcoidosis, metastatic malignancy
boolean
C0036202 (UMLS CUI [1])
C0027627 (UMLS CUI [2])
Liver carcinoma
Item
hepatocellular carcinoma (current or previous)
boolean
C2239176 (UMLS CUI [1])
Vitamin D U/day
Item
taking >400 units/day of vitamin d
boolean
C0042866 (UMLS CUI [1,1])
C0456683 (UMLS CUI [1,2])
HIV Seropositivity
Item
hiv positive
boolean
C0019699 (UMLS CUI [1])
Pregnancy
Item
pregnancy
boolean
C0032961 (UMLS CUI [1])
Breast Feeding
Item
breastfeeding
boolean
C0006147 (UMLS CUI [1])
Childbearing Potential Contraceptive methods Absent
Item
of childbearing potential and not taking reliable contraception
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Informed Consent Unable
Item
unable to provide written informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])