Major Depressive Disorder With Distress Anxious | Generalized Anxiety Disorder Comorbid | Social anxiety disorder | Panic Disorder
Item
participant must meet the diagnostic and statistical manual of mental disorders-iv (dsm-iv) or 5 diagnostic criteria for major depressive disorder (mdd) with anxious distress; participants with a diagnosis of comorbid generalized anxiety disorder, social anxiety disorder, or panic disorder may be included, if the investigator considers mdd with anxious distress to be the primary diagnosis
boolean
C1269683 (UMLS CUI [1,1])
C0332287 (UMLS CUI [1,2])
C0231303 (UMLS CUI [1,3])
C0003467 (UMLS CUI [1,4])
C0270549 (UMLS CUI [2,1])
C1275743 (UMLS CUI [2,2])
C4237417 (UMLS CUI [3])
C0030319 (UMLS CUI [4])
Hamilton Depression Rating Scale 17 Item Clinical Classification
Item
a 17-item hamilton depression rating scale (hdrs17) total score greater than or equal to (>=)18
boolean
C3639712 (UMLS CUI [1])
Hamilton Depression Rating Scale 17 Item Clinical Classification | Anxiety Somatization Factor Score
Item
a hdrs17 anxiety/somatization factor score >=7
boolean
C3639712 (UMLS CUI [1])
C0003467 (UMLS CUI [2,1])
C0149779 (UMLS CUI [2,2])
C1521761 (UMLS CUI [2,3])
C0449820 (UMLS CUI [2,4])
Protocol Compliance
Item
participant must be willing and able to adhere to the prohibitions and restrictions
boolean
C0525058 (UMLS CUI [1])
Body mass index
Item
participant body mass index (bmi) must be between 18 and 35 kilogram per square meter (kg/m^2) inclusive
boolean
C1305855 (UMLS CUI [1])
DEPRESSIVE DISORDER MAJOR WITH PSYCHOTIC FEATURE | Bipolar Disorder | Obsessive-Compulsive Disorder | Post-Traumatic Stress Disorder | Borderline Personality Disorder | Eating Disorders | Schizophrenia
Item
has other psychiatric condition, including, but not limited to, mdd with psychotic features, bipolar disorder, obsessive-compulsive disorder, post-traumatic stress disorder, borderline personality disorder, eating disorder, or schizophrenia
boolean
C0743080 (UMLS CUI [1])
C0005586 (UMLS CUI [2])
C0028768 (UMLS CUI [3])
C0038436 (UMLS CUI [4])
C0006012 (UMLS CUI [5])
C0013473 (UMLS CUI [6])
C0036341 (UMLS CUI [7])
Major depressive episode Duration
Item
has a length of current major depressive episode (mde) greater than (>) 6 months
boolean
C0024517 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
Antidepressant therapy Quantity failed | Antidepressant therapy Dose Duration | Major depressive episode | Response Inadequate Selective Serotonin Reuptake Inhibitors | Response Inadequate Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)
Item
has more than 1 failed antidepressant treatment of adequate dose and duration in the current mde, not including the inadequate response to the current selective serotonin reuptake inhibitor (ssri) or serotonergic/noradrenergic reuptake inhibitor (snri) antidepressant
boolean
C1096649 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0231175 (UMLS CUI [1,3])
C1096649 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0449238 (UMLS CUI [2,3])
C0024517 (UMLS CUI [3])
C1704632 (UMLS CUI [4,1])
C0205412 (UMLS CUI [4,2])
C0360105 (UMLS CUI [4,3])
C1704632 (UMLS CUI [5,1])
C0205412 (UMLS CUI [5,2])
C1579361 (UMLS CUI [5,3])
Psychotherapy Specific Major Depressive Disorder | Cognitive Therapy Episode of Depressive disorder | Behavior Therapy Episode of Depressive disorder | Interpersonal psychotherapy Episode of Depressive disorder
Item
has initiated psychotherapy specific for mdd (such as cognitive behavioral, behavioral, or interpersonal therapy) for the current episode of depression within 6 weeks prior to screening
boolean
C0033968 (UMLS CUI [1,1])
C0205369 (UMLS CUI [1,2])
C1269683 (UMLS CUI [1,3])
C0009244 (UMLS CUI [2,1])
C0332189 (UMLS CUI [2,2])
C0011581 (UMLS CUI [2,3])
C0004933 (UMLS CUI [3,1])
C0332189 (UMLS CUI [3,2])
C0011581 (UMLS CUI [3,3])
C0871787 (UMLS CUI [4,1])
C0332189 (UMLS CUI [4,2])
C0011581 (UMLS CUI [4,3])
Feeling suicidal | Suicidal behavior
Item
has a current or recent history of clinically significant suicidal ideation within the past 6 months, or a history of suicidal behavior within the past year
boolean
C0424000 (UMLS CUI [1])
C1760428 (UMLS CUI [2])