Clear Cell Renal Cell Carcinoma Advanced Locally | Clear-cell metastatic renal cell carcinoma | Disease Progression | Prior Therapy Quantity
Item
has locally advanced or metastatic ccrcc and has progressed during treatment with at least 1 prior therapeutic regimen
boolean
C0279702 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C2931852 (UMLS CUI [2])
C0242656 (UMLS CUI [3])
C1514463 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
Age
Item
is of age ≥ 18 years
boolean
C0001779 (UMLS CUI [1])
Life Expectancy
Item
has a life expectancy of ≥ 3 months
boolean
C0023671 (UMLS CUI [1])
Organ function
Item
has adequate organ function
boolean
C0678852 (UMLS CUI [1])
Female Sterilization | Postmenopausal state | Gender Contraceptive methods | Gender Partner female Contraceptive methods
Item
if a female patient, must be surgically sterile, post-menopausal, or must agree to use physician-approved method of birth control during the study and for a minimum of 30 days after the last study drug administration, or if a male patient with a female partner, must agree to use physician-approved method of birth control during the study and for a minimum of 30 days after the last study drug administration
boolean
C0015787 (UMLS CUI [1])
C0232970 (UMLS CUI [2])
C0079399 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0079399 (UMLS CUI [4,1])
C0682323 (UMLS CUI [4,2])
C0086287 (UMLS CUI [4,3])
C0700589 (UMLS CUI [4,4])
Able to swallow Oral medication
Item
able to swallow oral medications
boolean
C2712086 (UMLS CUI [1,1])
C0175795 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain Untreated | Leptomeningeal disease | Compression of spinal cord
Item
has a history of untreated brain metastasis or history of leptomeningeal disease or spinal cord compression
boolean
C0220650 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0751297 (UMLS CUI [2])
C0037926 (UMLS CUI [3])
Effect Reversible Due to Cancer treatment | Recovery failed
Item
has failed to recover from the reversible effects of prior anticancer therapy
boolean
C1280500 (UMLS CUI [1,1])
C0205343 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0920425 (UMLS CUI [1,4])
C2004454 (UMLS CUI [2,1])
C0231175 (UMLS CUI [2,2])
Uncontrolled hypertension | Poor hypertension control
Item
has uncontrolled or poorly controlled hypertension
boolean
C1868885 (UMLS CUI [1])
C0421190 (UMLS CUI [2])
Warfarin | Anticoagulant therapy | Requirement Warfarin Expected
Item
is receiving warfarin anticoagulant therapy or expected to require warfarin
boolean
C0043031 (UMLS CUI [1])
C0150457 (UMLS CUI [2])
C1514873 (UMLS CUI [3,1])
C0043031 (UMLS CUI [3,2])
C1517001 (UMLS CUI [3,3])
Cardiovascular event Major
Item
has had any major cardiovascular event within 6 months prior to study drug administration
boolean
C1320716 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
Heart Disease | Respiration Disorder | Other medical condition Interferes with Study Subject Participation Status | Mental condition Interferes with Study Subject Participation Status | Other medical condition Interferes with Interpretation Research results | Mental condition Interferes with Interpretation Research results
Item
has any other clinically significant cardiac, respiratory, or other medical or psychiatric condition that might interfere with participation in the trial or interfere with the interpretation of trial results
boolean
C0018799 (UMLS CUI [1])
C0035204 (UMLS CUI [2])
C3843040 (UMLS CUI [3,1])
C0521102 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C0521102 (UMLS CUI [4,2])
C2348568 (UMLS CUI [4,3])
C3843040 (UMLS CUI [5,1])
C0521102 (UMLS CUI [5,2])
C0459471 (UMLS CUI [5,3])
C0683954 (UMLS CUI [5,4])
C3840291 (UMLS CUI [6,1])
C0521102 (UMLS CUI [6,2])
C0459471 (UMLS CUI [6,3])
C0683954 (UMLS CUI [6,4])
Major surgery
Item
has had major surgery within 4 weeks before first study drug administration
boolean
C0679637 (UMLS CUI [1])
HIV Infection
Item
has known hiv
boolean
C0019693 (UMLS CUI [1])
Communicable Disease Requirement Systemic therapy
Item
has an active infection requiring systemic treatment
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C1515119 (UMLS CUI [1,3])
Study Subject Participation Status
Item
is participating in another therapeutic clinical trial
boolean
C2348568 (UMLS CUI [1])