Hepatitis B, Chronic
Item
chronic hepatitis b
boolean
C0524909 (UMLS CUI [1])
Age
Item
age ≥ 20 year old
boolean
C0001779 (UMLS CUI [1])
Lamivudine | adefovir | Combined Modality Therapy | Hepatitis B, Chronic
Item
currently taking lamivudine and adefovir combination therapy or adefovir monotherapy for chronic hbv infection for 24 weeks
boolean
C0209738 (UMLS CUI [1])
C0050175 (UMLS CUI [2])
C0009429 (UMLS CUI [3])
C0524909 (UMLS CUI [4])
Mutation Resistant to Lamivudine
Item
proven lamivudine resistant mutation
boolean
C0026882 (UMLS CUI [1,1])
C0332325 (UMLS CUI [1,2])
C0209738 (UMLS CUI [1,3])
Hepatitis B DNA Measurement
Item
hbv dna levels at screening ≥ 15 iu/ml
boolean
C3641250 (UMLS CUI [1])
Postmenopausal state | Female infertility | Gender Urine pregnancy test negative
Item
females must be post-menopausal, unable to conceive, or test negative for pregnancy via urine test
boolean
C0232970 (UMLS CUI [1])
C0021361 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0430057 (UMLS CUI [3,2])
Informed Consent | Protocol Compliance
Item
patient is able to give written informed consent prior to study start and to comply with the study requirements
boolean
C0021430 (UMLS CUI [1])
C0525058 (UMLS CUI [2])
Decompensated cirrhosis of liver | Liver carcinoma
Item
a history or current of decompensated cirrhosis or hepatocellular carcinoma
boolean
C1619727 (UMLS CUI [1])
C2239176 (UMLS CUI [2])
Antiviral Therapy | Immunomodulation | Cytotoxic therapy | Steroid therapy
Item
currently receiving antiviral, immunomodulatory, cytotoxic or corticosteroid therapy
boolean
C0280274 (UMLS CUI [1])
C1963758 (UMLS CUI [2])
C0677881 (UMLS CUI [3])
C0149783 (UMLS CUI [4])
HCV coinfection | HIV coinfection
Item
co-infected with hcv or hiv
boolean
C1698259 (UMLS CUI [1])
C4062778 (UMLS CUI [2])
Organ Transplantation
Item
a history of organ transplantation
boolean
C0029216 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or breast-feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Substance Use Disorders
Item
current clinically relevant of abuse of alcohol or drugs.
boolean
C0038586 (UMLS CUI [1])
Immune System Diseases | Gastrointestinal Disease | Kidney Disease | Creatinine measurement, serum | Hematological Disease | Mental disorders | Bronchopulmonary disease | Biliary System Disorder | Exception CHOLELITHIASIS ASYMPTOMATIC | Nervous system disorder | Heart Disease | Malignant disease | Hypersensitivity | Illness Interferes with Therapy
Item
significant immunocompromised, gastrointestinal, renal(serum creatinine ≥ 1.5 mg/dl), hematological, psychiatric, bronchopulmonary, biliary diseases excluding asymptomatic gb stone, neurological, cardiac, oncologic, allergic disease or medical illness that in the investigator's opinion might interfere with therapy
boolean
C0021053 (UMLS CUI [1])
C0017178 (UMLS CUI [2])
C0022658 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0018939 (UMLS CUI [5])
C0004936 (UMLS CUI [6])
C1096000 (UMLS CUI [7])
C3275124 (UMLS CUI [8])
C1705847 (UMLS CUI [9,1])
C0742393 (UMLS CUI [9,2])
C0027765 (UMLS CUI [10])
C0018799 (UMLS CUI [11])
C0442867 (UMLS CUI [12])
C0020517 (UMLS CUI [13])
C0221423 (UMLS CUI [14,1])
C0521102 (UMLS CUI [14,2])
C0087111 (UMLS CUI [14,3])
Malignant Neoplasms
Item
malignancy in previous 5 years
boolean
C0006826 (UMLS CUI [1])