Age
Item
men and women ≥ 18 years of age
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Non-small cell lung cancer recurrent | Non-small cell lung cancer metastatic | Adenocarcinoma of lung | Large cell carcinoma of lung | Squamous cell carcinoma of lung | Chemotherapy Platinum-Based | Disease Progression
Item
histologically confirmed recurrent or metastatic nsclc (adenocarcinoma, large cell, squamous cell, or not otherwise specified) that has either progressed during or after platinum-based chemotherapy
boolean
C0278517 (UMLS CUI [1])
C0278987 (UMLS CUI [2])
C0152013 (UMLS CUI [3])
C0345958 (UMLS CUI [4])
C0149782 (UMLS CUI [5])
C0392920 (UMLS CUI [6,1])
C1514162 (UMLS CUI [6,2])
C0242656 (UMLS CUI [7])
Chemotherapy Platinum-Based Quantity | EGFR gene mutation Requirement Tyrosine Kinase Inhibitors | ALK Gene Translocation Requirement Tyrosine Kinase Inhibitors
Item
received at least 1 platinum-based chemotherapy regimen. note: subjects with egfr mutations or alk translocations are required to have received prior therapy with appropriate tki; prior platinum-based chemotherapy is not required for this specific patient population
boolean
C0392920 (UMLS CUI [1,1])
C1514162 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C3266992 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C2757011 (UMLS CUI [2,3])
C4329227 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C2757011 (UMLS CUI [3,3])
Cancer Other | Exception Basal cell carcinoma Treated | Exception Squamous cell carcinoma of skin Treated | Exception Carcinoma in situ of uterine cervix | Exception Disease Free Duration
Item
prior malignancy (other than lung cancer), except for adequately treated basal cell or squamous cell skin cancer, in situ cervical cancer, or other cancer from which the subject has been disease free for ≥ 2 years or which will not limit survival to < 2 years
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1522326 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0012634 (UMLS CUI [5,2])
C0332296 (UMLS CUI [5,3])
C0449238 (UMLS CUI [5,4])
CNS metastases | Meningeal Carcinomatosis
Item
known central nervous system metastases and/or carcinomatous meningitis
boolean
C0686377 (UMLS CUI [1])
C0220654 (UMLS CUI [2])
Cardiovascular Disease | Cardiac Arrhythmia Uncontrolled | ARRHYTHMIA SYMPTOMATIC | Congestive heart failure | Myocardial Infarction
Item
significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 6 months of screening
boolean
C0007222 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0741212 (UMLS CUI [3])
C0018802 (UMLS CUI [4])
C0027051 (UMLS CUI [5])
Malabsorption Syndrome | Disease Affecting Gastrointestinal function | Stomach Excision | Small intestine excision | Inflammatory Bowel Disease Symptomatic | Partial bowel obstruction | Intestinal Obstruction Complete | Restriction Gastric | Bariatric Surgery | Gastric Bypass
Item
malabsorption syndrome, disease significantly affecting gastrointestinal function, or resection of the stomach or small bowel, symptomatic inflammatory bowel disease, partial or complete bowel obstruction, or gastric restrictions and bariatric surgery, such as gastric bypass
boolean
C0024523 (UMLS CUI [1])
C0012634 (UMLS CUI [2,1])
C0392760 (UMLS CUI [2,2])
C0516983 (UMLS CUI [2,3])
C1304699 (UMLS CUI [3])
C0192601 (UMLS CUI [4])
C0021390 (UMLS CUI [5,1])
C0231220 (UMLS CUI [5,2])
C1328480 (UMLS CUI [6])
C0021843 (UMLS CUI [7,1])
C0205197 (UMLS CUI [7,2])
C0443288 (UMLS CUI [8,1])
C1704242 (UMLS CUI [8,2])
C1456587 (UMLS CUI [9])
C0017125 (UMLS CUI [10])
Breast Feeding | Pregnancy
Item
breastfeeding or pregnant
boolean
C0006147 (UMLS CUI [1])
C0032961 (UMLS CUI [2])