Cutaneous T-Cell Lymphoma Ann Arbor lymphoma staging system
Item
clinically and histologically confirmed diagnosis of ctcl (early stage disease with patches and/or thin plaques covering up to 10%, stage ia)
boolean
C0079773 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
Recurrent disease | Refractory Disease | Standard therapy Skin | Adrenal Cortex Hormones | Bexarotene Topical Product | Phototherapy
Item
relapsed or refractory disease after at least one standard skin directed treatment including corticosteroids, topical bexarotene, phototherapy
boolean
C0277556 (UMLS CUI [1])
C1514815 (UMLS CUI [2])
C2936643 (UMLS CUI [3,1])
C1123023 (UMLS CUI [3,2])
C0001617 (UMLS CUI [4])
C3215536 (UMLS CUI [5])
C0031765 (UMLS CUI [6])
Age
Item
all subjects must be 18 years of age or older
boolean
C0001779 (UMLS CUI [1])
Life Expectancy
Item
life expectancy ≥ 6 months, determined by the treating physician
boolean
C0023671 (UMLS CUI [1])
Informed Consent
Item
signed informed consent
boolean
C0021430 (UMLS CUI [1])
Cancer treatment | Topical glucocorticoid | Glucocorticoids, Systemic | Chemotherapy | Therapeutic radiology procedure | Antibody therapy
Item
patients currently receiving anticancer therapies or who have received anticancer therapies within 4 weeks of the start of study drug (including topical or systemic glucocorticosteroids, chemotherapy, radiation therapy, antibody based therapy, etc.)
boolean
C0920425 (UMLS CUI [1])
C0017712 (UMLS CUI [2])
C3540777 (UMLS CUI [3])
C0392920 (UMLS CUI [4])
C1522449 (UMLS CUI [5])
C0281176 (UMLS CUI [6])
Investigational New Drugs
Item
prior treatment with any investigational drug within the preceding 4 weeks
boolean
C0013230 (UMLS CUI [1])
Systemic therapy chronic | Adrenal Cortex Hormones | Immunosuppressive Agents
Item
patients receiving chronic, systemic treatment with corticosteroids or another immunosuppressive agent.
boolean
C1515119 (UMLS CUI [1,1])
C0205191 (UMLS CUI [1,2])
C0001617 (UMLS CUI [2])
C0021081 (UMLS CUI [3])
Pregnancy | Breast Feeding | Adult Females & males of reproductive potential Contraceptive methods Absent | Contraceptives, Oral | Intrauterine Devices | Contraceptive implant | Contraceptive injection | Vaginal contraceptive diaphragm | Vaginal Spermicides | Condoms | Spermicidal Foam | Childbearing Potential Urine pregnancy test negative
Item
female patients who are pregnant or breast feeding, or adults of reproductive potential who are not using effective birth control methods. adequate contraception (oral contraceptives ("the pill"), intrauterine devices (iuds), contraceptive implants under the skin, or contraceptive injections, diaphragms with spermicide and condoms with foam) must be used throughout the trial and for 8 weeks after the last dose of study drug (women of childbearing potential must have a negative urine within 7 days prior to administration of sirolimus).
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0001675 (UMLS CUI [3,1])
C4034483 (UMLS CUI [3,2])
C0700589 (UMLS CUI [3,3])
C0332197 (UMLS CUI [3,4])
C0009905 (UMLS CUI [4])
C0021900 (UMLS CUI [5])
C1657106 (UMLS CUI [6])
C1656586 (UMLS CUI [7])
C0042241 (UMLS CUI [8])
C0087145 (UMLS CUI [9])
C0677582 (UMLS CUI [10])
C2985329 (UMLS CUI [11])
C3831118 (UMLS CUI [12,1])
C0430057 (UMLS CUI [12,2])
mTOR Inhibitor | Sirolimus | temsirolimus | everolimus
Item
patients who have received prior treatment with an mtor inhibitor (e.g., sirolimus, temsirolimus, everolimus).
boolean
C2746052 (UMLS CUI [1])
C0072980 (UMLS CUI [2])
C1707080 (UMLS CUI [3])
C0541315 (UMLS CUI [4])
Hypersensitivity Sirolimus | Hypersensitivity Everolimus | Hypersensitivity Temsirolimus | Hypersensitivity Sirolimus Excipient | Hypersensitivity Everolimus Excipient | Hypersensitivity Temsirolimus Excipient
Item
patients with a known hypersensitivity to sirolimus or other rapamycin (e.g., everolimus, temsirolimus) or to its excipient
boolean
C0020517 (UMLS CUI [1,1])
C0072980 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0541315 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C1707080 (UMLS CUI [3,2])
C0020517 (UMLS CUI [4,1])
C0072980 (UMLS CUI [4,2])
C0015237 (UMLS CUI [4,3])
C0020517 (UMLS CUI [5,1])
C0541315 (UMLS CUI [5,2])
C0015237 (UMLS CUI [5,3])
C0020517 (UMLS CUI [6,1])
C1707080 (UMLS CUI [6,2])
C0015237 (UMLS CUI [6,3])
Noncompliance with regimen (medical)
Item
history of noncompliance to medical regimens
boolean
C1408343 (UMLS CUI [1])
Protocol Compliance Unwilling | Protocol Compliance Unable
Item
patients unwilling to or unable to comply with the protocol
boolean
C0525058 (UMLS CUI [1,1])
C0558080 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])