Diffuse Large B-Cell Lymphoma de novo | Diffuse Large B-Cell Lymphoma Transformation Follicular Lymphoma | Biopsy tissue
Item
diagnosis of diffuse large b-cell lymphoma (dlbcl) (de novo or dlbcl transformed from follicular lymphoma on the basis of a tissue biopsy).
boolean
C0079744 (UMLS CUI [1,1])
C1515568 (UMLS CUI [1,2])
C0079744 (UMLS CUI [2,1])
C0040682 (UMLS CUI [2,2])
C0024301 (UMLS CUI [2,3])
C3864006 (UMLS CUI [3])
Prior Therapy Quantity Aggressive Non-Hodgkin Lymphoma | Prior Therapy Quantity Diffuse Large B-Cell Lymphoma Aggressive
Item
received at least one prior therapy for aggressive non-hodgkin's lymphoma (nhl) (dlbcl)
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1332225 (UMLS CUI [1,3])
C1514463 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0079744 (UMLS CUI [2,3])
C0580822 (UMLS CUI [2,4])
Measurable Disease
Item
patients must have measurable disease.
boolean
C1513041 (UMLS CUI [1])
ECOG performance status
Item
ecog (eastern cooperative oncology group) performance status (ps) ≤ 2
boolean
C1520224 (UMLS CUI [1])
Left ventricular ejection fraction Echocardiography | Left ventricular ejection fraction MUGA scan
Item
left ventricular ejection fraction (lvef) ≥ the lower limit of normal (lln) for the institution (as per local standard of care) as measured by echocardiogram (echo) or multiple gated acquisition (muga) scan
boolean
C0428772 (UMLS CUI [1,1])
C0013516 (UMLS CUI [1,2])
C0428772 (UMLS CUI [2,1])
C0521317 (UMLS CUI [2,2])
Bone Marrow function | Liver function | Renal function
Item
adequate bone marrow, liver and renal function.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Site Only Disease | Lymph node palpable Invisible Imaging studies | Skin lesion | Bone Marrow Involvement
Item
any of the following as the only site(s) of disease: palpable lymph nodes not visible on imaging studies, skin lesions, or bone marrow involvement only
boolean
C1515974 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
C0012634 (UMLS CUI [1,3])
C1112395 (UMLS CUI [2,1])
C0205398 (UMLS CUI [2,2])
C1881134 (UMLS CUI [2,3])
C0037284 (UMLS CUI [3])
C1517677 (UMLS CUI [4])
Communicable Disease CTCAE Grades
Item
active ctcae (common terminology criteria for adverse events) grade 3/4 infection
boolean
C0009450 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
HIV Infection
Item
known history of human immunodeficiency virus (hiv) infection
boolean
C0019693 (UMLS CUI [1])
Central Nervous System Involvement Lymphoma
Item
current central nervous system (cns) involvement by lymphoma
boolean
C4050309 (UMLS CUI [1,1])
C0024299 (UMLS CUI [1,2])
Angina, Unstable | Angina Pectoris New onset | Myocardial Infarction
Item
unstable angina (angina symptoms at rest), new-onset angina (begun within the last 3 months). myocardial infarction within the past 6 months before start of study treatment
boolean
C0002965 (UMLS CUI [1])
C0002962 (UMLS CUI [2,1])
C0746890 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3])
Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus, Non-Insulin-Dependent | Hemoglobin A1c measurement | Plasma fasting glucose measurement
Item
type i or ii diabetes mellitus with hba1c > 8.5% or fasting plasma glucose > 160 mg/dl at screening.
boolean
C0011854 (UMLS CUI [1])
C0011860 (UMLS CUI [2])
C0474680 (UMLS CUI [3])
C0583513 (UMLS CUI [4])
Heart Disease New York Heart Association Classification
Item
new york heart association (nyha) class iii or iv heart disease
boolean
C0018799 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
Study Subject Participation Status
Item
concurrent participation in other clinical studies.
boolean
C2348568 (UMLS CUI [1])
copanlisib | Phosphatidylinositide 3-Kinase Inhibitor
Item
patients who previously received therapy with copanlisib or other pi3k inhibitors are not eligible for enrollment.
boolean
C4049141 (UMLS CUI [1])
C1519050 (UMLS CUI [2])