Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Item
diagnosis of cll / small lymphocytic lymphoma (cll/) according to the world health organisation (who) classification 2008.
boolean
C1302547 (UMLS CUI [1])
Bendamustine/rituximab First line treatment | Bendamustine/rituximab Second line treatment
Item
patients who were treated with first and second-line bendamustine plus rituximab (br) from january 2008 to december 2014 from european centres adhering to the gimema group and the eric group.
boolean
C1328232 (UMLS CUI [1,1])
C1708063 (UMLS CUI [1,2])
C1328232 (UMLS CUI [2,1])
C1710038 (UMLS CUI [2,2])
Prior Therapy Absent | Chronic Lymphocytic Leukemia Treatment required for | bendamustine/rituximab Course Quantity
Item
previously untreated cll patients requiring therapy according to the nci criteria (hallek m et al, blood 2008 - appendix g) and treated with at least one cycle of br as first-line treatment.
boolean
C1514463 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0023434 (UMLS CUI [2,1])
C0332121 (UMLS CUI [2,2])
C1328232 (UMLS CUI [3,1])
C0750729 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
Prior Therapy Chronic Lymphocytic Leukemia | Alkylating Agents | Purine analog | Monoclonal Antibodies | Monoclonal Antibodies Absent | Patient need for Second line treatment | bendamustine/rituximab Course Quantity
Item
cll patients that received one previous line of treatment using alkylating agents and/or purine analogues with or without monoclonal antibodies, requiring second-line therapy according to the nci criteria (hallek m et al, blood 2008 - appendix g) and treated with at least one cycle of bendamustine and rituximab.
boolean
C1514463 (UMLS CUI [1,1])
C0023434 (UMLS CUI [1,2])
C0002073 (UMLS CUI [2])
C1268902 (UMLS CUI [3])
C0003250 (UMLS CUI [4])
C0003250 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0686904 (UMLS CUI [6,1])
C1710038 (UMLS CUI [6,2])
C1328232 (UMLS CUI [7,1])
C0750729 (UMLS CUI [7,2])
C1265611 (UMLS CUI [7,3])
Age
Item
age ≥ 18 years old.
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
signed written informed consent according to ich/eu/gcp and national local law.
boolean
C0021430 (UMLS CUI [1])
Prior Therapy Quantity
Item
patients who have received 2 or more lines of prior therapy.
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
Patients Have
Item
patients with:
boolean
C0030705 (UMLS CUI [1,1])
C3539897 (UMLS CUI [1,2])
Chronic lymphocytic leukaemia transformation Aggressive Lymphoma | Richter's syndrome | HIV Infection | Hepatitis C Uncontrolled | Hepatitis B Uncontrolled | Liver Cirrhosis Uncontrolled
Item
transformation of cll into aggressive lymphomas (richter's syndrome). hiv infection. active and uncontrolled hcv and/or hbv infections or liver cirrhosis.
boolean
C1142081 (UMLS CUI [1,1])
C1332225 (UMLS CUI [1,2])
C0349631 (UMLS CUI [2])
C0019693 (UMLS CUI [3])
C0019196 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
C0019163 (UMLS CUI [5,1])
C0205318 (UMLS CUI [5,2])
C0023890 (UMLS CUI [6,1])
C0205318 (UMLS CUI [6,2])