Age
Item
age: 18~70 years old;
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status (ps) score: 0~1 score;
boolean
C1520224 (UMLS CUI [1])
Retreatment BREAST CANCER METASTATIC RECURRENT CT scan
Item
all patients were diagnosed as recurrent metastatic breast cancer retreatment by histopathology and computed tomography (ct) examination;
boolean
C0376495 (UMLS CUI [1,1])
C0741681 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
Nidus Measurable | Nidus Diameter CT scan | Nidus Diameter MRI scan | Nidus Diameter Spiral CT scan
Item
the measurable nidus≥1: patients whose nidus diameter ≥ 20 mm by normal ct or magnetic resonance image (mri) scanning, and ≥ 10 mm by spiral ct scanning;
boolean
C1628997 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
C1628997 (UMLS CUI [2,1])
C1301886 (UMLS CUI [2,2])
C0040405 (UMLS CUI [2,3])
C1628997 (UMLS CUI [3,1])
C1301886 (UMLS CUI [3,2])
C0024485 (UMLS CUI [3,3])
C1628997 (UMLS CUI [4,1])
C1301886 (UMLS CUI [4,2])
C0860888 (UMLS CUI [4,3])
Hematologic function | Liver function | Renal function | Electrolytes normal | Cardiac function | White Blood Cell Count procedure | Neutrophil count | Platelet Count measurement
Item
patients whose blood routine, hepatorenal function, electrolyte and cardiac function were basically normal without dysfunction of primary organs. white blood cell count (wbc) ≥4.0×109/l, neutrophile granulocyte count ≥1.5×109/l, platelet (plt) count
boolean
C0221130 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
C0438240 (UMLS CUI [4])
C0232164 (UMLS CUI [5])
C0023508 (UMLS CUI [6])
C0200633 (UMLS CUI [7])
C0032181 (UMLS CUI [8])
Hemoglobin measurement | Serum total bilirubin measurement | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Creatinine measurement, serum
Item
≥100×109/l, hemoglobin (hgb) ≥95 g/l, serum bilirubin (bil) ≤1.5-fold upper limit of normal value, alanine transaminase (alt) and aspartate aminotransferase (ast) ≤2-fold upper limit of normal value, and serum creatinine (scr) ≤1.5mg/dl;
boolean
C0518015 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0201899 (UMLS CUI [4])
C0201976 (UMLS CUI [5])
Life Expectancy
Item
the expected survival time >3 months;
boolean
C0023671 (UMLS CUI [1])
Comprehension Study Protocol | Informed Consent
Item
patients who could understand this study status and had signed the informed consent forms.
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2])
Allergic Reaction Biological Agents
Item
patients who had history of allergic responses to biological agents;
boolean
C1527304 (UMLS CUI [1,1])
C0005515 (UMLS CUI [1,2])
Cancer treatment Other
Item
patients who were receiving other anti-tumor therapies;
boolean
C0920425 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Nidus Measurable Lacking
Item
patients without measureable nidus;
boolean
C1628997 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])
CNS metastases Uncontrolled | Organ dysfunction | Heart Diseases Severe | Congestive heart failure | Cardiac Arrhythmia Uncontrolled | Angina Pectoris | Heart valve disease | Myocardial Infarction | Refractory hypertension Requirement Administration of medication Long-term | Wounds Infectious chronic | Psychotic Disorders Uncontrolled | Pregnancy | Breast Feeding
Item
others, including one of the following conditions: patients with uncontrolled central nervous system (cns) metastatic nidi, with dysfunction of important organs and severe cardiac diseases (congestive heart failure, uncontrollable arrhythmia, and angina pectoris, valvular heart disease, myocardial infarction and refractory hypertension that required long-term drug administration), with chronic infectious wound and with history of uncontrollable psychosis, and women in pregnant or lactation period.
boolean
C0686377 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0349410 (UMLS CUI [2])
C0018799 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0018802 (UMLS CUI [4])
C0003811 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
C0002962 (UMLS CUI [6])
C0018824 (UMLS CUI [7])
C0027051 (UMLS CUI [8])
C0860493 (UMLS CUI [9,1])
C1514873 (UMLS CUI [9,2])
C3469597 (UMLS CUI [9,3])
C0443252 (UMLS CUI [9,4])
C0043250 (UMLS CUI [10,1])
C0009450 (UMLS CUI [10,2])
C0205191 (UMLS CUI [10,3])
C0033975 (UMLS CUI [11,1])
C0205318 (UMLS CUI [11,2])
C0032961 (UMLS CUI [12])
C0006147 (UMLS CUI [13])