Non-squamous non-small cell lung cancer TNM clinical staging | Non-squamous non-small cell lung cancer Recurrent TNM clinical staging
Item
histologically or cytologically confirmed diagnosis of nonsquamous nsclc that is stage iiib, stage iv, or recurrent (including stage ii).
boolean
C4324656 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C4324656 (UMLS CUI [2,1])
C2945760 (UMLS CUI [2,2])
C3258246 (UMLS CUI [2,3])
EGFR Activating Mutation Tumor tissue sample | EGFR exon 19 deletion | Point mutation in exon 21 (L858R) | Other Coding
Item
documented evidence of an activating mutation in egfr in tumor samples (exon 19 deletions or point mutation l858r in exon 21 or point mutations at codon 719).
boolean
C2984891 (UMLS CUI [1,1])
C0475358 (UMLS CUI [1,2])
C3889117 (UMLS CUI [2])
C3888903 (UMLS CUI [3])
C3846158 (UMLS CUI [4])
Other Coding
Item
a mgps of 1 or 2 as defined below:
boolean
C3846158 (UMLS CUI [1])
C-reactive protein measurement | Albumin measurement | Score
Item
criteria: c-reactive protein >10 mg/l and albumin ≥35 g/l score-1
boolean
C0201657 (UMLS CUI [1])
C0201838 (UMLS CUI [2])
C0449820 (UMLS CUI [3])
C-reactive protein measurement | Albumin measurement | Score
Item
criteria: c-reactive protein >10 mg l and albumin <35 g/l score-2
boolean
C0201657 (UMLS CUI [1])
C0201838 (UMLS CUI [2])
C0449820 (UMLS CUI [3])
Measurable Disease Radiography | Evaluable Disease Radiography
Item
radiographically measurable or evaluable disease.
boolean
C1513041 (UMLS CUI [1,1])
C0034571 (UMLS CUI [1,2])
C1516986 (UMLS CUI [2,1])
C0034571 (UMLS CUI [2,2])
Life Expectancy
Item
life expectancy of at least 12 weeks.
boolean
C0023671 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of 0 to 2.
boolean
C1520224 (UMLS CUI [1])
Renal function | Liver function | Bone Marrow function
Item
adequate renal, hepatic, and bone marrow function demonstrated by protocol-specified laboratory parameters at the screening visit.
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C0031843 (UMLS CUI [3,2])
EGFR T790M Mutation Tumor tissue sample
Item
known presence of the t790m mutation in egfr in tumor samples
boolean
C3274192 (UMLS CUI [1,1])
C0026882 (UMLS CUI [1,2])
C0475358 (UMLS CUI [1,3])
Therapeutic radiology procedure Curative | Curative Surgery
Item
candidates for curative radiation therapy or surgery.
boolean
C1522449 (UMLS CUI [1,1])
C1276305 (UMLS CUI [1,2])
C1511562 (UMLS CUI [2])
Systemic Chemotherapy Advanced disease | EGFR inhibitor
Item
previous systemic chemotherapy for advanced disease, including egfr inhibitor therapy, except subjects who received 1 cycle of chemotherapy while waiting to receive egfr results, who may enroll provided that 21 days have elapsed from end of chemotherapy to the day to the baseline radiographic measurement prior to cycle 1 day 1.
boolean
C1883256 (UMLS CUI [1,1])
C0679246 (UMLS CUI [1,2])
C1443775 (UMLS CUI [2])
Pulmonary Fibrosis | Lung Disease, Interstitial | Pulmonary Fibrosis Suspected | Interstitial Lung Disease Suspected
Item
distinct or suspected, or history of, pulmonary fibrosis or ild.
boolean
C0034069 (UMLS CUI [1])
C0206062 (UMLS CUI [2])
C0034069 (UMLS CUI [3,1])
C0750491 (UMLS CUI [3,2])
C0206062 (UMLS CUI [4,1])
C0750491 (UMLS CUI [4,2])
Cancer Other | Exception Basal cell carcinoma Cured | Exception Squamous cell carcinoma of skin Cured | Exception Superficial carcinoma of urinary bladder | Exception Prostatic Intraepithelial Neoplasias | Exception Carcinoma in situ of uterine cervix | Exception Malignant Neoplasm TNM clinical staging
Item
current or previous other malignancy within 2 years of study entry, except cured basal or squamous cell skin cancer, superficial bladder cancer, prostate intraepithelial neoplasm, carcinoma in situ of the cervix, or other noninvasive indolent or stage i malignancy without sponsor approval.
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1880198 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0553723 (UMLS CUI [3,2])
C1880198 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1336527 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0282612 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0851140 (UMLS CUI [6,2])
C1705847 (UMLS CUI [7,1])
C0006826 (UMLS CUI [7,2])
C3258246 (UMLS CUI [7,3])