Irritable Bowel Syndrome
Item
1. meet the diagnostic for ibs according to rome iii;
boolean
C0022104 (UMLS CUI [1])
Major Depressive Disorder
Item
2. meet the diagnostic for mdd according to mini;
boolean
C1269683 (UMLS CUI [1])
Age
Item
3. age≥18 and ≤ 65;
boolean
C0001779 (UMLS CUI [1])
Comprehension Study Protocol | Comprehension Study Protocol Guardian | Informed Consent | Informed Consent Guardian
Item
4. patients or their guardian have the ability to understand and to provide informed consent to the examination, observation, and evaluation; processes specified in this protocol, and have signed the informed consent from based on a full understanding of the trial.
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
C0162340 (UMLS CUI [2,1])
C2348563 (UMLS CUI [2,2])
C1274041 (UMLS CUI [2,3])
C0021430 (UMLS CUI [3])
C0021430 (UMLS CUI [4,1])
C1274041 (UMLS CUI [4,2])
Medical contraindication Paroxetine CR | Medical contraindication Seroxat CR
Item
1. patients were also excluded if they had any medical condition that would contraindicate the use of paroxetine cr [seroxat cr®];
boolean
C1301624 (UMLS CUI [1,1])
C0070122 (UMLS CUI [1,2])
C1707506 (UMLS CUI [1,3])
C1301624 (UMLS CUI [2,1])
C0678139 (UMLS CUI [2,2])
C1707506 (UMLS CUI [2,3])
Substance Dependence | Schizophrenia | Serious mental illness
Item
2. history of alcohol / drug dependence and schizophrenia; history of serious mental illness;
boolean
C0038580 (UMLS CUI [1])
C0036341 (UMLS CUI [2])
C3841614 (UMLS CUI [3])
Neurologic Deficits Major | Interference Comprehension Study Protocol | Neurologic Deficits Major Interfere with Informed Consent
Item
3. major neurological deficits that interfere with the patient's ability to understand the study procedures and provide a written informed consent;
boolean
C0521654 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0521102 (UMLS CUI [2,1])
C0162340 (UMLS CUI [2,2])
C2348563 (UMLS CUI [2,3])
C0521654 (UMLS CUI [3,1])
C0205164 (UMLS CUI [3,2])
C0521102 (UMLS CUI [3,3])
C0021430 (UMLS CUI [3,4])
Episode of Depressive disorder Unresponsive to Treatment | Therapeutic procedure Quantity | Antidepressive Agents | Benzodiazepines | Anti-Anxiety Agents
Item
4. patients were also excluded if their current episode of depression had failed to respond to two or more adequate trials of antidepressants, benzodiazepines, or other anxiolytics at a clinically appropriate dose for a minimum of 4 weeks;
boolean
C0332189 (UMLS CUI [1,1])
C0011581 (UMLS CUI [1,2])
C0205269 (UMLS CUI [1,3])
C0087111 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0003289 (UMLS CUI [3])
C0005064 (UMLS CUI [4])
C0040616 (UMLS CUI [5])
Feeling suicidal
Item
5. suicide ideation;
boolean
C0424000 (UMLS CUI [1])
Monoamine Oxidase Inhibitors | Benzodiazepines | Antidepressive Agents
Item
6. use monoamine oxidase inhibitors (maois), benzodiazepines or other antidepressants within at least 14 days before study begin;
boolean
C0026457 (UMLS CUI [1])
C0005064 (UMLS CUI [2])
C0003289 (UMLS CUI [3])
Other medical condition Study Subject Participation Status Excluded | Other medical condition Preventing Informed Consent | Mental condition Study Subject Participation Status Excluded | Mental condition Preventing Informed Consent
Item
7. other medical and psychological conditions prevent patients from participating in the study or signing informed consent;
boolean
C3843040 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C0332196 (UMLS CUI [1,3])
C3843040 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0021430 (UMLS CUI [2,3])
C3840291 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C0332196 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C1292733 (UMLS CUI [4,2])
C0021430 (UMLS CUI [4,3])
Pregnancy | Breast Feeding | Pregnancy, Planned
Item
8. pregnant or lactating females, or anyone who plan to become pregnant during the study period;
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])
Study Subject Participation Status
Item
9. those who are known to currently participate a clinical trial;
boolean
C2348568 (UMLS CUI [1])
Organ Disease | Gastrointestinal tract infectious disease
Item
10. those patients with significant organ disease. gi disorders that are infectious;
boolean
C0178784 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C0543767 (UMLS CUI [2])
Disease Ischemic | Disease Due to Therapeutic radiology procedure | Disease Drug-induced | Inflammatory Bowel Diseases | Crohn Disease | Ulcerative Colitis
Item
11. ischemic, radiation-induced, or medication-induced; inflammatory bowel disease (cohn's disease and ulcerative colitis);
boolean
C0012634 (UMLS CUI [1,1])
C0475224 (UMLS CUI [1,2])
C0012634 (UMLS CUI [2,1])
C0678226 (UMLS CUI [2,2])
C1522449 (UMLS CUI [2,3])
C0012634 (UMLS CUI [3,1])
C0458082 (UMLS CUI [3,2])
C0021390 (UMLS CUI [4])
C0010346 (UMLS CUI [5])
C0009324 (UMLS CUI [6])
Gastrointestinal Surgical Procedure
Item
12. recent gastrointestinal surgery (within 6 months).
boolean
C0524722 (UMLS CUI [1])
Electroconvulsive Therapy | Psychotherapy
Item
13. has received electroconvulsive therapy (ect) or psychotherapy in the 3 months prior to screening.
boolean
C0013806 (UMLS CUI [1])
C0033968 (UMLS CUI [2])
Hematology finding abnormal | Clinical Chemistry Tests Abnormal | Electrocardiogram abnormal | Physical examination abnormal | Resolution Lacking | Medical condition Study Subject Participation Status Inappropriate | Medical condition At risk Patient safety | Medical condition Interferes with Safety Assessment | Medical condition Interferes with Evaluation | Cardiovascular Disease Severe | Liver Failure | Kidney Failure
Item
14. presents with clinically significant abnormalities in haematology, clinical chemistry, electrocardiogram (ecg) or physical examination at screening which have not resolved prior to the baseline visit or has clinically significant conditions, which in the opinion of the investigator, will render the patient unsuitable for the study and pose a safety concern or interfere with the accurate safety and efficacy assessments (e.g., severe cardiovascular disease, hepatic or renal failure etc).
boolean
C0475182 (UMLS CUI [1])
C0525044 (UMLS CUI [2,1])
C0205161 (UMLS CUI [2,2])
C0522055 (UMLS CUI [3])
C0747585 (UMLS CUI [4])
C1514893 (UMLS CUI [5,1])
C0332268 (UMLS CUI [5,2])
C3843040 (UMLS CUI [6,1])
C2348568 (UMLS CUI [6,2])
C1548788 (UMLS CUI [6,3])
C3843040 (UMLS CUI [7,1])
C1444641 (UMLS CUI [7,2])
C1113679 (UMLS CUI [7,3])
C3843040 (UMLS CUI [8,1])
C0521102 (UMLS CUI [8,2])
C0549076 (UMLS CUI [8,3])
C3843040 (UMLS CUI [9,1])
C0521102 (UMLS CUI [9,2])
C0220825 (UMLS CUI [9,3])
C0007222 (UMLS CUI [10,1])
C0205082 (UMLS CUI [10,2])
C0085605 (UMLS CUI [11])
C0035078 (UMLS CUI [12])