Deleterious Germline Mutation BRCA1 predicted | Deleterious Germline Mutation BRCA2 predicted | Deleterious Germline Mutation BRCA1 Suspected | Deleterious Germline Mutation BRCA2 Suspected
Item
germline mutation in brca1 or brca2 that is predicted to be deleterious or suspected deleterious.
boolean
C4329707 (UMLS CUI [1,1])
C0376571 (UMLS CUI [1,2])
C0681842 (UMLS CUI [1,3])
C4329707 (UMLS CUI [2,1])
C0598034 (UMLS CUI [2,2])
C0681842 (UMLS CUI [2,3])
C4329707 (UMLS CUI [3,1])
C0376571 (UMLS CUI [3,2])
C0750491 (UMLS CUI [3,3])
C4329707 (UMLS CUI [4,1])
C0598034 (UMLS CUI [4,2])
C0750491 (UMLS CUI [4,3])
Secondary malignant neoplasm of female breast
Item
histologically or cytologically confirmed breast cancer with evidence of metastatic disease.
boolean
C0346993 (UMLS CUI [1])
Anthracycline Adjuvant therapy | Anthracycline Metastatic Setting | Taxane Adjuvant therapy | Taxane Metastatic Setting
Item
prior therapy with an anthracycline and a taxane in either an adjuvant or metastatic setting.
boolean
C0282564 (UMLS CUI [1,1])
C0677850 (UMLS CUI [1,2])
C0282564 (UMLS CUI [2,1])
C4085632 (UMLS CUI [2,2])
C0215136 (UMLS CUI [3,1])
C0677850 (UMLS CUI [3,2])
C0215136 (UMLS CUI [4,1])
C4085632 (UMLS CUI [4,2])
Platinum | Breast Carcinoma Progression Absent | Platinum Adjuvant therapy | Platinum Neoadjuvant Therapy
Item
prior platinum allowed as long as no breast cancer progression occurred on treatment or if given in adjuvant/neoadjuvant setting at least 12 months from last dose to study entry elapsed.
boolean
C0032207 (UMLS CUI [1])
C0678222 (UMLS CUI [2,1])
C0449258 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0032207 (UMLS CUI [3,1])
C0677850 (UMLS CUI [3,2])
C0032207 (UMLS CUI [4,1])
C0600558 (UMLS CUI [4,2])
Breast Carcinoma Estrogen receptor positive | Breast Carcinoma Progesterone receptor positive | Hormone Therapy Adjuvant Quantity | Hormone Therapy Quantity Metastatic Setting | Disease Progression | Disease Inappropriate Hormone Therapy
Item
er/pr breast cancer positive patients must have received and progressed on at least one endocrine therapy (adjuvant or metastatic), or have disease that the treating physician believes to be inappropriate for endocrine therapy.
boolean
C0678222 (UMLS CUI [1,1])
C0279754 (UMLS CUI [1,2])
C0678222 (UMLS CUI [2,1])
C0279759 (UMLS CUI [2,2])
C0279025 (UMLS CUI [3,1])
C1522673 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
C0279025 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
C4085632 (UMLS CUI [4,3])
C0242656 (UMLS CUI [5])
C0012634 (UMLS CUI [6,1])
C1548788 (UMLS CUI [6,2])
C0279025 (UMLS CUI [6,3])
ECOG performance status
Item
ecog performance status 0-1.
boolean
C1520224 (UMLS CUI [1])
Bone Marrow function | Renal function | Liver function
Item
adequate bone marrow, kidney and liver function.
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
Poly(ADP-ribose) Polymerase Inhibitors
Item
prior treatment with parp inhibitor.
boolean
C1882413 (UMLS CUI [1])
Disease HER2 Positive
Item
patients with her2 positive disease.
boolean
C0012634 (UMLS CUI [1,1])
C2348909 (UMLS CUI [1,2])
Prior Chemotherapy Quantity Secondary malignant neoplasm of female breast
Item
more than 2 prior lines of chemotherapy for metastatic breast cancer.
boolean
C1514457 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0346993 (UMLS CUI [1,3])
Metastatic malignant neoplasm to brain Untreated | Metastatic malignant neoplasm to brain Uncontrolled
Item
untreated and/or uncontrolled brain metastases.
boolean
C0220650 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
C0220650 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Malignant Neoplasms | Exception Curative treatment | Exception Disease Free Duration | Exception Skin carcinoma Treated | Exception Carcinoma in situ of uterine cervix Treated | Exception DCIS Treated | Exception Endometrial cancer stage Grade Treated
Item
prior malignancy unless curatively treated and disease-free for > 5 years prior to study entry. prior adequately treated non-melanoma skin cancer, in situ cancer of the cervix, dcis or stage i grade 1 endometrial cancer allowed.
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1273390 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0012634 (UMLS CUI [3,2])
C0332296 (UMLS CUI [3,3])
C0449238 (UMLS CUI [3,4])
C1705847 (UMLS CUI [4,1])
C0699893 (UMLS CUI [4,2])
C1522326 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C0851140 (UMLS CUI [5,2])
C1522326 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0007124 (UMLS CUI [6,2])
C1522326 (UMLS CUI [6,3])
C1705847 (UMLS CUI [7,1])
C0280255 (UMLS CUI [7,2])
C0441800 (UMLS CUI [7,3])
C1522326 (UMLS CUI [7,4])
HIV Infection
Item
known hiv (human immunodeficiency virus) infection.
boolean
C0019693 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or breast-feeding women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])