Adenocarcinoma of lung TNM clinical staging | Pleural effusion | Pericardial effusion | Histology Mixed allowed | Adenocarcinoma Histology Predominant
Item
1. pathologically confirmed diagnosis of stage iiib (with cytologically proven pleural effusion or pericardial effusion) or stage iv adenocarcinoma of the lung. patients with mixed histology are eligible if adenocarcinoma is the predominant histology.
boolean
C0152013 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C0032227 (UMLS CUI [2])
C0031039 (UMLS CUI [3])
C0344441 (UMLS CUI [4,1])
C0205430 (UMLS CUI [4,2])
C0683607 (UMLS CUI [4,3])
C0001418 (UMLS CUI [5,1])
C0344441 (UMLS CUI [5,2])
C1542147 (UMLS CUI [5,3])
EGFR L858R mutation | EGFR Exon 19 Deletion Mutation
Item
2. documented egfr mutation (l858r and/or deletion 19) with no other known egfr mutation.
boolean
C3274204 (UMLS CUI [1])
C4289657 (UMLS CUI [2])
Measurable Disease
Item
3. measureable disease according to recist 1.1.
boolean
C1513041 (UMLS CUI [1])
Disease Progression Radiology | Recurrent disease Radiology | Status post First line treatment | Status post Chemotherapy Regimen Platinum-Based
Item
4. radiologically confirmed progression or recurrence of disease during or following first line therapy with a platinum-based chemotherapy regimen.
boolean
C0242656 (UMLS CUI [1,1])
C0043299 (UMLS CUI [1,2])
C0277556 (UMLS CUI [2,1])
C0043299 (UMLS CUI [2,2])
C0231290 (UMLS CUI [3,1])
C1708063 (UMLS CUI [3,2])
C0231290 (UMLS CUI [4,1])
C0392920 (UMLS CUI [4,2])
C1514162 (UMLS CUI [4,3])
ECOG performance status
Item
5. eastern cooperative oncology group (ecog) performance score of 0 or 1.
boolean
C1520224 (UMLS CUI [1])
Organ function
Item
6. adequate organ function.
boolean
C0678852 (UMLS CUI [1])
Prior Therapy Quantity Disease
Item
1. more than one line of prior therapy for disease.
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0012634 (UMLS CUI [1,3])
Chemotherapy cycle Platinum-Based Quantity | Etiology Toxicity | Etiology Intolerance Therapy
Item
2. previously received less than 3 cycles of platinum-based chemotherapy due to toxicity and/or intolerance of treatment.
boolean
C1302181 (UMLS CUI [1,1])
C1514162 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0015127 (UMLS CUI [2,1])
C0600688 (UMLS CUI [2,2])
C0015127 (UMLS CUI [3,1])
C0231199 (UMLS CUI [3,2])
C0087111 (UMLS CUI [3,3])
EGFR Targeting Tyrosine kinase inhibitor
Item
3. previous treatment with any egfr targeting tyrosine kinase inhibitor (tki) or antibody.
boolean
C0034802 (UMLS CUI [1,1])
C1521840 (UMLS CUI [1,2])
C1268567 (UMLS CUI [1,3])
Interstitial Lung Disease Pre-existing
Item
4. known pre-existing interstitial lung disease.
boolean
C0206062 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])