Age
Item
1. male or female between the ages of 35 to 80.
boolean
C0001779 (UMLS CUI [1])
Osteoarthritis of the hand Criteria Fulfill
Item
2. must fulfill 1990 american college of rheumatology (acr) hand osteoarthritis (oa) criteria
boolean
C0263746 (UMLS CUI [1,1])
C0243161 (UMLS CUI [1,2])
C1550543 (UMLS CUI [1,3])
Erosive osteoarthritis Hand Radiography
Item
3. must have radiographic evidence of erosive hand oa
boolean
C0451840 (UMLS CUI [1,1])
C0018563 (UMLS CUI [1,2])
C0034571 (UMLS CUI [1,3])
Signs and Symptoms Arthritis of joint of hand Quantity
Item
4. have one or more clinical signs and symptoms of active inflammation in at least three hand joints
boolean
C0037088 (UMLS CUI [1,1])
C0409208 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Hand Pain intensity Assessment Score
Item
5. subject assessment of hand pain intensity in at least one hand is ≥ 6.
boolean
C0018563 (UMLS CUI [1,1])
C1320357 (UMLS CUI [1,2])
C1516048 (UMLS CUI [1,3])
C0449820 (UMLS CUI [1,4])
Global assessment Arthritis Status Score
Item
6. patient global assessment of arthritis status is ≥ 6.
boolean
C0281858 (UMLS CUI [1,1])
C0003864 (UMLS CUI [1,2])
C0449438 (UMLS CUI [1,3])
C0449820 (UMLS CUI [1,4])
Exposure to Interleukin 1 Receptor Antagonists | Exposure to Adrenal Cortex Hormones | INTRAARTICULAR HYALURONIC ACID Injection Hand joint | Therapeutic immunosuppression biological | Immunosuppressive Agents Oral
Item
1. previous exposure to any anti-interleukin-1 treatment, to corticosteroids within 1 month prior to screening, to intra-articular hyaluronic acid injection into hand joint(s) within 6 months prior to screening, to any immunosuppressive biologic therapy within 1 month or 5 half-lives (whichever is longer) prior to the first dose of study drug, or current use of immunosuppressive oral medications within 3 months or 5 half-lives (whichever is longer) prior to the first dose of study drug.
boolean
C0332157 (UMLS CUI [1,1])
C2917260 (UMLS CUI [1,2])
C0332157 (UMLS CUI [2,1])
C0001617 (UMLS CUI [2,2])
C0493951 (UMLS CUI [3,1])
C1533685 (UMLS CUI [3,2])
C0459470 (UMLS CUI [3,3])
C0021079 (UMLS CUI [4,1])
C0205460 (UMLS CUI [4,2])
C0021081 (UMLS CUI [5,1])
C1527415 (UMLS CUI [5,2])
Absolute neutrophil count
Item
2. absolute neutrophil count < 2,000 mm3
boolean
C0948762 (UMLS CUI [1])
Diagnosis Quantity
Item
3. diagnosis of one or more of the following:
boolean
C0011900 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Fibromyalgia
Item
fibromyalgia,
boolean
C0016053 (UMLS CUI [1])
Arthritis | Rheumatoid Arthritis | Spondylarthropathy Peripheral Seronegative
Item
inflammatory arthritis such as rheumatoid arthritis, peripheral seronegative spondyloarthropathy,
boolean
C0003864 (UMLS CUI [1])
C0003873 (UMLS CUI [2])
C0949691 (UMLS CUI [3,1])
C0205100 (UMLS CUI [3,2])
C0521144 (UMLS CUI [3,3])
Arthritis, Psoriatic | Psoriasis
Item
psoriatic arthritis, psoriasis,
boolean
C0003872 (UMLS CUI [1])
C0033860 (UMLS CUI [2])
Crystal Arthropathy Affecting Hands | Gout | Pseudogout
Item
microcrystalline (including gout and pseudo gout) arthritis affecting the hands,
boolean
C0152087 (UMLS CUI [1,1])
C0392760 (UMLS CUI [1,2])
C0018563 (UMLS CUI [1,3])
C0018099 (UMLS CUI [2])
C0033802 (UMLS CUI [3])
Osteoarthritis of the hand Due to Communicable Disease | Osteoarthritis of the hand Due to Episode Traumatic | Secondary osteoarthritis | Osteoarthritis Relationship Cartilage dysplasia | Osteoarthritis Relationship Bone dysplasia
Item
any oa of the hands due to an infectious origin or acute traumatic episode, secondary oa or oa linked to cartilage and bone dysplasia,
boolean
C0263746 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C0009450 (UMLS CUI [1,3])
C0263746 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C0332189 (UMLS CUI [2,3])
C0332663 (UMLS CUI [2,4])
C2732281 (UMLS CUI [3])
C0029408 (UMLS CUI [4,1])
C0439849 (UMLS CUI [4,2])
C0007301 (UMLS CUI [4,3])
C0334044 (UMLS CUI [4,4])
C0029408 (UMLS CUI [5,1])
C0439849 (UMLS CUI [5,2])
C0005941 (UMLS CUI [5,3])
Chronic pain syndrome Interferes with Assessment Hand pain
Item
other chronic painful syndromes that could interfere with assessment of pain at the hand(s).
boolean
C1298685 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C1516048 (UMLS CUI [1,3])
C0239833 (UMLS CUI [1,4])
Illness Uncontrolled | Therapy Unstable
Item
4. any uncontrolled medical illness or an unstable treatment or therapy.
boolean
C0221423 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0087111 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
Heart Disease
Item
5. clinically significant cardiac disease.
boolean
C0018799 (UMLS CUI [1])
Dysplasia | Malignant Neoplasms | Exception Squamous cell carcinoma of skin Treated | Exception Basal cell carcinoma Treated | Exception Carcinoma in situ of uterine cervix Localized
Item
6. evidence of dysplasia or history of malignancy other than a successfully treated non-metastatic cutaneous squamous cell or basal cell carcinoma or localized carcinoma in situ of the cervix.
boolean
C0334044 (UMLS CUI [1])
C0006826 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0007117 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C0851140 (UMLS CUI [5,2])
C0392752 (UMLS CUI [5,3])
Chronic infectious disease Persistent Hospitalization Required | Communicable Disease Hospitalization Required | Microbicides | Antibiotics
Item
7. history of persistent chronic or active infection(s) requiring hospitalization or treatment with antimicrobials/antibiotics.
boolean
C0151317 (UMLS CUI [1,1])
C0205322 (UMLS CUI [1,2])
C1708385 (UMLS CUI [1,3])
C0009450 (UMLS CUI [2,1])
C1708385 (UMLS CUI [2,2])
C1136254 (UMLS CUI [3])
C0003232 (UMLS CUI [4])
Reason Preventing MRI
Item
8. any reason that prohibits a subject to undergo an mri.
boolean
C0392360 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])