Non-squamous non-small cell lung cancer TNM clinical staging | Recurrent Non-Squamous Non-Small Cell Lung Carcinoma | Status post Intervention | Therapeutic radiology procedure | Operative Surgical Procedures | Chemoradiotherapy | Chemotherapy, Adjuvant | Chemotherapy Neoadjuvant | Adjuvant Chemotherapy Absent | Chemotherapy Neoadjuvant Absent
Item
histologically or cytologically confirmed diagnosis of nonsquamous nsclc that is stage iiib stage iv, or recurrent after prior definitive intervention (radiation, surgery, or chemoradiation therapy, with or without adjuvant or neoadjuvant chemotherapy).
boolean
C4324656 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C4288304 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C0184661 (UMLS CUI [3,2])
C1522449 (UMLS CUI [4])
C0543467 (UMLS CUI [5])
C0436307 (UMLS CUI [6])
C0085533 (UMLS CUI [7])
C0392920 (UMLS CUI [8,1])
C1298676 (UMLS CUI [8,2])
C0085533 (UMLS CUI [9,1])
C0332197 (UMLS CUI [9,2])
C0392920 (UMLS CUI [10,1])
C1298676 (UMLS CUI [10,2])
C0332197 (UMLS CUI [10,3])
Measurable Disease Radiography | Evaluable Disease Radiography
Item
radiographically measurable or evaluable disease.
boolean
C1513041 (UMLS CUI [1,1])
C0034571 (UMLS CUI [1,2])
C1516986 (UMLS CUI [2,1])
C0034571 (UMLS CUI [2,2])
Life Expectancy
Item
life expectancy of at least 12 weeks.
boolean
C0023671 (UMLS CUI [1])
Neoplasms Without Mutation | Availability of Therapeutic procedure | EGFR Driver Mutation Negative | ALK gene mutation Negative
Item
tumor without activating driver mutations for which there is available therapy (eg, tumor without mutations in epidermal growth factor receptor or anaplastic lymphoma).
boolean
C0027651 (UMLS CUI [1,1])
C0332288 (UMLS CUI [1,2])
C0026882 (UMLS CUI [1,3])
C0470187 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
C4329758 (UMLS CUI [3])
C2825843 (UMLS CUI [4,1])
C1513916 (UMLS CUI [4,2])
Score
Item
an mgps of 1 or 2 as defined below:
boolean
C0449820 (UMLS CUI [1])
Criteria
Item
*criteria:
boolean
C0243161 (UMLS CUI [1])
C-reactive protein measurement | Albumin measurement | Score
Item
c-reactive protein >10 mg/l and albumin ≥35 g/l; score = 1
boolean
C0201657 (UMLS CUI [1])
C0201838 (UMLS CUI [2])
C0449820 (UMLS CUI [3])
C-reactive protein measurement | Albumin measurement | Score
Item
c-reactive protein >10 mg l and albumin <35 g/l; score = 2
boolean
C0201657 (UMLS CUI [1])
C0201838 (UMLS CUI [2])
C0449820 (UMLS CUI [3])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of 0 to 1.
boolean
C1520224 (UMLS CUI [1])
Renal function | Liver function | Bone Marrow function
Item
adequate renal, hepatic, and bone marrow function demonstrated by protocol-specified laboratory parameters at the screening visit.
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C0031843 (UMLS CUI [3,2])
Squamous non-small cell lung cancer | Non-Small Cell Lung Carcinoma Adenosquamous
Item
squamous or mixed histology (eg, adenosquamous) nsclc
boolean
C4509816 (UMLS CUI [1])
C0007131 (UMLS CUI [2,1])
C0279557 (UMLS CUI [2,2])
Systemic therapy Advanced disease | Systemic therapy Neoplasm Metastasis
Item
previous systemic therapy for advanced or metastatic disease.
boolean
C1515119 (UMLS CUI [1,1])
C0679246 (UMLS CUI [1,2])
C1515119 (UMLS CUI [2,1])
C0027627 (UMLS CUI [2,2])
CNS metastases
Item
known active central nervous system (cns) metastases.
boolean
C0686377 (UMLS CUI [1])
Cancer Other | Exception Basal cell carcinoma Cured | Exception Squamous cell carcinoma of skin Cured | Exception Superficial carcinoma of urinary bladder | Exception Prostatic Intraepithelial Neoplasias | Exception Carcinoma in situ of uterine cervix | Exception Malignant Neoplasm indolent
Item
current or previous other malignancy within 2 years of study entry, except cured basal or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial neoplasm, carcinoma in situ of the cervix, or other noninvasive or indolent malignancy without sponsor approval.
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1880198 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1880198 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1336527 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0282612 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0851140 (UMLS CUI [6,2])
C1705847 (UMLS CUI [7,1])
C0006826 (UMLS CUI [7,2])
C0234227 (UMLS CUI [7,3])
Heart Disease Uncontrolled | Angina Pectoris | Myocardial Infarction | Congestive heart failure New York Heart Association Classification | Cardiac Arrhythmia Treatment required for
Item
current uncontrolled cardiac disease such as angina or myocardial infarction, congestive heart failure including new york heart association functional classification of 3, or arrhythmia requiring treatment.
boolean
C0018799 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0002962 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
C0018802 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C0003811 (UMLS CUI [5,1])
C0332121 (UMLS CUI [5,2])
Comorbidity Uncontrolled | Kidney Diseases | Liver diseases | Hematological Disease | Gastrointestinal Diseases | Endocrine System Diseases | Lung diseases | Nervous system disorder | Cerebral disorder | Mental disorders
Item
uncontrolled concomitant medical conditions, including, but not limited to, renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, neurological, cerebral, or psychiatric diseases.
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0022658 (UMLS CUI [2])
C0023895 (UMLS CUI [3])
C0018939 (UMLS CUI [4])
C0017178 (UMLS CUI [5])
C0014130 (UMLS CUI [6])
C0024115 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0234387 (UMLS CUI [9])
C0004936 (UMLS CUI [10])