Breast Carcinoma
Item
histologically or cytologically confirmed carcinoma of the breast
boolean
C0678222 (UMLS CUI [1])
Advanced disease Locally | Neoplasm Metastasis
Item
locally advanced and/or metastatic disease
boolean
C0679246 (UMLS CUI [1,1])
C1517927 (UMLS CUI [1,2])
C0027627 (UMLS CUI [2])
Deleterious BRCA1 Gene Mutation | BRCA1 gene mutation Pathogenic | Deleterious BRCA2 Gene Mutation | BRCA2 gene mutation Pathogenic
Item
deleterious or pathogenic germline brca 1 or brca 2 mutation
boolean
C4289700 (UMLS CUI [1])
C1511022 (UMLS CUI [2,1])
C3816499 (UMLS CUI [2,2])
C4287905 (UMLS CUI [3])
C1511024 (UMLS CUI [4,1])
C3816499 (UMLS CUI [4,2])
Prior Chemotherapy | Partial response Platinum Neoplasm Metastasis | In complete remission Platinum Neoplasm Metastasis | Disease Progression | Chemotherapy Regimen Quantity Neoplasm Metastasis | Platinum Absent Neoplasm Metastasis
Item
prior chemotherapy: cohort 1) pr or cr to prior platinum-containing regimen for metastatic disease with disease progression > 8 weeks following the last dose of platinum; or cohort 2) > 2 prior chemotherapy regimens for metastatic disease and no prior platinum for metastatic disease
boolean
C1514457 (UMLS CUI [1])
C1521726 (UMLS CUI [2,1])
C0032207 (UMLS CUI [2,2])
C0027627 (UMLS CUI [2,3])
C0677874 (UMLS CUI [3,1])
C0032207 (UMLS CUI [3,2])
C0027627 (UMLS CUI [3,3])
C0242656 (UMLS CUI [4])
C0392920 (UMLS CUI [5,1])
C1265611 (UMLS CUI [5,2])
C0027627 (UMLS CUI [5,3])
C0032207 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0027627 (UMLS CUI [6,3])
ECOG performance status
Item
ecog performance status ≤ 1
boolean
C1520224 (UMLS CUI [1])
Organ function
Item
have adequate organ function
boolean
C0678852 (UMLS CUI [1])
Study Subject Participation Status | PARP Inhibitors
Item
prior enrollment into a clinical trial of a parp inhibitor
boolean
C2348568 (UMLS CUI [1])
C1882413 (UMLS CUI [2])
CNS metastases CT | CNS metastases MRI scan | Exception Metastatic malignant neoplasm to brain Treated | Disease Progression Absent | Adrenal Cortex Hormones Absent
Item
cns metastasis except adequately treated brain metastasis documented by baseline ct or mri scan that has not progressed since previous scans and that does not require corticosteroids for management of cns symptoms
boolean
C0686377 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C0686377 (UMLS CUI [2,1])
C0024485 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0220650 (UMLS CUI [3,2])
C1522326 (UMLS CUI [3,3])
C0242656 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0001617 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
Malignant Neoplasms Previous | Exception Malignant Neoplasm Associated with BRCA gene | Exception Disease Free | Exception Carcinoma in situ of uterine cervix | Exception Skin carcinoma | Exception Malignant Neoplasm Treated | Exception Recurrence Absent
Item
prior malignancy except for prior brca-associated cancer as long as there is no current evidence of the prior cancer, carcinoma in situ of the cervix or non-melanoma skin cancer, and a cancer diagnosed and definitively treated >5 years prior to study enrollment with no subsequent evidence of recurrence
boolean
C0006826 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0006826 (UMLS CUI [2,2])
C0332281 (UMLS CUI [2,3])
C0596223 (UMLS CUI [2,4])
C1705847 (UMLS CUI [3,1])
C0012634 (UMLS CUI [3,2])
C0332296 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0851140 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0699893 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0006826 (UMLS CUI [6,2])
C1522326 (UMLS CUI [6,3])
C1705847 (UMLS CUI [7,1])
C0034897 (UMLS CUI [7,2])
C0332197 (UMLS CUI [7,3])
HIV Seropositivity | Hepatitis C virus | Hepatitis B Virus
Item
known to be hiv positive, active hepatitis c virus, or active hepatitis b virus
boolean
C0019699 (UMLS CUI [1])
C0220847 (UMLS CUI [2])
C0019169 (UMLS CUI [3])
Hypersensitivity Talazoparib Component
Item
known hypersensitivity to any of the components of talazoparib
boolean
C0020517 (UMLS CUI [1,1])
C4042960 (UMLS CUI [1,2])
C1705248 (UMLS CUI [1,3])