Metformin Dose Stable | Sulfonylurea Dose Stable
Item
have been treated with a stable dose of metformin for at least 3 months and have been treated with an optimally effective and stable dose of an sulfonylurea for at least 6 months prior to screening.
boolean
C0025598 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0205360 (UMLS CUI [1,3])
C0038766 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0205360 (UMLS CUI [2,3])
Hemoglobin A1c measurement
Item
hba1c value between 7.0% and 10.0%, inclusive.
boolean
C0474680 (UMLS CUI [1])
Body mass index
Item
body mass index (bmi) between 20 and 45 kilograms/square meter (kg/m^2), inclusive.
boolean
C1305855 (UMLS CUI [1])
Diabetes Mellitus, Insulin-Dependent
Item
known type 1 diabetes mellitus.
boolean
C0011854 (UMLS CUI [1])
Hypoglycaemic episode Severe Quantity
Item
more than 1 episode of severe hypoglycemia within 6 months prior to screening.
boolean
C0745153 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Emergency department visit Quantity | Hospitalization Quantity | Etiology GLUCOSE CONTROL Poor
Item
two or more emergency room visits or hospitalizations due to poor glucose control in the 6 months prior to screening.
boolean
C0586082 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0019993 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0015127 (UMLS CUI [3,1])
C0726398 (UMLS CUI [3,2])
C0542537 (UMLS CUI [3,3])
Gastrointestinal Disease Severe Impact Gastric Emptying | Gastrointestinal Disease Severe Impact Gastric motility | Gastric Bypass | Gastric banding
Item
severe gastrointestinal disease that may significantly impact gastric emptying or motility or having undergone gastric bypass or gastric banding surgery.
boolean
C0017178 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C4049986 (UMLS CUI [1,3])
C0017127 (UMLS CUI [1,4])
C0017178 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C4049986 (UMLS CUI [2,3])
C0232572 (UMLS CUI [2,4])
C0017125 (UMLS CUI [3])
C1960832 (UMLS CUI [4])
Pancreatitis
Item
previous history or active diagnosis of pancreatitis.
boolean
C0030305 (UMLS CUI [1])
Hepatitis B surface antigen positive | Hepatitis C antibody positive
Item
positive hepatitis b surface antigen or hepatitis c antibody.
boolean
C0149709 (UMLS CUI [1])
C0281863 (UMLS CUI [2])
Sign or Symptom Liver disease | Transaminases Hepatic Increased | Alanine aminotransferase increased | Alkaline phosphatase raised | Independent of Metabolic Bone Disorder
Item
clinical signs or symptoms of liver disease, or hepatic aminotransferases (aminotransferase or alanine aminotransferase) greater than 2.0× upper limit of normal (uln) or elevated alkaline phosphatase (greater than uln) unrelated to bone metabolic disease.
boolean
C3540840 (UMLS CUI [1,1])
C0023895 (UMLS CUI [1,2])
C0002594 (UMLS CUI [2,1])
C0205054 (UMLS CUI [2,2])
C0205217 (UMLS CUI [2,3])
C0151905 (UMLS CUI [3])
C0151849 (UMLS CUI [4])
C0332291 (UMLS CUI [5,1])
C0005944 (UMLS CUI [5,2])
Elevated total bilirubin | Sign or Symptom Suspicious Liver Cirrhosis | History of Liver Cirrhosis
Item
elevated total bilirubin level (greater than uln), clinically suspicious signs/symptoms of cirrhosis or history of cirrhosis.
boolean
C0741494 (UMLS CUI [1])
C3540840 (UMLS CUI [2,1])
C0750493 (UMLS CUI [2,2])
C0023890 (UMLS CUI [2,3])
C0262926 (UMLS CUI [3,1])
C0023890 (UMLS CUI [3,2])
Neuroendocrine Tumors | History of Neuroendocrine Tumors | Family history of multiple endocrine neoplasia Type Any | Von Hippel-Lindau Syndrome
Item
current diagnosis, personal history of neuroendocrine tumors, family history of any type of multiple endocrine neoplasia (men), or von hippel-lindau.
boolean
C0206754 (UMLS CUI [1])
C0262926 (UMLS CUI [2,1])
C0206754 (UMLS CUI [2,2])
C4039247 (UMLS CUI [3,1])
C0332307 (UMLS CUI [3,2])
C1552551 (UMLS CUI [3,3])
C0019562 (UMLS CUI [4])
Contraindication Magnetic Resonance Imaging
Item
contraindications for magnetic resonance imaging.
boolean
C0522473 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])