Age
Item
Male and female subjects 30 to 60 years of age inclusive with chromosome karyotype of down syndrome due to trisomy 21.
boolean
C0001779 (UMLS CUI [1])
C3537167 (UMLS CUI [2])
Caregiver
Item
Patient must have a study partner (parent or other reliable caregiver) who has at least 10 hours of contact and who agrees to accompany the subject to all clinic visits and provide information about the subject's behavior and symptoms.
boolean
C0085537 (UMLS CUI [1,1])
C1521721 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
Verbal communication
Item
Patient is able to speak/communicate.
boolean
C0564215 (UMLS CUI [1])
MRI
Item
Patient is willing and has no contraindications to MRI scanning.
boolean
C0024485 (UMLS CUI [1])
Informed consent
Item
Patient or parent/legal guardian provides consent
boolean
C0021430 (UMLS CUI [1])
C0600634 (UMLS CUI [2])
C0021430 (UMLS CUI [3,1])
C0023226 (UMLS CUI [3,2])
Data privacy
Item
Patient must agree to allow for indefinite storage of his/her data and samples.
boolean
C0242578 (UMLS CUI [1,1])
C0332187 (UMLS CUI [1,2])
Inability to communicate verbally
Item
Patients is anarthric or mute.
boolean
C0234517 (UMLS CUI [1])
C0278249 (UMLS CUI [2])
Diagnosis
Item
Patient does not fulfill the criteria for the diagnosis of Down Syndrome
boolean
C0011900 (UMLS CUI [1,1])
C0013080 (UMLS CUI [1,2])
Procedure compliance
Item
Patient is unwilling or unable to participate in all tests and procedures.
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
Unstable general condition
Item
Patient has unstable medical or behavioral issues.
boolean
C0004927 (UMLS CUI [1,1])
C0443343 (UMLS CUI [1,2])
C3843040 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
Body-imaging
Item
Patient is unable or unwilling to perform MRI and/or PET imaging.
boolean
C0024485 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0024485 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
C0032743 (UMLS CUI [3,1])
C1299582 (UMLS CUI [3,2])
C0032743 (UMLS CUI [4,1])
C0558080 (UMLS CUI [4,2])