Moderate to high risk of Non ST segment elevation acute coronary syndrome
Item
patients presenting with moderate-high risk non-steacs defined according the current guidelines
boolean
C1998133 (UMLS CUI [1,1])
C3160886 (UMLS CUI [1,2])
Loading dose Aspirin | ASPIRIN USE CHRONIC U/day Standard of Care
Item
patients received a loading dose or under chronic treatment with aspirin (100 mg per day) as per standard of care
boolean
C3714444 (UMLS CUI [1,1])
C0004057 (UMLS CUI [1,2])
C0741254 (UMLS CUI [2,1])
C0456683 (UMLS CUI [2,2])
C2936643 (UMLS CUI [2,3])
Age
Item
age between 18 and 80 years old
boolean
C0001779 (UMLS CUI [1])
Body mass index
Item
bmi between 18 and 35 kg/m2
boolean
C1305855 (UMLS CUI [1])
Informed Consent
Item
provide written informed consent prior to any study specific procedures
boolean
C0021430 (UMLS CUI [1])
Brain hemorrhage | Intracranial Hemorrhages
Item
history of hemorrhagic stroke or intracranial bleeding
boolean
C0553692 (UMLS CUI [1])
C0151699 (UMLS CUI [2])
Aspirin allergy | Hypersensitivity Ticagrelor | Hypersensitivity Clopidogrel
Item
known allergies to aspirin, ticagrelor, or clopidogrel
boolean
C0004058 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C1999375 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0070166 (UMLS CUI [3,2])
Anticoagulation Therapy Oral | Coumarin Derivative | dabigatran | rivaroxaban | apixaban
Item
on treatment with oral anticoagulation (coumarin derivate, dabigatran, rivaroxaban, apixaban)
boolean
C0003281 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C0010206 (UMLS CUI [2,1])
C1527240 (UMLS CUI [2,2])
C2348066 (UMLS CUI [3])
C1739768 (UMLS CUI [4])
C1831808 (UMLS CUI [5])
Hemoglobin measurement
Item
hemoglobin <10 gm/dl
boolean
C0518015 (UMLS CUI [1])
Platelet Count measurement
Item
platelet count <80x106/ml
boolean
C0032181 (UMLS CUI [1])
Hematological Disease | Hemorrhage | Hemodynamic instability
Item
blood dyscrasias, active bleeding or hemodynamic instability.
boolean
C0018939 (UMLS CUI [1])
C0019080 (UMLS CUI [2])
C0948268 (UMLS CUI [3])
Hemodialysis | Peritoneal Dialysis | Estimated Glomerular Filtration Rate Change | Estimated Glomerular Filtration Rate
Item
patients on hemodialysis or peritoneal dialysis, a change in estimated glomerular filtration rate (egfr) greater than 15 ml/min within 90 days prior to enrollment, or estimated glomerular filtration rate (egfr) lower than 15 ml/min/1.73m2
boolean
C0019004 (UMLS CUI [1])
C0031139 (UMLS CUI [2])
C3811844 (UMLS CUI [3,1])
C0392747 (UMLS CUI [3,2])
C3811844 (UMLS CUI [4])
Communicable Diseases | Neoplasia
Item
patients with known infectious diseases or neoplasia
boolean
C0009450 (UMLS CUI [1])
C0027651 (UMLS CUI [2])
Alanine aminotransferase increased
Item
baseline alt >2.5 times the upper limit of normal
boolean
C0151905 (UMLS CUI [1])
Sick Sinus Syndrome | AV BLOCK HIGH DEGREE | Artificial cardiac pacemaker Absent
Item
patients with sick sinus syndrome (sss) or high degree av block without pacemaker protection
boolean
C0037052 (UMLS CUI [1])
C0741311 (UMLS CUI [2])
C0030163 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
Pharmaceutical Preparations Interfere with CYP2C19 Metabolism | Fluconazole | Diflucan | Ketoconazole | Nizoral | voriconazole | Vfend | etravirine | Intelence | felbamate | Felbatol | Fluoxetine | Prozac | Symbyax | Fluvoxamine | Luvox | Ticlopidine | Ticlid
Item
drugs interfering with 2c19 metabolism (to avoid interaction with clopidogrel): fluconazole (diflucan), ketoconazole (nizoral), voriconazole (vfend), etravirine (intelence), felbamate (felbatol), fluoxetine (prozac, serafem, symbyax), fluvoxamine (luvox), and ticlopidine (ticlid). since omeprazole is the most used proton-pump inhibitor in our clinical environment, we will keep the same prescription rate in both groups to avoid differences results from this described interaction
boolean
C0013227 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C3714749 (UMLS CUI [1,3])
C0025519 (UMLS CUI [1,4])
C0016277 (UMLS CUI [2])
C0699601 (UMLS CUI [3])
C0022625 (UMLS CUI [4])
C0699439 (UMLS CUI [5])
C0393080 (UMLS CUI [6])
C1136812 (UMLS CUI [7])
C1456409 (UMLS CUI [8])
C2241753 (UMLS CUI [9])
C0060135 (UMLS CUI [10])
C0728742 (UMLS CUI [11])
C0016365 (UMLS CUI [12])
C0162373 (UMLS CUI [13])
C1330549 (UMLS CUI [14])
C0085228 (UMLS CUI [15])
C0086307 (UMLS CUI [16])
C0040207 (UMLS CUI [17])
C0733418 (UMLS CUI [18])
Pharmaceutical Preparations Interfere with CYP3A4 Metabolism | Ketoconazole | Itraconazole | voriconazole | Clarithromycin | nefazodone | Ritonavir | Saquinavir | Nelfinavir | Indinavir | Atazanavir | telithromycin
Item
drugs interfering cyp3a4 metabolism (to avoid interaction with ticagrelor): ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir saquinavir, nelfinavir, indinavir, atazanavir, and telithromizycin
boolean
C0013227 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C3714798 (UMLS CUI [1,3])
C0025519 (UMLS CUI [1,4])
C0022625 (UMLS CUI [2])
C0064113 (UMLS CUI [3])
C0393080 (UMLS CUI [4])
C0055856 (UMLS CUI [5])
C0068485 (UMLS CUI [6])
C0292818 (UMLS CUI [7])
C0286738 (UMLS CUI [8])
C0525005 (UMLS CUI [9])
C0376637 (UMLS CUI [10])
C1145759 (UMLS CUI [11])
C0907410 (UMLS CUI [12])
Pregnancy
Item
pregnant females
boolean
C0032961 (UMLS CUI [1])